YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7494451, gi\|9...
Organism:	Plasmodium falciparum
Length:	240 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7494451, gi|9....

Description	E-value	Query Range	Subject Range
ISPF_HAEIE - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Haemophilus influenzae (strain PittEE) GN=i... ISPF_HAEIN - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Haemophilus influenzae GN=ispF PE=1 SV=1 ISPF_HAEIN - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Haemophilus influenzae (strain ATCC 51907 /... gi\|229847228, gi... - gi\|229847228\|ref\|ZP_04467332.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Haemophilus i...	258.0	[0..64]	[238..2]
ISPF_PECAS - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Pectobacterium atrosepticum (strain SCRI 10... ISPF_ERWCT - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Erwinia carotovora subsp. atroseptica GN=is... gi\|227327755 - gi\|227327755\|ref\|ZP_03831779.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Pectobacteriu...	258.0	[0..64]	[240..1]
gi\|145629642, gi... - gi\|145629642\|ref\|ZP_01785439.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Haemophilus i... gi\|46133032 - gi\|46133032\|ref\|ZP_00156473.2\| COG0245: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Haemop...	257.0	[0..64]	[238..2]
gi\|42628891 - gi\|42628891\|ref\|ZP_00154443.1\| COG0245: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Haemop...	256.0	[0..64]	[238..2]
ISPF_ACTP2 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Actinobacillus pleuropneumoniae serotype 5b... gi\|46143508 - gi\|46143508\|ref\|ZP_00204492.1\| COG0245: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Actino... ISPF_ACTPJ - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Actinobacillus pleuropneumoniae serotype 3 ...	256.0	[0..64]	[238..2]
gi\|67156386, gi\|... - gi\|67156386\|ref\|ZP_00417979.1\| MECDP-synthase [Azotobacter vinelandii AvOP], ref\|ZP_00091526.1\| COG0... ISPF_AZOVD - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Azotobacter vinelandii (strain DJ / ATCC BA...	253.0	[0..64]	[235..1]
ISPF_HAEI8 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Haemophilus influenzae (strain 86-028NP) GN...	252.0	[0..64]	[238..2]
ISPF_GEOKA - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Geobacillus kaustophilus GN=ispF PE=3 SV=1 ISPF_GEOKA - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Geobacillus kaustophilus (strain HTA426) GN...	252.0	[0..65]	[237..3]
ISPF_BACC1 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cereus (strain ATCC 10987 / NRS 24...	252.0	[0..65]	[238..3]
ISPDF_NOVAD - Bifunctional enzyme IspD/IspF OS=Novosphingobium aromaticivorans (strain DSM 12444 / F199) GN=ispDF ...	252.0	[0..41]	[236..211]

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Predicted Domain #1

Region A:
Residues: [1-240]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLKGYTSNV VLIILTFFIL LTKEEKNIKN NISGYCFLNF GLKKNAIIKK REKQNLKLFC  60
   61 YNGIRIGQGY DIHKIKVLDE EYNTYANNDF NKNEQSFKTL TLGGVKINNV LVLSHSDGDI 120
  121 IYHSIVDSIL GALGSLDIGT LFPDKDEKNK NKNSAIFLRY ARLLIYKKNY DIGNVDINVI 180
  181 AQVPKISNIR KNIIKNISTV LNIDESQISV KGKTHEKLGV IGEKKAIECF ANILLIPKNS 240
  241

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.221849
Match:	1vh8A
Description:	Crystal structure of a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity	5.90222038729348	bayes_pls_golite062009
phosphorus-oxygen lyase activity	3.82238498158628	bayes_pls_golite062009
catalytic activity	1.89592759292365	bayes_pls_golite062009
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	1.55973202658962	bayes_pls_golite062009
lyase activity	1.47817320758946	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: