YRC Public Data Repository - Protein Structure Prediction

Protein:	EG12197
Organism:	Escherichia coli K-12
Length:	181 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG12197.

Description	E-value	Query Range	Subject Range
gi\|26246664, gi\|... - gi\|26246664\|ref\|NP_752704.1\| SeqA protein [Escherichia coli CFT073], gi\|26107063\|gb\|AAN79247.1\|AE016...	324.0	[0..1]	[181..46]
gi\|91209730, gi\|... - gi\|91209730\|ref\|YP_539716.1\| negative modulator of initiation of replication [Escherichia coli UTI89...	323.0	[0..1]	[181..46]
gi\|75511143 - gi\|75511143\|ref\|ZP_00733861.1\| COG3057: Negative regulator of replication initiationR [Escherichia c...	320.0	[0..1]	[181..24]
gi\|110614224, gi... - gi\|110804676\|ref\|YP_688196.1\| replication initiation regulator SeqA [Shigella flexneri 5 str. 8401],...	315.0	[0..1]	[181..12]
gi\|75177438 - gi\|75177438\|ref\|ZP_00697519.1\| COG3057: Negative regulator of replication initiationR [Shigella boyd...	315.0	[0..1]	[181..2]
gi\|15829972, gi\|... - gi\|15829972\|ref\|NP_308745.1\| replication initiation regulator SeqA [Escherichia coli O157:H7 str. Sa... gi\|15829972, gi\|... - gi\|15829972\|ref\|NP_308745.1\| negative modulator of initiation of replication [Escherichia coli O157:... gi\|208822812, gi... - gi\|208822812\|ref\|ZP_03263130.1\| protein SeqA [Escherichia coli O157:H7 str. EC4042], gi\|208737005\|gb... gi\|209776718, gi... - pir\|\|F85568 negative modulator of initiation of replication [imported] - Escherichia coli (strain O1... gi\|209157869, gi... - gi\|209396469\|ref\|YP_002269315.1\| protein SeqA [Escherichia coli O157:H7 str. EC4115], gi\|209157869\|g... gi\|217321461, gi... - gi\|217325240\|ref\|ZP_03441324.1\| protein SeqA [Escherichia coli O157:H7 str. TW14588], gi\|217321461\|g... gi\|15800390, gi\|... - gi\|15800390\|ref\|NP_286402.1\| replication initiation regulator SeqA [Escherichia coli O157:H7 EDL933]... gi\|168786841, gi... - gi\|189373082\|gb\|EDU91498.1\| protein SeqA [Escherichia coli O157:H7 str. EC869], gi\|168786841\|ref\|ZP_... gi\|195939033 - gi\|195939033\|ref\|ZP_03084415.1\| replication initiation regulator SeqA [Escherichia coli O157:H7 str.... gi\|208729378, gi... - gi\|208809577\|ref\|ZP_03251914.1\| protein SeqA [Escherichia coli O157:H7 str. EC4206], gi\|208729378\|gb... gi\|254591239, gi... - gi\|254791839\|ref\|YP_003076676.1\| regulatory protein for replication initiation [Escherichia coli O15... gi\|208815671, gi... - gi\|208815671\|ref\|ZP_03256850.1\| protein SeqA [Escherichia coli O157:H7 str. EC4045], gi\|208732319\|gb... gi\|168757140, gi... - gi\|189355796\|gb\|EDU74215.1\| protein SeqA [Escherichia coli O157:H7 str. EC4401], gi\|168757140\|ref\|ZP... gi\|189363366, gi... - gi\|189363366\|gb\|EDU81785.1\| protein SeqA [Escherichia coli O157:H7 str. EC4486], gi\|168767128\|ref\|ZP... gi\|189003069, gi... - gi\|189003069\|gb\|EDU72055.1\| protein SeqA [Escherichia coli O157:H7 str. EC4076], gi\|168779172\|ref\|ZP...	315.0	[0..1]	[181..1]
gi\|81244532, gi\|... - gi\|82543121\|ref\|YP_407068.1\| replication initiation regulator SeqA [Shigella boydii Sb227], gi\|81244...	315.0	[0..1]	[181..1]
gi\|117622895, gi... - gi\|117622895\|ref\|YP_851808.1\| replication initiation regulator SeqA [Escherichia coli APEC O1], gi\|1... gi\|162138472 - gi\|162138472\|ref\|YP_539716.2\| replication initiation regulator SeqA [Escherichia coli UTI89] gi\|218557616, gi... - gi\|218557616\|ref\|YP_002390529.1\| replication initiation regulator SeqA [Escherichia coli S88], gi\|21... gi\|237707343, gi... - gi\|237707343\|ref\|ZP_04537824.1\| SeqA protein [Escherichia sp. 3_2_53FAA], gi\|226898553\|gb\|EEH84812.1...	315.0	[0..1]	[181..1]
gi\|75209740 - gi\|75209740\|ref\|ZP_00709948.1\| COG3057: Negative regulator of replication initiationR [Escherichia c...	312.0	[0..1]	[181..11]
SEQA_SHIDS - Negative modulator of initiation of replication OS=Shigella dysenteriae serotype 1 (strain Sd197) GN...	311.0	[0..1]	[181..1]

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Predicted Domain #1

Region A:
Residues: [1-181]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTIEVDDEL YSYIASHTKH IGESASDILR RMLKFSAASQ PAAPVTKEVR VASPAIVEAK  60
   61 PVKTIKDKVR AMRELLLSDE YAEQKRAVNR FMLLLSTLYS LDAQAFAEAT ESLHGRTRVY 120
  121 FAADEQTLLK NGNQTKPKHV PGTPYWVITN TNTGRKCSMI EHIMQSMQFP AELIEKVCGT 180
  181 I

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	61.154902
Match:	1lrrA
Description:	Replication modulator SeqA, C-terminal DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA binding	1.66675027391619	bayes_pls_golite062009
nucleic acid binding	1.53696912152919	bayes_pls_golite062009
binding	1.4518686482116	bayes_pls_golite062009
DNA replication origin binding	1.34568721590475	bayes_pls_golite062009
sequence-specific DNA binding	0.14998082978656	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: