YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|75238303, gi\|...
Organism:	Escherichia coli E110019
Length:	208 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|75238303, gi|....

Description	E-value	Query Range	Subject Range
gi\|81243115, gi\|... - gi\|82778967\|ref\|YP_405316.1\| periplasmic protein disulfide isomerase I [Shigella dysenteriae Sd197],...	173.0	[0..1]	[208..1]
DSBA_ECOL6 - Thiol:disulfide interchange protein DsbA OS=Escherichia coli O6 GN=dsbA PE=3 SV=1 DSBA_ECOL6 - Thiol:disulfide interchange protein DsbA OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UP... gi\|115515258, gi... - gi\|117626134\|ref\|YP_859457.1\| periplasmic protein disulfide isomerase I [Escherichia coli APEC O1], ... gi\|218692147, gi... - gi\|218692147\|ref\|YP_002400359.1\| periplasmic protein disulfide isomerase I [Escherichia coli ED1a], ... gi\|91074978, gi\|... - gi\|91213404\|ref\|YP_543390.1\| periplasmic protein disulfide isomerase I [Escherichia coli UTI89], gi\|... gi\|218367705, gi... - gi\|218560936\|ref\|YP_002393849.1\| periplasmic protein disulfide isomerase I [Escherichia coli S88], g... DSBA_ECO27 - Thiol:disulfide interchange protein DsbA OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=dsb... gi\|227885407, gi... - gi\|227885407\|ref\|ZP_04003212.1\| periplasmic protein disulfide isomerase I [Escherichia coli 83972], ... gi\|1040723 - gi\|1040723\|emb\|CAA90910.1\| DsbA protein [Escherichia coli] DSBA_ECO27 - Thiol:disulfide interchange protein dsbA OS=Escherichia coli O127:H6 GN=dsbA PE=3 SV=1 gi\|237702888, gi... - gi\|237702888\|ref\|ZP_04533369.1\| periplasmic protein disulfide isomerase I [Escherichia sp. 3_2_53FAA...	173.0	[0..1]	[208..1]
DSBA_SHIFL - Thiol:disulfide interchange protein DsbA OS=Shigella flexneri GN=dsbA PE=1 SV=2 gi\|24054424, gi\|... - gi\|24115149\|ref\|NP_709659.1\| periplasmic protein disulfide isomerase I [Shigella flexneri 2a str. 30... gi\|30043110, gi\|... - gi\|30064850\|ref\|NP_839021.1\| periplasmic protein disulfide isomerase I [Shigella flexneri 2a str. 24...	173.0	[0..1]	[208..1]
gi\|194418491, gi... - gi\|83569861\|ref\|ZP_00921310.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Shigella dysente...	173.0	[0..1]	[208..1]
gi\|110644199, gi... - gi\|110644199\|ref\|YP_671929.1\| periplasmic protein disulfide isomerase I [Escherichia coli 536], gi\|1... gi\|75237826, gi\|... - gi\|75237826\|ref\|ZP_00721841.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli...	172.0	[0..1]	[208..1]
gi\|1098940 - gi\|1098940\|gb\|AAC43530.1\| thiol:disulfide interchange protein DsbA mutant PH31/32PS	171.0	[0..1]	[208..1]

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Predicted Domain #1

Region A:
Residues: [1-208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKIWLALAG LVLAFSASAA QYEDGKQYTT LEKPVAGAPQ VLEFFSFFCP HCYQFEEVLH  60
   61 ISDNVKKKLP EGVKMTKYHV NFMGGDLGKD LTQAWAVAMA LGVEDKVTVP LFEGVQKTQT 120
  121 IRSASDIRDV FINAGIKGEE YDAAWNSFVV KSLVAQQEKA AADVQLRGVP AMFVNGKYQL 180
  181 NPQGMDTSNM DVFVQQYADT VKYLSEKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.522879
Match:	1a23A
Description:	SOLUTION NMR STRUCTURE OF REDUCED DSBA FROM ESCHERICHIA COLI, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein disulfide isomerase activity	1.48801287843472	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	1.48801287843472	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	1.37876060576659	bayes_pls_golite062009
catalytic activity	1.04263226837398	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.25957505753521	bayes_pls_golite062009
isomerase activity	0.24662332270942	bayes_pls_golite062009
disulfide oxidoreductase activity	0.22354310938224	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: