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View Structure Prediction Details

Protein: CNN2_PONPY
Organism: Pongo pygmaeus
Length: 309 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CNN2_PONPY.

Description E-value Query
Range
Subject
Range
gi|114630314 - gi|114630314|ref|XP_001156976.1| PREDICTED: similar to neutral calponin isoform 2 [Pan troglodytes]
0.0 [1..309] [1..309]
gi|60818291 - gi|60818291|gb|AAX36458.1| calponin 2 [synthetic construct]
gi|187950321, gi... - gi|49456577|emb|CAG46609.1| CNN2 [Homo sapiens], gi|187950321|gb|AAI48265.1| Calponin 2 [Homo sapien...
0.0 [1..309] [1..309]
gi|109075217, gi... - gi|109075217|ref|XP_001110816.1| PREDICTED: similar to calponin 2 isoform a isoform 4 [Macaca mulatt...
0.0 [1..309] [1..309]
CNN2_MOUSE - Calponin-2 OS=Mus musculus GN=Cnn2 PE=1 SV=1
0.0 [1..309] [1..305]
gi|60826805 - gi|60826805|gb|AAX36772.1| calponin 3 [synthetic construct]
0.0 [4..306] [2..311]

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Predicted Domain #1
Region A:
Residues: [1-159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF QKGLKDGTIL  60
   61 CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQV 120
  121 QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ ERNFDDATM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.221849
Match: 1wynA
Description: Solution structure of the CH domain of human calponin-2
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [160-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAGQCVIGLQ MGTNKCASQS GMTAYGTRRH LYDPKNHILP PMDHSTISLQ MGTNKCASQV  60
   61 GMTAPGTRRH IYDTKLGTDK C

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.522879
Match: 1ujyA
Description: Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 4.94949685871786 bayes_pls_golite062009
structural constituent of muscle 4.65743655357495 bayes_pls_golite062009
cytoskeletal protein binding 4.41722924924158 bayes_pls_golite062009
actin filament binding 3.69427077755816 bayes_pls_golite062009
binding 3.06905798270146 bayes_pls_golite062009
protein binding 2.08632303609243 bayes_pls_golite062009
signal transducer activity 1.34867629228264 bayes_pls_golite062009
molecular transducer activity 1.34867629228264 bayes_pls_golite062009
vinculin binding 1.06656350652527 bayes_pls_golite062009
transporter activity 0.896907103596953 bayes_pls_golite062009
transmembrane transporter activity 0.713068405985864 bayes_pls_golite062009
substrate-specific transporter activity 0.500685400112742 bayes_pls_golite062009
structural constituent of cytoskeleton 0.371928447183203 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.272368655500689 bayes_pls_golite062009
ion transmembrane transporter activity 0.00318812576030902 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [241-309]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNSSMSLQMG YTQGANQSGQ VFGLGRQIYD PKYCPQGTVA DGAPSGTGDC PDPGEVPEYP  60
   61 PYYQEEAGY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.290 0.004 cell-cell junction a.56.1 CO dehydrogenase ISP C-domain like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle