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View Structure Prediction Details

Protein: RhoGAP15B-PB
Organism: Drosophila melanogaster
Length: 1510 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RhoGAP15B-PB.

Description E-value Query
Range
Subject
Range
gi|125980611, gi... - gi|54642636|gb|EAL31382.1| GA18539-PA [Drosophila pseudoobscura], gi|125980611|ref|XP_001354329.1| G...
1233.0 [0..1] [1510..1]

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Predicted Domain #1
Region A:
Residues: [1-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQARPVPAP RRLYPELRPA NYENIEIRRP NSPSNNINHN NIKKLNINAE NLHGNCAEKK  60
   61 LPSSGQNKLI LQENNSDSQQ PIYGPDANEN VQEPVYATPR PAPRQRLPPA GEPEDSYPDP 120
  121 DDEVPLRILR AAPQIPPKPL NILLDQRSSI CSEVSTTSVQ TPGKADEDRE GSRYASNASL 180
  181 DCSESSHSGK FKSQSPGNLL RSLGTTSKLL GEAIGERITF KAKGAKKRLD RNFKSSTEAI 240
  241 SNIGADAGRS LKHASKRFGS NFSLGRNKDK ADIGIGGRPG GSGEMDLDRR QTMPSTEVFN 300
  301 TIQFSSPLNR NGGLPDLR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [319-533]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENDAKLQKED YLRPDPDQED DGCYEVPKTQ GKPPSYDEAL RSRPSPSDSP MSRNLAQEAA  60
   61 QLVQLRNQRQ LSSSSSNGDE SPRLPMPAFP PPRLSQQPEQ FRMDALQPPV RQKRRKNYEH 120
  121 IELRRPPVDS AQLEELNRAA AAAEREESLL ISAKNAEAET KTPKPERSDS WEFYGEDENE 180
  181 EEDRDEEQEG SSSPEPLYAN QEATYGKLFE MATAG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [534-790]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSRSNVLTPN QVAEQQQLAC ITEDSELDAC EGAVGGVPLP QAVIEEFDPL SSKCSTLARS  60
   61 NKSNELLLLE HLLEEDTYGT VKAEQDDVSM CTSEEEPTTS AATSPKPQQP QIVHQNARLL 120
  121 SDSMENMLDS DQERAKPYLS RMPESANKAS GPVDLASASR NRTNWFVPDK ASCSDVTPNT 180
  181 SKTTPPIEGD SPPTYLEAIG GSKDAAGNQE NRSTIGSRFR QTINAISNVK LKMDAMKRKA 240
  241 SFRGANQRQS DVRVALQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [791-871]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVPRPSLSPL LIRYEGPLVR FPSGVVEDIL KEMQNRKAIL RERQFQTFLD QEMKTPREMI  60
   61 PLDTITTLQC VSNSRVTDTA T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.30103
Match: 1u2bA
Description: Triglycine variant of the Grp1 Pleckstrin Homology Domain unliganded
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [872-1241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HFYCFEITTS QPKNGNGAGD AMSSNPNLLM TSSSSGNVKQ QRVSHLYGVG KESERGVWMQ  60
   61 KILESLTNSL PVKYTCHYYR AGWCYLKNSI TSEWSGTWLV LRKSQRRLIF VSEANGNVEK 120
  121 MDLRKARCIV LKESDESIDN LHVESGPMLM IDCPPYAVYM IMSSARETKI WRHIIREVAH 180
  181 NNGFSLGDQQ LTRYDVPVIV DKCINFVYIH GSMSEGIYRK SGSENSMHKL MSAFRADAFN 240
  241 VEITRNEYNE HDVANVLKRF MRDLPERLLG KLTDSFVFVT ELAVASEKIP IYRELLARLS 300
  301 AIERETLRRI VGHLVFISSQ QAKNKMSVQN LTMIWGPTLL AKKSDELIYS QKEADVLSDL 360
  361 VVLYKNLFPC 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.221849
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
enzyme activator activity 0.53004209819211 bayes_pls_golite062009
GTPase activator activity 0.528693496432149 bayes_pls_golite062009
binding 0.0980674097362609 bayes_pls_golite062009
Ras GTPase activator activity 0.0454578418356197 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1242-1510]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SADEIKREQA MLACLQKYYA AAETLKDAVK QSGDIKIWIS LNPNPENKTE EKTQVNATIS  60
   61 PTKTAYELCR EYSAKMQLPT HQLTLYEVIL NDSLERPLHH DTKVFDVILN WSYWPEEDRK 120
  121 HNYLVVRPVE MLREIQRAVK NLATVTPGKE LRFADSRTKT FKTLQCELRD GKIVVSKKDK 180
  181 NDKTTIVREI FLQSSTAYLG CERKRDFPWS WAITFVERTQ AQIMRSRDAP FIGHVLAGSE 240
  241 WGDRTIWYSS IWYCLYRDNI LPPAEIIIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.39794
Match: 2psoA
Description: No description for 2psoA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle