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View Structure Prediction Details

Protein: TYSY_CHRVO
Organism: Chromobacterium violaceum ATCC 12472
Length: 264 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYSY_CHRVO.

Description E-value Query
Range
Subject
Range
gi|11256672 - pir||A81825 thymidylate synthase (EC 2.1.1.45) NMA1963 [imported] - Neisseria meningitidis (strain Z...
TYSY_NEIMA - Thymidylate synthase OS=Neisseria meningitidis serogroup A GN=thyA PE=3 SV=1
TYSY_NEIMA - Thymidylate synthase OS=Neisseria meningitidis serogroup A / serotype 4A (strain Z2491) GN=thyA PE=3...
472.0 [0..1] [264..1]

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Predicted Domain #1
Region A:
Residues: [1-264]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQYLDLMRH VLEHGHDKAD RTGTGTRSVF GYQMRFDLAA GFPLVTTKKC HLRSIIHELL  60
   61 WFLSGDTNIR YLKENGVSIW DEWADENGDL GPVYGYQWRS WPAPDGRHID QISQLLDMIK 120
  121 KNPDSRRLIV SAWNPALVDQ MALPPCHSLF QFYVANGRLS CQLYQRSADI FLGVPFNIAS 180
  181 YALLTMMVAQ VCGLQPGDFV HTLGDAHLYS NHLEQARLQL TRDPRPLPTM KLNPEVKDLF 240
  241 AFTFDDFALE GYDPHPHIKA QVAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 131.0
Match: 1f4bA
Description: Thymidylate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
thymidylate synthase activity 6.6988475347328 bayes_pls_golite062009
5,10-methylenetetrahydrofolate-dependent methyltransferase activity 6.29181090719132 bayes_pls_golite062009
binding 1.89072001556053 bayes_pls_golite062009
catalytic activity 1.73427871128495 bayes_pls_golite062009
transferase activity 1.72626940963556 bayes_pls_golite062009
methyltransferase activity 0.927096828883487 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.91282507161672 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle