YRC Public Data Repository - Protein Structure Prediction

Protein:	MUTH_ECOHS
Organism:	Escherichia coli HS
Length:	229 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MUTH_ECOHS.

Description	E-value	Query Range	Subject Range
gi\|3212663\|pdb\|2... - Chain B, Dna Mismatch Repair Protein Muth From E. Coli, Chain A, Dna Mismatch Repair Protein Muth Fr... gi\|3212663, gi\|3... - gi\|3212664\|pdb\|2AZO\|B Chain B, Dna Mismatch Repair Protein Muth From E. Coli, gi\|3212663\|pdb\|2AZO\|A ...	394.0	[0..1]	[229..4]
gi\|189373841, gi... - gi\|189373841\|gb\|EDU92257.1\| DNA mismatch repair endonuclease MutH [Escherichia coli O157:H7 str. EC8... gi\|168778826, gi... - gi\|189003295\|gb\|EDU72281.1\| DNA mismatch repair endonuclease MutH [Escherichia coli O157:H7 str. EC4... gi\|208807405, gi... - gi\|208807405\|ref\|ZP_03249742.1\| DNA mismatch repair endonuclease MutH [Escherichia coli O157:H7 str.... gi\|195936435 - gi\|195936435\|ref\|ZP_03081817.1\| DNA mismatch repair protein [Escherichia coli O157:H7 str. EC4024] gi\|208819768, gi... - gi\|208819768\|ref\|ZP_03260088.1\| DNA mismatch repair endonuclease MutH [Escherichia coli O157:H7 str.... gi\|208733484, gi... - gi\|208812207\|ref\|ZP_03253536.1\| DNA mismatch repair endonuclease MutH [Escherichia coli O157:H7 str.... MUTH_ECOSE - DNA mismatch repair protein MutH OS=Escherichia coli (strain SE11) GN=mutH PE=3 SV=1 MUTH_ECO5E - DNA mismatch repair protein MutH OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=mutH PE=3 SV=... gi\|168766805, gi... - gi\|189363705\|gb\|EDU82124.1\| DNA mismatch repair endonuclease MutH [Escherichia coli O157:H7 str. EC4... gi\|189354925, gi... - gi\|189354925\|gb\|EDU73344.1\| DNA mismatch repair endonuclease MutH [Escherichia coli O157:H7 str. EC4... gi\|254594170, gi... - gi\|254794770\|ref\|YP_003079607.1\| methyl-directed mismatch repair protein [Escherichia coli O157:H7 s... MUTH_ECO8A - DNA mismatch repair protein MutH OS=Escherichia coli O8 (strain IAI1) GN=mutH PE=3 SV=1 gi\|217319314, gi... - gi\|217326947\|ref\|ZP_03443030.1\| DNA mismatch repair endonuclease MutH [Escherichia coli O157:H7 str.... MUTH_ECO7I - DNA mismatch repair protein MutH OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=mutH PE=3 SV=1 MUTH_ECO55 - DNA mismatch repair protein MutH OS=Escherichia coli (strain 55989 / EAEC) GN=mutH PE=3 SV=1 gi\|124528790, gi... - gi\|124528790\|ref\|ZP_01700014.1\| DNA mismatch repair endonuclease mutH [Escherichia coli B], gi\|12450... gi\|75230815 - gi\|75230815\|ref\|ZP_00717273.1\| COG3066: DNA mismatch repair protein [Escherichia coli B7A] MUTH_SHISS - DNA mismatch repair protein MutH OS=Shigella sonnei (strain Ss046) GN=mutH PE=3 SV=1 MUTH_ECO24 - DNA mismatch repair protein MutH OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=mutH PE=3 S... gi\|75215010 - gi\|75215010\|ref\|ZP_00713473.1\| COG3066: DNA mismatch repair protein [Escherichia coli E110019] gi\|15832942, gi\|... - gi\|15832942\|ref\|NP_311715.1\| DNA mismatch repair protein [Escherichia coli O157:H7 str. Sakai], gi\|1... MUTH_ECO57 - DNA mismatch repair protein MutH OS=Escherichia coli O157:H7 GN=mutH PE=3 SV=3 MUTH_SHIDS - DNA mismatch repair protein MutH OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=mutH PE=3 SV=1 gi\|209761010, gi... - pir\|\|C85935 methyl-directed mismatch repair [imported] - Escherichia coli (strain O157:H7, substrain... gi\|12517320, gi\|... - gi\|15803351\|ref\|NP_289384.1\| DNA mismatch repair protein [Escherichia coli O157:H7 EDL933], gi\|12517... MUTH_ECOLC - DNA mismatch repair protein MutH OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=mutH ...	394.0	[0..1]	[229..1]
MUTH_SHIB3 - DNA mismatch repair protein MutH OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=mutH... MUTH_SHIBS - DNA mismatch repair protein MutH OS=Shigella boydii serotype 4 (strain Sb227) GN=mutH PE=3 SV=1	393.0	[0..1]	[229..1]
MUTH_SALCH - DNA mismatch repair protein MutH OS=Salmonella choleraesuis (strain SC-B67) GN=mutH PE=3 SV=1 MUTH_SALCH - DNA mismatch repair protein mutH OS=Salmonella choleraesuis GN=mutH PE=3 SV=1 MUTH_SALCH - DNA mismatch repair protein mutH OS=Salmonella choleraesuis GN=mutH PE=3 SV=1 MUTH_SALPC - DNA mismatch repair protein MutH OS=Salmonella paratyphi C (strain RKS4594) GN=mutH PE=3 SV=1	392.0	[0..1]	[229..1]
gi\|194426168, gi... - gi\|75212536\|ref\|ZP_00712560.1\| COG3066: DNA mismatch repair protein [Escherichia coli B171], gi\|1944...	392.0	[0..1]	[229..1]
gi\|83569866 - gi\|83569866\|ref\|ZP_00921314.1\| COG3066: DNA mismatch repair protein [Shigella dysenteriae 1012]	392.0	[0..1]	[229..1]
MUTH_ECOK1 - DNA mismatch repair protein MutH OS=Escherichia coli O1:K1 / APEC GN=mutH PE=3 SV=1 MUTH_ECO45 - DNA mismatch repair protein MutH OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=mutH PE=3 SV=1 MUTH_ECO81 - DNA mismatch repair protein MutH OS=Escherichia coli O81 (strain ED1a) GN=mutH PE=3 SV=1 gi\|227888396, gi... - gi\|227888396\|ref\|ZP_04006201.1\| DNA mismatch repair protein [Escherichia coli 83972], gi\|227834665\|g... gi\|226899547, gi... - gi\|237706507\|ref\|ZP_04536988.1\| DNA mismatch repair protein mutH [Escherichia sp. 3_2_53FAA], gi\|226... MUTH_ECOL6 - DNA mismatch repair protein MutH OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=m... MUTH_ECOL6 - DNA mismatch repair protein mutH OS=Escherichia coli O6 GN=mutH PE=3 SV=3 MUTH_ECOUT - DNA mismatch repair protein MutH OS=Escherichia coli (strain UTI89 / UPEC) GN=mutH PE=3 SV=1 gi\|75239195 - gi\|75239195\|ref\|ZP_00723168.1\| COG3066: DNA mismatch repair protein [Escherichia coli F11]	392.0	[0..1]	[229..1]
MUTH_SALPB - DNA mismatch repair protein MutH OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mutH PE=... MUTH_SALNS - DNA mismatch repair protein MutH OS=Salmonella newport (strain SL254) GN=mutH PE=3 SV=1 MUTH_SALHS - DNA mismatch repair protein MutH OS=Salmonella heidelberg (strain SL476) GN=mutH PE=3 SV=1 gi\|194459019, gi... - gi\|194472655\|ref\|ZP_03078639.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. en... MUTH_SALSV - DNA mismatch repair protein MutH OS=Salmonella schwarzengrund (strain CVM19633) GN=mutH PE=3 SV=1 gi\|168236060, gi... - gi\|197290737\|gb\|EDY30091.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. enteri... gi\|205338005, gi... - gi\|205338005\|gb\|EDZ24769.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. enteri... gi\|168463835, gi... - gi\|195633424\|gb\|EDX51838.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. enteri... gi\|168820265, gi... - gi\|205342879\|gb\|EDZ29643.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. enteri... gi\|205324783, gi... - gi\|205324783\|gb\|EDZ12622.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. enteri... lcl\|NC_016856.1_... - [gene=mutH] [protein=DNA mismatch repair protein] [protein_id=YP_005239132.1] [location=3183190..318... MUTH_SALTY - DNA mismatch repair protein MutH OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=... gi\|167993506, gi... - gi\|205328491\|gb\|EDZ15255.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. enteri... gi\|205334442, gi... - gi\|205334442\|gb\|EDZ21206.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. enteri... gi\|204928080, gi... - gi\|204928080\|ref\|ZP_03219280.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. en... MUTH_SALG2 - DNA mismatch repair protein MutH OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=mutH PE=3 ... MUTH_SALEP - DNA mismatch repair protein MutH OS=Salmonella enteritidis PT4 (strain P125109) GN=mutH PE=3 SV=1 MUTH_SALTY - DNA mismatch repair protein mutH OS=Salmonella typhimurium GN=mutH PE=3 SV=1 MUTH_SALA4 - DNA mismatch repair protein MutH OS=Salmonella agona (strain SL483) GN=mutH PE=3 SV=1 gi\|197265268, gi... - gi\|197265268\|ref\|ZP_03165342.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. en... MUTH_SALDC - DNA mismatch repair protein MutH OS=Salmonella dublin (strain CT_02021853) GN=mutH PE=3 SV=1 gi\|200388888, gi... - gi\|200388888\|ref\|ZP_03215500.1\| DNA mismatch repair endonuclease MutH [Salmonella enterica subsp. en... gi\|238909783 - gi\|238909783\|ref\|ZP_04653620.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... MUTH_SALPB - DNA mismatch repair protein mutH OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mutH PE=... MUTH_SALTY - DNA mismatch repair protein mutH OS=Salmonella typhimurium GN=mutH PE=3 SV=1	392.0	[0..1]	[229..1]
gi\|238719552, gi... - gi\|77963209\|ref\|ZP_00827021.1\| COG3066: DNA mismatch repair protein [Yersinia mollaretii ATCC 43969]...	390.0	[0..1]	[228..1]
gi\|214000417 - gi\|214000417\|ref\|ZP_03411152.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... gi\|213976725 - gi\|213976725\|ref\|ZP_03403984.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... gi\|213861494 - gi\|213861494\|ref\|ZP_03385964.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... gi\|16761782 - gi\|16761782\|ref\|NP_457399.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica serova... MUTH_SALTI - DNA mismatch repair protein mutH OS=Salmonella typhi GN=mutH PE=3 SV=1 MUTH_SALTI - DNA mismatch repair protein MutH OS=Salmonella typhi GN=mutH PE=3 SV=1 gi\|29138900, gi\|... - gi\|29143266\|ref\|NP_806608.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica serova... gi\|213650272 - gi\|213650272\|ref\|ZP_03380325.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... gi\|213586822 - gi\|213586822\|ref\|ZP_03368648.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... gi\|213423921 - gi\|213423921\|ref\|ZP_03356901.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... gi\|213023729 - gi\|213023729\|ref\|ZP_03338176.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser...	390.0	[0..1]	[229..1]

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Predicted Domain #1

Region A:
Residues: [1-229]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQPRPLLSP PETEEQLLAQ AQQLSGYTLG ELAALVGLVT PENLKRDKGW IGVLLEIWLG  60
   61 ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL TGNSGVTWET SHVRHKLKRV 120
  121 LWIPVEGERS IPLAQRRVGS PLLWSPNEEE DRQLREDWEE LMDMIVLGQV ERITARHGEY 180
  181 LQIRPKAANA KALTEAIGAR GERILTLPRG FYLKKNFTSA LLARHFLIQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	111.0
Match:	2azoA
Description:	DNA mismatch repair protein MutH from
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
double-stranded DNA binding	4.65596322324967	bayes_pls_golite062009
endodeoxyribonuclease activity	3.88121538069074	bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity	3.87045877570028	bayes_pls_golite062009
deoxyribonuclease activity	3.62965779224499	bayes_pls_golite062009
single-stranded DNA binding	2.01277239394854	bayes_pls_golite062009
structure-specific DNA binding	1.99560174672253	bayes_pls_golite062009
nuclease activity	1.92659045080864	bayes_pls_golite062009
endonuclease activity	1.6546965422816	bayes_pls_golite062009
damaged DNA binding	1.50475020123562	bayes_pls_golite062009
hydrolase activity	1.18004254197954	bayes_pls_golite062009
binding	0.940513659936693	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.878597940882332	bayes_pls_golite062009
catalytic activity	0.816447099398022	bayes_pls_golite062009
nucleic acid binding	0.796780585758145	bayes_pls_golite062009
DNA binding	0.779318309058729	bayes_pls_golite062009
protein binding	0.458550636208588	bayes_pls_golite062009
DNA strand annealing activity	0.103710151681167	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: