YRC Public Data Repository - Protein Structure Prediction

Protein:	TEF1, TEF2
Organism:	Saccharomyces cerevisiae
Length:	458 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TEF1, TEF2.

Description	E-value	Query Range	Subject Range
gi\|169409549 - gi\|169409549\|gb\|ACA57895.1\| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Calliceb... EF1A1_PANTR - Elongation factor 1-alpha 1 OS=Pan troglodytes GN=EEF1A1 PE=2 SV=1 gi\|163781003 - gi\|163781003\|gb\|ABY40784.1\| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Papio an... gi\|67970565 - gi\|67970565\|dbj\|BAE01625.1\| unnamed protein product [Macaca fascicularis] EF1A1_PONAB - Elongation factor 1-alpha 1 OS=Pongo abelii GN=EEF1A1 PE=2 SV=2 EEF1A1 - eukaryotic translation elongation factor 1 alpha 1 gi\|60819043, gi\|... - gi\|61363070\|gb\|AAX42329.1\| eukaryotic translation elongation factor 1 alpha 1 [synthetic construct],... gi\|73973292 - gi\|73973292\|ref\|XP_532203.2\| PREDICTED: similar to eukaryotic translation elongation factor 1 alpha ... gi\|229368700 - gi\|229368700\|gb\|ACQ62985.1\| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Dasypus ... tr\|F6UME7\|F6UME7... - Elongation factor 1-alpha OS=Equus caballus OX=9796 GN=EEF1A1 PE=3 SV=1 gi\|56342332\|dbj\|... - eukaryotic translation elongation factor 1 alpha 1 [Pan troglodytes] EF1A1_BOVIN - Elongation factor 1-alpha 1 OS=Bos taurus GN=EEF1A1 PE=1 SV=1 EF1A1_PONPY - Elongation factor 1-alpha 1 - Pongo pygmaeus (Orangutan) EF1A1_RABIT - Elongation factor 1-alpha 1 OS=Oryctolagus cuniculus GN=EEF1A1 PE=1 SV=1 gi\|109071708, gi... - gi\|109071710\|ref\|XP_001112777.1\| PREDICTED: similar to eukaryotic translation elongation factor 1 al... EF1A1_FELCA - Elongation factor 1-alpha 1 OS=Felis catus GN=EEF1A1 PE=2 SV=1 gi\|223019597, gi... - gi\|223019599\|emb\|CAX36487.1\| eukaryotic translation elongation factor 1 alpha 1 [Sus scrofa], gi\|223... ENSCJAT00000019570 - null	0.0	[1..457]	[1..460]
EF1A_CHICK - Elongation factor 1-alpha 1 OS=Gallus gallus GN=EEF1A PE=2 SV=1	0.0	[1..457]	[1..460]
EF1A1_RAT - Elongation factor 1-alpha 1 OS=Rattus norvegicus GN=Eef1a1 PE=2 SV=1 gi\|190344037 - gi\|190344037\|gb\|ACE75815.1\| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Sorex ar... EF1A1_MOUSE - Elongation factor 1-alpha 1 OS=Mus musculus GN=Eef1a1 PE=1 SV=3 gi\|183398094 - gi\|183398094\|gb\|ACC62508.1\| elongation factor 1 alpha (predicted) [Rhinolophus ferrumequinum] gi\|220279 - gi\|220279\|dbj\|BAA00409.1\| EF-1 alpha [Cricetulus longicaudatus] EF1A1_CRIGR - Elongation factor 1-alpha 1 OS=Cricetulus griseus GN=EEF1A1 PE=2 SV=1 gi\|53734423 - gb\|AAH84017.1\| Unknown (protein for MGC:98187) [Xenopus laevis]	0.0	[1..457]	[1..460]
gi\|15805031, gi\|... - gi\|15805031\|ref\|NP_284925.1\| eukaryotic translation elongation factor 1 alpha 2 [Rattus norvegicus],...	0.0	[1..457]	[1..460]
EF1A0_XENLA - Elongation factor 1-alpha, somatic form OS=Xenopus laevis GN=eef1as PE=2 SV=1	0.0	[1..457]	[1..460]

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Predicted Domain #1

Region A:
Residues: [1-33]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKEKSHINV VVIGHVDSGK STTTGHLIYK CGG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [76-237]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALWKFETPKY QVTVIDAPGH RDFIKNMITG TSQADCAILI IAGGVGEFEA GISKDGQTRE  60
   61 HALLAFTLGV RQLIVAVNKM DSVKWDESRF QEIVKETSNF IKKVGYNPKT VPFVPISGWN 120
  121 GDNMIEATTN APWYKGWEKE TKAGVVKGKT LLEAIDAIEQ PS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1f60A_
Description:	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation elongation factor activity	8.90683166637832	bayes_pls_golite062009
translation factor activity, nucleic acid binding	4.8378725567094	bayes_pls_golite062009
translation regulator activity	4.79814772079421	bayes_pls_golite062009
structural constituent of ribosome	4.56509805974548	bayes_pls_golite062009
structural molecule activity	3.58406348799895	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
hydrolase activity	2.55157966585974	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
translation release factor activity	2.49148102494524	bayes_pls_golite062009
translation termination factor activity	2.46464632547226	bayes_pls_golite062009
primary active transmembrane transporter activity	2.39629638016861	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.39600931083427	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.36051733655256	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.35906629925754	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.35679406876731	bayes_pls_golite062009
RNA binding	2.29590582680214	bayes_pls_golite062009
ATPase activity, coupled	2.24901251684901	bayes_pls_golite062009
actin filament binding	2.1683792904715	bayes_pls_golite062009
	2.15810909411803	bayes_pls_golite062009
motor activity	2.11140484670646	bayes_pls_golite062009
substrate-specific transporter activity	1.65609907941094	bayes_pls_golite062009
nucleic acid binding	1.49633029954726	bayes_pls_golite062009
actin binding	1.42666717383185	bayes_pls_golite062009
cytoskeletal protein binding	1.40488517180956	bayes_pls_golite062009
microtubule motor activity	1.35938517416356	bayes_pls_golite062009
microfilament motor activity	1.33993901826495	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.3182108176243	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription regulator activity	0.989226939888218	bayes_pls_golite062009
ATP binding	0.98146619596929	bayes_pls_golite062009
DNA binding	0.967303417236485	bayes_pls_golite062009
adenyl ribonucleotide binding	0.949788783884952	bayes_pls_golite062009
adenyl nucleotide binding	0.931486373329219	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
protein methyltransferase activity	0.876296121718575	bayes_pls_golite062009
mRNA binding	0.76699944561918	bayes_pls_golite062009
peptidyltransferase activity	0.705667095586631	bayes_pls_golite062009
ion transmembrane transporter activity	0.704934361725919	bayes_pls_golite062009
kinase activity	0.691112783105676	bayes_pls_golite062009
histone methyltransferase activity	0.63002958837536	bayes_pls_golite062009
RNA helicase activity	0.6022754485555	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.499834566483656	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	0.353150780751661	bayes_pls_golite062009
guanyl nucleotide binding	0.296406132096546	bayes_pls_golite062009
GTP binding	0.295705904888768	bayes_pls_golite062009
guanyl ribonucleotide binding	0.29028316917561	bayes_pls_golite062009
cation transmembrane transporter activity	0.282397764628576	bayes_pls_golite062009
ribonuclease activity	0.222424272323909	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.12168417344278	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.0716139935283535	bayes_pls_golite062009
transcription factor activity	0.0434163635422169	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0430764033739892	bayes_pls_golite062009
protein transporter activity	0.0397092337273124	bayes_pls_golite062009
protein transmembrane transporter activity	0.0378638259240902	bayes_pls_golite062009
protein kinase activity	0.0364322017534667	bayes_pls_golite062009
peptide transporter activity	0.0135927378126404	bayes_pls_golite062009
signal sequence binding	6.53725193420218E-4	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [34-75]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDKRTIEKFE KEAAELGKGS FKYAWVLDKL KAERERGITI DI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [238-332]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPTDKPLRLP LQDVYKIGGI GTVPVGRVET GVIKPGMVVT FAPAGVTTEV KSVEMHHEQL  60
   61 EQGVPGDNVG FNVKNVSVKE IRRGNVCGDA KNDPP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1f60A_
Description:	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [333-458]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGCASFNATV IVLNHPGQIS AGYSPVLDCH TAHIACRFDE LLEKNDRRSG KKLEDHPKFL  60
   61 KSGDAALVKF VPSKPMCVEA FSEYPPLGRF AVRDMRQTVA VGVIKSVDKT EKAAKVTKAA 120
  121 QKAAKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1f60A_
Description:	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: