YRC Public Data Repository - Protein Structure Prediction

Protein:	PPAC_STRP3
Organism:	Streptococcus pyogenes serotype M3
Length:	311 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPAC_STRP3.

Description	E-value	Query Range	Subject Range
gi\|147925781, gi... - gi\|148988580\|ref\|ZP_01820013.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... gi\|148984882, gi... - gi\|148984882\|ref\|ZP_01818135.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... gi\|168575270, gi... - gi\|183578813\|gb\|EDT99341.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... gi\|168493435, gi... - gi\|183576254\|gb\|EDT96782.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... PPAC_STRPS - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain CGSP14) G... gi\|147930044, gi... - gi\|149021808\|ref\|ZP_01835815.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... PPAC_STRPI - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain Hungary19... gi\|147764203, gi... - gi\|149011772\|ref\|ZP_01832968.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... PPAC_STRPJ - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain ATCC 7006... PPAC_STRP2 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae serotype 2 (strai... gi\|149007553, gi... - gi\|149007553\|ref\|ZP_01831188.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... PPAC_STRP4 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae serotype 19F (str... gi\|148997403, gi... - gi\|148997403\|ref\|ZP_01825008.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... gi\|148992576, gi... - gi\|148992576\|ref\|ZP_01822244.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... PPAC_STRPN - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae serotype 4 (strai... PPAC_STRPN - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae GN=ppaC PE=3 SV=1 PPAC_STRR6 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain ATCC BAA-... PPAC_STRZJ - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain JJA) GN=p... PPAC_STRZP - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain P1031) GN... PPAC_STRP7 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain 70585) GN... gi\|168487504, gi... - gi\|183569687\|gb\|EDT90215.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... PPAC_STRZT - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain Taiwan19F... gi\|168484977, gi... - gi\|172041894\|gb\|EDT49940.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... gi\|242244748, gi... - gi\|242244748\|ref\|ZP_04799185.1\| manganese-dependent inorganic pyrophosphatase [Streptococcus pneumon... gi\|168491574, gi... - gi\|183574197\|gb\|EDT94725.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... gi\|183572833, gi... - gi\|183572833\|gb\|EDT93361.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd...	296.0	[0..1]	[311..1]

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Predicted Domain #1

Region A:
Residues: [1-311]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKILVFGHQ NPDTDAIASS YAFDYLSQKA FGLDTEVVAL GTPNEETAFA LDYFGVEAPR  60
   61 VVESAKAQGS EQVILTDHNE FQQSIADIRE VEVYGVVDHH RVANFETANP LYMRVEPVGS 120
  121 ASSIVYRMFK ENGIEVPKAI AGMLLSGLIS DTLLLKSPTT HVSDHLVAEE LAELAEVNLE 180
  181 DYGMALLKAG TNLASKSEVE LIGIDAKTFE LNGNAVRVAQ VNTVDIAEVL ERQEAIEAAI 240
  241 KDAMAAEGYS DFVLMITDIV NSNSEILAIG ANMDKVEAAF NFTLDNNHAF LAGAVSRKKQ 300
  301 VVPQLTESFG A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.045757
Match:	1wppA
Description:	Structure of Streptococcus gordonii inorganic pyrophosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.78154379547895	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.30887439158217	bayes_pls_golite062009
hydrolase activity	0.85363015434459	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.648027091973004	bayes_pls_golite062009
deoxyribonuclease activity	0.610962701958695	bayes_pls_golite062009
exonuclease activity	0.596639519476561	bayes_pls_golite062009
binding	0.585481144055308	bayes_pls_golite062009
nuclease activity	0.463328502877406	bayes_pls_golite062009
exodeoxyribonuclease activity	0.448568186952831	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.436324225363531	bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity	0.285695976555125	bayes_pls_golite062009
protein binding	0.0455855311641946	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: