YRC Public Data Repository - Protein Structure Prediction

Protein:	SYI_YERPS
Organism:	Yersinia pseudotuberculosis IP 32953
Length:	938 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYI_YERPS.

Description	E-value	Query Range	Subject Range
SYI_SHIBS - Isoleucine--tRNA ligase OS=Shigella boydii serotype 4 (strain Sb227) GN=ileS PE=3 SV=1	0.0	[1..938]	[1..938]
SYI_SHIFL - Isoleucine--tRNA ligase OS=Shigella flexneri GN=ileS PE=3 SV=1 gi\|24050221, gi\|... - gi\|24111471\|ref\|NP_705981.1\| isoleucyl-tRNA synthetase [Shigella flexneri 2a str. 301], gi\|24050221\|...	0.0	[1..938]	[1..938]
SYI_ESCF3 - Isoleucine--tRNA ligase OS=Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) GN=i... SYI_ECO24 - Isoleucine--tRNA ligase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=ileS PE=3 SV=1	0.0	[1..938]	[1..938]
SYI_ECOL5 - Isoleucine--tRNA ligase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=ileS PE=3 SV=1 gi\|191174124, gi... - gi\|75237181\|ref\|ZP_00721229.1\| COG0060: Isoleucyl-tRNA synthetase [Escherichia coli F11], gi\|1911741...	0.0	[1..938]	[1..938]
SYI_ECO55 - Isoleucine--tRNA ligase OS=Escherichia coli (strain 55989 / EAEC) GN=ileS PE=3 SV=1 gi\|89106910, gi\|... - gi\|89106910\|ref\|AP_000690.1\| isoleucyl-tRNA synthetase [Escherichia coli str. K-12 substr. W3110], g... SYI_ECODH - Isoleucine--tRNA ligase OS=Escherichia coli (strain K12 / DH10B) GN=ileS PE=3 SV=1 SYI_ECOSE - Isoleucine--tRNA ligase OS=Escherichia coli (strain SE11) GN=ileS PE=3 SV=1 SYI_ECO8A - Isoleucine--tRNA ligase OS=Escherichia coli O8 (strain IAI1) GN=ileS PE=3 SV=1 gi\|193070965, gi... - gi\|75234163\|ref\|ZP_00718567.1\| COG0060: Isoleucyl-tRNA synthetase [Escherichia coli E110019], gi\|193... gi\|193066215, gi... - gi\|75255681\|ref\|ZP_00727447.1\| COG0060: Isoleucyl-tRNA synthetase [Escherichia coli E22], gi\|1930662... gi\|190901059, gi... - gi\|75227856\|ref\|ZP_00714566.1\| COG0060: Isoleucyl-tRNA synthetase [Escherichia coli B7A], gi\|1911688... EG10492 - isoleucyl-tRNA synthetase / Isoleucine--tRNA ligase SYI_ECOLI - Isoleucyl-tRNA synthetase (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) - Escherichia coli EG10492 - isoleucyl-tRNA synthetase / Isoleucine--tRNA ligase SYI_ECOBW - Isoleucine--tRNA ligase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=ileS PE=3 SV=1 SYI_SHISS - Isoleucine--tRNA ligase OS=Shigella sonnei (strain Ss046) GN=ileS PE=3 SV=1	0.0	[1..938]	[1..938]
gi\|194439692, gi... - gi\|83584930\|ref\|ZP_00923587.1\| COG0060: Isoleucyl-tRNA synthetase [Escherichia coli 101-1], gi\|19443... gi\|188492266, gi... - gi\|75515614\|ref\|ZP_00737771.1\| COG0060: Isoleucyl-tRNA synthetase [Escherichia coli 53638], gi\|18849...	0.0	[1..938]	[1..938]
SYI_SHIB3 - Isoleucine--tRNA ligase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=ileS PE=3 SV=...	0.0	[1..938]	[1..938]
gi\|227837909, gi... - gi\|227885080\|ref\|ZP_04002885.1\| isoleucyl-tRNA synthetase [Escherichia coli 83972], gi\|227837909\|gb\|... SYI_ECOL6 - Isoleucine--tRNA ligase OS=Escherichia coli O6 GN=ileS PE=3 SV=1 SYI_ECOL6 - Isoleucine--tRNA ligase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=ileS PE=3 ... SYI_ECO81 - Isoleucine--tRNA ligase OS=Escherichia coli O81 (strain ED1a) GN=ileS PE=3 SV=1	0.0	[1..938]	[1..938]
gi\|30061594, gi\|... - gi\|30061594\|ref\|NP_835765.1\| isoleucyl-tRNA synthetase [Shigella flexneri 2a str. 2457T], gi\|3003983...	0.0	[1..938]	[1..938]
SYI_SHIDS - Isoleucine--tRNA ligase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=ileS PE=3 SV=1	0.0	[1..938]	[1..938]

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Predicted Domain #1

Region A:
Residues: [1-938]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDYKNTLNL PETGFPMRGD LAKREPDMLK RWYEQDLYGI IRAAKKGKKT FILHDGPPYA  60
   61 NGNIHIGHSV NKILKDIIVK SKGMAGYDSP YIPGWDCHGL PIELKVEQLI GKPGEKVSAA 120
  121 EFRTACRKYA AEQVEGQKKD FIRLGVLGDW DHPYLTMDFK TEANIIRALS KIIDNGHLHK 180
  181 GAKPVHWCTD CGSSLAEAEV EYYDKTSQSI DVRFNAVDTA TVAAKFGVSA VNGPISLVIW 240
  241 TTTPWTLPAN RAISLNAEYL YQLVQVEGEC LILAADLVES VMKRAGITQW AVLGSCTGSD 300
  301 LELLRFTHPF MGFDVPAILG DHVTLDAGTG AVHTAPGHGP DDFVIGQKYG LEVANPVGPN 360
  361 GCYLAGTYPT LDGLFVFKAN DVVVELLREK GALLHVEKLL HSYPCCWRHK TPIIFRATPQ 420
  421 WFISMDQKGL RKQSLQEIKG VQWIPDWGQA RIETMVANRP DWCISRQRTW GVPMSLFVHK 480
  481 ETEQLHPRSI ELMEEVAKRV EQDGIQAWWD LDPAEILGAD AADYVKVPDT LDVWFDSGST 540
  541 HSSVVDVRPE FGGHSPDMYL EGSDQHRGWF MSSLMIATAM KGKAPYRQVL THGFTVDGQG 600
  601 RKMSKSIGNT ISPQDVMNKL GGDILRLWVA STDYTGEIAV SDEILKRSAD SYRRIRNTAR 660
  661 FLLANLNGFD PAQHQVKPEE MVVVDRWAVG RAQAAQAEIM EAYENYDFHL VVQRLMQFCS 720
  721 VEMGSFYLDI IKDRQYTAKG DGIARRSCQT ALFHIAEALV RWMAPIMSFT ADEIWNHLPG 780
  781 ERQQYVFTEE WYDGLFGLAG NESMNDTFWA ELLKVRGEVN KVLEQARSDK RIGGSLEAAV 840
  841 TLYAEPELAA RLNSLQDELR FVLLTSAAKV AAYADAGNDA QQSELIAGLK ITFNKADGEK 900
  901 CPRCWHYTQD VGLVAEHAEL CGRCVTNVAG DGEERKFA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1ffyA
Description:	Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	7.16276509815667	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.16276509815667	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.13957775963187	bayes_pls_golite062009
valine-tRNA ligase activity	7.13767629265822	bayes_pls_golite062009
isoleucine-tRNA ligase activity	6.38633897147986	bayes_pls_golite062009
ligase activity	6.11211476973434	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.63681738794687	bayes_pls_golite062009
leucine-tRNA ligase activity	2.62601062778624	bayes_pls_golite062009
methionine-tRNA ligase activity	2.56893064485672	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.88984817882585	bayes_pls_golite062009
arginine-tRNA ligase activity	1.50161401062914	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.14187887833901	bayes_pls_golite062009
cysteine-tRNA ligase activity	0.844943947059557	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.625793556381714	bayes_pls_golite062009
binding	0.485102284225571	bayes_pls_golite062009
nucleic acid binding	0.449504767632354	bayes_pls_golite062009
nucleotidyltransferase activity	0.2293846471193	bayes_pls_golite062009
glutamine-tRNA ligase activity	0.118292082006187	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: