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View Structure Prediction Details

Protein: TEF1, TEF2
Organism: Saccharomyces cerevisiae
Length: 458 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TEF1, TEF2.

Description E-value Query
Range
Subject
Range
gi|169409549 - gi|169409549|gb|ACA57895.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Calliceb...
EF1A1_PANTR - Elongation factor 1-alpha 1 OS=Pan troglodytes GN=EEF1A1 PE=2 SV=1
gi|163781003 - gi|163781003|gb|ABY40784.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Papio an...
gi|67970565 - gi|67970565|dbj|BAE01625.1| unnamed protein product [Macaca fascicularis]
EF1A1_PONAB - Elongation factor 1-alpha 1 OS=Pongo abelii GN=EEF1A1 PE=2 SV=2
EEF1A1 - eukaryotic translation elongation factor 1 alpha 1
gi|60819043, gi|... - gi|61363070|gb|AAX42329.1| eukaryotic translation elongation factor 1 alpha 1 [synthetic construct],...
gi|73973292 - gi|73973292|ref|XP_532203.2| PREDICTED: similar to eukaryotic translation elongation factor 1 alpha ...
gi|229368700 - gi|229368700|gb|ACQ62985.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Dasypus ...
tr|F6UME7|F6UME7... - Elongation factor 1-alpha OS=Equus caballus OX=9796 GN=EEF1A1 PE=3 SV=1
gi|56342332|dbj|... - eukaryotic translation elongation factor 1 alpha 1 [Pan troglodytes]
EF1A1_BOVIN - Elongation factor 1-alpha 1 OS=Bos taurus GN=EEF1A1 PE=1 SV=1
EF1A1_PONPY - Elongation factor 1-alpha 1 - Pongo pygmaeus (Orangutan)
EF1A1_RABIT - Elongation factor 1-alpha 1 OS=Oryctolagus cuniculus GN=EEF1A1 PE=1 SV=1
gi|109071708, gi... - gi|109071710|ref|XP_001112777.1| PREDICTED: similar to eukaryotic translation elongation factor 1 al...
EF1A1_FELCA - Elongation factor 1-alpha 1 OS=Felis catus GN=EEF1A1 PE=2 SV=1
gi|223019597, gi... - gi|223019599|emb|CAX36487.1| eukaryotic translation elongation factor 1 alpha 1 [Sus scrofa], gi|223...
ENSCJAT00000019570 - null
0.0 [1..457] [1..460]
EF1A_CHICK - Elongation factor 1-alpha 1 OS=Gallus gallus GN=EEF1A PE=2 SV=1
0.0 [1..457] [1..460]
EF1A1_RAT - Elongation factor 1-alpha 1 OS=Rattus norvegicus GN=Eef1a1 PE=2 SV=1
gi|190344037 - gi|190344037|gb|ACE75815.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Sorex ar...
EF1A1_MOUSE - Elongation factor 1-alpha 1 OS=Mus musculus GN=Eef1a1 PE=1 SV=3
gi|183398094 - gi|183398094|gb|ACC62508.1| elongation factor 1 alpha (predicted) [Rhinolophus ferrumequinum]
gi|220279 - gi|220279|dbj|BAA00409.1| EF-1 alpha [Cricetulus longicaudatus]
EF1A1_CRIGR - Elongation factor 1-alpha 1 OS=Cricetulus griseus GN=EEF1A1 PE=2 SV=1
gi|53734423 - gb|AAH84017.1| Unknown (protein for MGC:98187) [Xenopus laevis]
0.0 [1..457] [1..460]
gi|15805031, gi|... - gi|15805031|ref|NP_284925.1| eukaryotic translation elongation factor 1 alpha 2 [Rattus norvegicus],...
0.0 [1..457] [1..460]
EF1A0_XENLA - Elongation factor 1-alpha, somatic form OS=Xenopus laevis GN=eef1as PE=2 SV=1
0.0 [1..457] [1..460]

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Predicted Domain #1
Region A:
Residues: [1-33]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKEKSHINV VVIGHVDSGK STTTGHLIYK CGG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [76-237]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALWKFETPKY QVTVIDAPGH RDFIKNMITG TSQADCAILI IAGGVGEFEA GISKDGQTRE  60
   61 HALLAFTLGV RQLIVAVNKM DSVKWDESRF QEIVKETSNF IKKVGYNPKT VPFVPISGWN 120
  121 GDNMIEATTN APWYKGWEKE TKAGVVKGKT LLEAIDAIEQ PS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1f60A_
Description: Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation elongation factor activity 8.90683166637832 bayes_pls_golite062009
translation factor activity, nucleic acid binding 4.8378725567094 bayes_pls_golite062009
translation regulator activity 4.79814772079421 bayes_pls_golite062009
structural constituent of ribosome 4.56509805974548 bayes_pls_golite062009
structural molecule activity 3.58406348799895 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
translation release factor activity 2.49148102494524 bayes_pls_golite062009
translation termination factor activity 2.46464632547226 bayes_pls_golite062009
primary active transmembrane transporter activity 2.39629638016861 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.39600931083427 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.36051733655256 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.35906629925754 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.35679406876731 bayes_pls_golite062009
RNA binding 2.29590582680214 bayes_pls_golite062009
ATPase activity, coupled 2.24901251684901 bayes_pls_golite062009
actin filament binding 2.1683792904715 bayes_pls_golite062009
2.15810909411803 bayes_pls_golite062009
motor activity 2.11140484670646 bayes_pls_golite062009
substrate-specific transporter activity 1.65609907941094 bayes_pls_golite062009
nucleic acid binding 1.49633029954726 bayes_pls_golite062009
actin binding 1.42666717383185 bayes_pls_golite062009
cytoskeletal protein binding 1.40488517180956 bayes_pls_golite062009
microtubule motor activity 1.35938517416356 bayes_pls_golite062009
microfilament motor activity 1.33993901826495 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.3182108176243 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription regulator activity 0.989226939888218 bayes_pls_golite062009
ATP binding 0.98146619596929 bayes_pls_golite062009
DNA binding 0.967303417236485 bayes_pls_golite062009
adenyl ribonucleotide binding 0.949788783884952 bayes_pls_golite062009
adenyl nucleotide binding 0.931486373329219 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
mRNA binding 0.76699944561918 bayes_pls_golite062009
peptidyltransferase activity 0.705667095586631 bayes_pls_golite062009
ion transmembrane transporter activity 0.704934361725919 bayes_pls_golite062009
kinase activity 0.691112783105676 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
RNA helicase activity 0.6022754485555 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.499834566483656 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 0.353150780751661 bayes_pls_golite062009
guanyl nucleotide binding 0.296406132096546 bayes_pls_golite062009
GTP binding 0.295705904888768 bayes_pls_golite062009
guanyl ribonucleotide binding 0.29028316917561 bayes_pls_golite062009
cation transmembrane transporter activity 0.282397764628576 bayes_pls_golite062009
ribonuclease activity 0.222424272323909 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.12168417344278 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.0716139935283535 bayes_pls_golite062009
transcription factor activity 0.0434163635422169 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0430764033739892 bayes_pls_golite062009
protein transporter activity 0.0397092337273124 bayes_pls_golite062009
protein transmembrane transporter activity 0.0378638259240902 bayes_pls_golite062009
protein kinase activity 0.0364322017534667 bayes_pls_golite062009
peptide transporter activity 0.0135927378126404 bayes_pls_golite062009
signal sequence binding 6.53725193420218E-4 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [34-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDKRTIEKFE KEAAELGKGS FKYAWVLDKL KAERERGITI DI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [238-332]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPTDKPLRLP LQDVYKIGGI GTVPVGRVET GVIKPGMVVT FAPAGVTTEV KSVEMHHEQL  60
   61 EQGVPGDNVG FNVKNVSVKE IRRGNVCGDA KNDPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1f60A_
Description: Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [333-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGCASFNATV IVLNHPGQIS AGYSPVLDCH TAHIACRFDE LLEKNDRRSG KKLEDHPKFL  60
   61 KSGDAALVKF VPSKPMCVEA FSEYPPLGRF AVRDMRQTVA VGVIKSVDKT EKAAKVTKAA 120
  121 QKAAKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1f60A_
Description: Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle