YRC Public Data Repository - Protein Structure Prediction

Protein:	HTPX_SALPA
Organism:	Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Length:	293 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HTPX_SALPA.

Description	E-value	Query Range	Subject Range
HTPX_ERWCT - Protease HtpX OS=Erwinia carotovora subsp. atroseptica GN=htpX PE=3 SV=1 HTPX_PECAS - Protease HtpX OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=htpX PE=3 SV=1	4.0E-66	[1..293]	[1..293]
gi\|194417239, gi... - gi\|83569085\|ref\|ZP_00920546.1\| COG0501: Zn-dependent protease with chaperone function [Shigella dyse...	4.0E-66	[1..293]	[1..293]
gi\|188013563, gi... - gi\|188013563\|gb\|EDU51685.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4113], gi\|1687526... gi\|168758592, gi... - gi\|189354623\|gb\|EDU73042.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4401], gi\|1687585... gi\|189360375, gi... - gi\|189360375\|gb\|EDU78794.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4486], gi\|1687708... gi\|188999448, gi... - gi\|188999448\|gb\|EDU68434.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4076], gi\|1687831... gi\|254793453, gi... - gi\|254793453\|ref\|YP_003078290.1\| predicted endopeptidase [Escherichia coli O157:H7 str. TW14359], gi... gi\|193066804, gi... - gi\|75254939\|ref\|ZP_00726891.1\| COG0501: Zn-dependent protease with chaperone function [Escherichia c... HTPX_ECOLC - Protease HtpX OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=htpX PE=3 SV=1 gi\|237705781, gi... - gi\|237705781\|ref\|ZP_04536262.1\| heat shock protein HtpX [Escherichia sp. 3_2_53FAA], gi\|226900538\|gb... HTPX_SHISS - Protease HtpX OS=Shigella sonnei (strain Ss046) GN=htpX PE=3 SV=1 gi\|227885744, gi... - gi\|227885744\|ref\|ZP_04003549.1\| M48 family endopeptidase HtpX [Escherichia coli 83972], gi\|227837317... gi\|75208008, gi\|... - gi\|75208008\|ref\|ZP_00708426.1\| COG0501: Zn-dependent protease with chaperone function [Escherichia c... gi\|75239751 - gi\|75239751\|ref\|ZP_00723714.1\| COG0501: Zn-dependent protease with chaperone function [Escherichia c... HTPX_SHIDS - Protease HtpX OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=htpX PE=3 SV=1 HTPX_SHIBS - Protease HtpX OS=Shigella boydii serotype 4 (strain Sb227) GN=htpX PE=3 SV=1 HTPX_ECO57 - Protease HtpX OS=Escherichia coli O157:H7 GN=htpX PE=2 SV=1 gi\|217317954, gi... - gi\|217328607\|ref\|ZP_03444688.1\| M48B family peptidase [Escherichia coli O157:H7 str. TW14588], gi\|21... HTPX_ECOL6 - Protease HtpX OS=Escherichia coli O6 GN=htpX PE=3 SV=1 HTPX_ECO8A - Protease HtpX OS=Escherichia coli O8 (strain IAI1) GN=htpX PE=3 SV=1 HTPX_ECO45 - Protease HtpX OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=htpX PE=3 SV=1 HTPX_ECO81 - Protease HtpX OS=Escherichia coli O81 (strain ED1a) GN=htpX PE=3 SV=1 HTPX_ECO24 - Protease HtpX OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=htpX PE=3 SV=1 HTPX_ECO55 - Protease HtpX OS=Escherichia coli (strain 55989 / EAEC) GN=htpX PE=3 SV=1 HTPX_ECOHS - Protease HtpX OS=Escherichia coli O9:H4 (strain HS) GN=htpX PE=3 SV=1 HTPX_ECO7I - Protease HtpX OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=htpX PE=3 SV=1 HTPX_ECOLU - Protease HtpX OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=htpX PE=3 SV=1 HTPX_SHIB3 - Protease HtpX OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=htpX PE=3 SV=1 HTPX_ECOK1 - Protease HtpX OS=Escherichia coli O1:K1 / APEC GN=htpX PE=3 SV=1 HTPX_ECOSM - Protease HtpX OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=htpX PE=3 SV=1 gi\|124498872, gi... - gi\|124530977\|ref\|ZP_01701433.1\| HtpX domain protein [Escherichia coli B], gi\|124498872\|gb\|EAY46373.1... gi\|170769359, gi... - gi\|170769359\|ref\|ZP_02903812.1\| M48B family peptidase [Escherichia albertii TW07627], gi\|170121683\|g... gi\|188488604, gi... - gi\|188493405\|ref\|ZP_03000675.1\| M48B family peptidase HtpX [Escherichia coli 53638], gi\|188488604\|gb... gi\|208810633, gi... - gi\|208810633\|ref\|ZP_03252509.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4206], gi\|208... gi\|208731013, gi... - gi\|208816670\|ref\|ZP_03257790.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4045], gi\|208... gi\|208741454, gi... - gi\|208821331\|ref\|ZP_03261651.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4042], gi\|208... HTPX_ECO5E - Protease HtpX OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=htpX PE=3 SV=1 HTPX_ECOSE - Protease HtpX OS=Escherichia coli (strain SE11) GN=htpX PE=3 SV=1 HTPX_ECOUT - Protease HtpX OS=Escherichia coli (strain UTI89 / UPEC) GN=htpX PE=3 SV=1 HTPX_SHIFL - Protease HtpX OS=Shigella flexneri GN=htpX PE=3 SV=1 gi\|15831793, gi\|... - gi\|15831793\|ref\|NP_310566.1\| heat shock protein HtpX [Escherichia coli O157:H7 str. Sakai], gi\|13362... HTPX_ECOL5 - Protease HtpX OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=htpX PE=3 SV=1 HTPX_SHIF8 - Protease HtpX OS=Shigella flexneri serotype 5b (strain 8401) GN=htpX PE=3 SV=1 gi\|24112780, gi\|... - ref\|NP_707290.1\| heat shock protein HtpX [Shigella flexneri 2a str. 301], gb\|AAN42997.1\| heat shock... HTPX_ECOL6 - Protease HtpX OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=htpX PE=3 SV=1 gi\|209767788, gi... - pir\|\|C90946 heat shock protein HtpX [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0...	4.0E-66	[1..293]	[1..293]
gi\|25296090 - gi\|25296090\|pir\|\|G85794 heat shock protein, integral membrane protein [imported] - Escherichia coli ... gi\|15802243, gi\|... - gi\|15802243\|ref\|NP_288266.1\| heat shock protein HtpX [Escherichia coli O157:H7 EDL933], gi\|12515876\|...	5.0E-66	[1..293]	[1..293]
gi\|238724840, gi... - gi\|77975215\|ref\|ZP_00830751.1\| COG0501: Zn-dependent protease with chaperone function [Yersinia fred...	6.0E-66	[1..293]	[1..293]
gi\|254288677, gi... - gi\|254288677\|ref\|YP_003054425.1\| heat shock protein HtpX [Escherichia coli BL21(DE3)], gi\|253977984\|... gi\|83584508, gi\|... - gi\|83584508\|ref\|ZP_00923186.1\| COG0501: Zn-dependent protease with chaperone function [Escherichia c... gi\|242377550, gi... - gi\|251785277\|ref\|YP_002999581.1\| hypothetical protein B21_01788 [Escherichia coli BL21], gi\|24237755... gi\|254161889, gi... - gi\|254161889\|ref\|YP_003044997.1\| heat shock protein HtpX [Escherichia coli B str. REL606], gi\|253973...	6.0E-66	[1..293]	[1..293]
gi\|89108669, gi\|... - gi\|89108669\|ref\|AP_002449.1\| predicted endopeptidase [Escherichia coli str. K-12 substr. W3110], gi\|... HTPX_ECOLI - Probable protease htpX (EC 3.4.24.-) (Heat shock protein htpX) - Escherichia coli EG10462 - putative endopeptidase / Zinc metalloprotease HtpX, membrane-bound; cleaves SecY in vivo and in vitr... HTPX_ECOBW - Protease HtpX OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=htpX PE=3 SV=1 HTPX_ECODH - Protease HtpX OS=Escherichia coli (strain K12 / DH10B) GN=htpX PE=3 SV=1 EG10462 - putative endopeptidase / Zinc metalloprotease HtpX, membrane-bound; cleaves SecY in vivo and in vitr...	7.0E-66	[1..293]	[1..293]
gi\|238728851, gi... - gi\|77980102\|ref\|ZP_00835517.1\| COG0501: Zn-dependent protease with chaperone function [Yersinia inte...	2.0E-65	[1..293]	[1..293]
gi\|56479890, gi\|... - gi\|56479890\|ref\|NP_707290.2\| heat shock protein HtpX [Shigella flexneri 2a str. 301], gi\|56383441\|gb... gi\|30062915, gi\|... - gi\|30062915\|ref\|NP_837086.1\| heat shock protein HtpX [Shigella flexneri 2a str. 2457T], gi\|30041164\|... gi\|195939730 - gi\|195939730\|ref\|ZP_03085112.1\| heat shock protein HtpX [Escherichia coli O157:H7 str. EC4024]	2.0E-65	[2..293]	[1..292]
gi\|238798125, gi... - gi\|77961603\|ref\|ZP_00825437.1\| COG0501: Zn-dependent protease with chaperone function [Yersinia moll...	3.0E-65	[1..293]	[1..293]

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Predicted Domain #1

Region A:
Residues: [1-70]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRIALFLLT NLAVMVVFGL VLSLTGIQSS SVQGLLIMAL LFGFGGSFIS LLMSKWMALK  60
   61 SVGGEVIEQP

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	20.327902
Match:	PF06509.2
Description:	No description for PF06509.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [71-147]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNERERWLMN TVATQARQAG IAMPQVAIYH APDINAFATG ARRDASLVAV STGLLQNMSP  60
   61 DEAEAVIAHE ISHIANG

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.01
Match:	1c7kA
Description:	Zinc protease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.52170890235712	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.20265930105587	bayes_pls_golite062009
metallopeptidase activity	2.46762211541241	bayes_pls_golite062009
hydrolase activity	2.3590043825345	bayes_pls_golite062009
endopeptidase activity	2.3107572739426	bayes_pls_golite062009
metalloendopeptidase activity	1.69802747425985	bayes_pls_golite062009
catalytic activity	0.843772148375291	bayes_pls_golite062009
binding	0.655247478888488	bayes_pls_golite062009
protein binding	0.273409914175328	bayes_pls_golite062009
exopeptidase activity	0.160545038651425	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [148-293]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMVTMTLIQG VVNTFVIFIS RIIAQIAAGF LGGNRDEGEG SNGNPLIYFA VATVLELVFG  60
   61 ILASIITMWF SRYREFHADA GSAKLVGREK MIAALQRLKT SYEPQEATSM MAFCINGKSK 120
  121 SLSELFMTHP PLDKRIEALR SGEYLK

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	3.958607
Match:	PF01435.9
Description:	No description for PF01435.9 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: