YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|23497027, gi\|...
Organism:	Plasmodium falciparum 3D7
Length:	210 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|23497027, gi|....

Description	E-value	Query Range	Subject Range
gi\|56494802 - gi\|56494802\|emb\|CAH95718.1\| thymidylate kinase, putative [Plasmodium berghei] gi\|68067163 - gi\|68067163\|ref\|XP_675552.1\| thymidylate kinase [Plasmodium berghei strain ANKA]	172.0	[0..3]	[210..10]
gi\|62424658 - gi\|62424658\|ref\|ZP_00379801.1\| COG0477: Permeases of the major facilitator superfamily [Brevibacteri...	158.0	[0..8]	[202..426]
gi\|118351574 - gi\|118351574\|ref\|XP_001009062.1\| thymidylate kinase family protein [Tetrahymena thermophila] gi\|118351574, gi... - gi\|89290829\|gb\|EAR88817.1\| thymidylate kinase family protein [Tetrahymena thermophila SB210], gi\|118...	157.0	[0..4]	[209..1]
gi\|89266991, gi\|... - gi\|89266991\|emb\|CAJ81735.1\| deoxythymidylate kinase (thymidylate kinase) [Xenopus tropicalis], gi\|55... gi\|55742029 - ref\|NP_001006834.1\| deoxythymidylate kinase (thymidylate kinase) [Xenopus tropicalis]	155.0	[0..7]	[209..5]
gi\|16975316 - gi\|16975316\|pdb\|1E9F\|A Chain A, Mutant Human Thymidylate Kinase Complexed With Tmp And Adp	154.0	[0..6]	[209..7]
gi\|86608314 - gi\|86608314\|ref\|YP_477076.1\| thymidylate kinase [Cyanobacteria bacterium Yellowstone B-Prime] KTHY_SYNJB - Thymidylate kinase OS=Synechococcus sp. (strain JA-2-3B'a(2-13)) GN=tmk PE=3 SV=1	153.0	[0..10]	[200..2]
KTHY_DICDI - Thymidylate kinase OS=Dictyostelium discoideum GN=dtymk PE=3 SV=1 gi\|66804303, gi\|... - gi\|66804303\|ref\|XP_635930.1\| thymidylate kinase [Dictyostelium discoideum AX4], gi\|60464271\|gb\|EAL62...	153.0	[0..3]	[203..14]
gi\|84326490 - gi\|84326490\|ref\|ZP_00974517.1\| COG0125: Thymidylate kinase [Pseudomonas aeruginosa 2192]	153.0	[0..6]	[208..1]
gi\|78070418, gi\|... - gi\|80751137\|ref\|NP_001032187.1\| deoxythymidylate kinase [Danio rerio], gi\|78070418\|gb\|AAI07816.1\| Zg...	153.0	[0..6]	[209..4]
KTHY_CARHZ - Thymidylate kinase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) GN...	152.0	[0..6]	[196..1]

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Predicted Domain #1

Region A:
Residues: [1-210]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDDKKKGKF IVFEGLDRSG KSTQSKLLVE YLKNNNVEVK HLYFPNRETG IGQIISKYLK  60
   61 MENSMSNETI HLLFSANRWE HMNEIKSLLL KGIWVVCDRY AYSGVAYSSG ALNLNKTWCM 120
  121 NPDQGLIKPD VVFYLNVPPN YAQNRSDYGE EIYEKVETQK KIYETYKHFA HEDYWINIDA 180
  181 TRKIEDIHND IVKEVTKIKV EPEEFNFLWS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.0
Match:	1e9fA
Description:	Thymidylate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	3.66392587433723	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.01286198424677	bayes_pls_golite062009
nucleotide kinase activity	2.24094813695083	bayes_pls_golite062009
kinase activity	2.0779386406753	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.06460241490722	bayes_pls_golite062009
binding	2.05253348982328	bayes_pls_golite062009
substrate-specific transporter activity	2.0114051513686	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	1.96697952975573	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.92626167278464	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.9136419736217	bayes_pls_golite062009
ion transmembrane transporter activity	1.6854386921174	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.64467072658718	bayes_pls_golite062009
cation transmembrane transporter activity	1.5008821138859	bayes_pls_golite062009
nucleic acid binding	1.49633029954726	bayes_pls_golite062009
pyrophosphatase activity	1.49611313354225	bayes_pls_golite062009
DNA-dependent ATPase activity	1.2155186842031	bayes_pls_golite062009
helicase activity	1.16085745407703	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA binding	0.967303417236485	bayes_pls_golite062009
transcription regulator activity	0.748437190903548	bayes_pls_golite062009
DNA helicase activity	0.72881469450553	bayes_pls_golite062009
structure-specific DNA binding	0.720649395550746	bayes_pls_golite062009
ATP-dependent helicase activity	0.59513742813869	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.59513742813869	bayes_pls_golite062009
double-stranded DNA binding	0.58862275163252	bayes_pls_golite062009
adenylate kinase activity	0.447752711852745	bayes_pls_golite062009
CTP synthase activity	0.435702031552231	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.3625050107782	bayes_pls_golite062009
DNA clamp loader activity	0.27925703205288	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.22150712609541	bayes_pls_golite062009
protein binding	0.193768631623192	bayes_pls_golite062009
nucleotide binding	0.114848452385726	bayes_pls_golite062009
purine nucleotide binding	0.10713474095071	bayes_pls_golite062009
purine ribonucleotide binding	0.0916519414118148	bayes_pls_golite062009
ribonucleotide binding	0.0915913646217636	bayes_pls_golite062009
DNA polymerase activity	4.95561462330096E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: