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View Structure Prediction Details

Protein: slik-PE
Organism: Drosophila melanogaster
Length: 1342 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for slik-PE.

Description E-value Query
Range
Subject
Range
slik-PD, slik-PB - The gene Sterile20-like kinase is referred to in FlyBase by the symbol Dmel\slik (CG4527, FBgn003500...
441.0 [0..1] [1325..1]

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Predicted Domain #1
Region A:
Residues: [1-364]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFITNLKKV FHLGGGEAKK KRLYNNIKMD TDPAEFWEMV GELGDGAFGK VYKAQHKEQK  60
   61 RFAAAKMCQL EDEENLSDHM VEIDILSEIK HPNIVELYEA FSIDDKLWML IEYCDGGALD 120
  121 SIMVELEKPL TEPQIAYVCK HMTEGLTFLH RNKVIHRDLK AGNVLLTMEG GVKLADFGVS 180
  181 AKNKHTMQKH DTFIGTPYWM APELVLCETF RDNPYDHKVD IWSLGITLIE LAQMEPPNSE 240
  241 MSPMRVLLKI QKSEPPKLEQ PSRWSKEFND FLKKSLVKDP QVRPTTDVLM QHAFINRNLD 300
  301 AKPIKDLLLE YKAEVVEEVV DDETEEPRNS ALQLDLDDDS ASLQSQDIDK LPGTPTSILR 360
  361 DAKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.39794
Match: 2j51A
Description: No description for 2j51A was found.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
fibroblast growth factor receptor activity 2.07350687583102 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
fibroblast growth factor binding 1.46046123990071 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.41172362253967 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.32254739984688 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.0383359654359 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
nucleic acid binding 0.794058505655489 bayes_pls_golite062009
transcription regulator activity 0.775404673285876 bayes_pls_golite062009
DNA binding 0.714163549867672 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
insulin receptor substrate binding 0.57867852584301 bayes_pls_golite062009
transcription factor activity 0.563262875317016 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
transcription activator activity 0.481994471237116 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.391384757497683 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
pyrophosphatase activity 0.351206771811872 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.340617390162297 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.339969855367828 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [365-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSQPSSSLPI AAAATAAAAA TTTTKATTPD RPNHTKDDNA EAAAQQPPHT KVPAPAPPSS  60
   61 QQTPPPQVQQ 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [435-680]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPTPPAQPTA AVLQKKPEDV AAVAETSEKT ESDKKHFVKK GKAPPPPSPL GLANAKPAAS  60
   61 DSQTSPKKLA TPEPTSPVTT AIEVAIGQEA MEPKPQPPSP TASSIVSVQS VASSSSSGSV 120
  121 SNAVLSSSTS LITINSDPPT PHHHQPLPPQ PQHLILPNSL ESVSQITVVT STHPPVIIDN 180
  181 SVMPPQNEVI IVSNDMNKST HLHESSTDDD FPSLDDSLGD ATTPPHKQSS MILAVNEPAG 240
  241 VVPAPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [681-1342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQPQTSSTVH ARKLDESEVL IVSPSYADDD SAYNTASGSH SHDHSDHLMD TSHVSVVTVG  60
   61 DEGVKVKDSS NELVKRQPNG VGIVPEDVNI IVNRFKQEKR SPDSSLSENG SVRGRRGIEV 120
  121 LVGGSGGSDV DSIGTNTSQE SRHETDHNNK QQYPAAALMP PPPPSLTNNH NHETIDEEEE 180
  181 VVIRPKARVP AVVKSANAQG LTKEEIELRN LRKKTRKRTR KFEIDGVQMT TTTSRVIYGD 240
  241 DENGRIYDDH DFRKQELREL KLLQKQEKKQ QTELHLKEQQ AKEQQDRRFE QERSSLEKTY 300
  301 EADMDMLARQ HKQLVEKTEQ TQENELRSSS KRIRSEQEQE LKIFRENLKQ EIRLLKQEVD 360
  361 LFPKDKRKDE FKQRRSAMEL DHEEKERAFL DSLKERHELL LRRLSEKHRD HLATINRNFL 420
  421 QQKQNAMRTR EALLWELEEK QLHERHQLSK RHVKELCFMQ RHQMIIRHEK ELDQVKRMLQ 480
  481 RKEEDMVKKQ TMEKRALPKR IRAERKARDL MFRESLRIST NLDPEIERDR LKKFQEQEKK 540
  541 RYMQEERRFE VKHQKQLEEL RATRESAIKE LEQLQNEKRR ALVEHEHSKL SEIDERLKGE 600
  601 LREWREQLVP RKQRLEETFA QQLDEMETLY GGALIVSMPS DTLQRDHFTG STRSSLSSYS 660
  661 EG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.154902
Match: 2dfsA
Description: No description for 2dfsA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle