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View Structure Prediction Details

Protein: MCD1
Organism: Saccharomyces cerevisiae
Length: 566 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCD1.

Description E-value Query
Range
Subject
Range
SCC1_YEAST - Sister chromatid cohesion protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCD1...
MCD1 - Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meios...
0.0 [1..566] [1..566]
SCC11_ARATH - Sister chromatid cohesion 1 protein 1 OS=Arabidopsis thaliana GN=SYN1 PE=2 SV=2
0.0 [14..557] [17..625]
gi|208965416 - gi|208965416|dbj|BAG72722.1| RAD21 homolog [synthetic construct]
gi|114621389, gi... - gi|114621399|ref|XP_001138797.1| PREDICTED: RAD21 homolog isoform 8 [Pan troglodytes], gi|114621397|...
RAD21 - RAD21 homolog (S. pombe)
1.0E-92 [14..375] [7..347]
RAD21_MOUSE, RA2... - Double-strand-break repair protein rad21 homolog OS=Mus musculus GN=Rad21 PE=1 SV=2, (Q61550) Double...
1.0E-90 [14..375] [7..347]

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Predicted Domain #1
Region A:
Residues: [1-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTENPQRLT VLRLATNKGP LAQIWLASNM SNIPRGSVIQ THIAESAKEI AKASGCDDES  60
   61 GDNEYITLRT SGELLQGIVR VYSKQATFLL TDIKDTLTKI SMLFKTSQKM TSTVNRLNTV 120
  121 TRVHQLMLED AVTEREVLVT PGLEFLDDTT IPVGLMAQEN SMERKVQGAA PWDTSLEVGR 180
  181 RFSPDEDFEH NNLSSMNLDF DIEEGPITSK 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [211-566]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SWEEGTRQSS RNFDTHENYI QDDDFPLDDA GTIGWDLGIT EKNDQNNDDD DNSVEQGRRL  60
   61 GESIMSEEPT DFGFDLDIEK EAPAGNIDTI TDAMTESQPK QTGTRRNSKL LNTKSIQIDE 120
  121 ETENSESIAS SNTYKEERSN NLLTPQPTNF TTKRLWSEIT ESMSYLPDPI LKNFLSYESL 180
  181 KKRKIHNGRE GSIEEPELNV SLNLTDDVIS NAGTNDNSFN ELTDNMSDFV PIDAGLNEAP 240
  241 FPEENIIDAK TRNEQTTIQT EKVRPTPGEV ASKAIVQMAK ILRKELSEEK EVIFTDVLKS 300
  301 QANTEPENIT KREASRGFFD ILSLATEGCI GLSQTEAFGN IKIDAKPALF ERFINA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [219-380]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSRNFDTHEN YIQDDDFPLD DAGTIGWDLG ITEKNDQNND DDDNSVEQGR RLGESIMSEE  60
   61 PTDFGFDLDI EKEAPAGNID TITDAMTESQ PKQTGTRRNS KLLNTKSIQI DEETENSESI 120
  121 ASSNTYKEER SNNLLTPQPT NFTTKRLWSE ITESMSYLPD PI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [381-566]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKNFLSYESL KKRKIHNGRE GSIEEPELNV SLNLTDDVIS NAGTNDNSFN ELTDNMSDFV  60
   61 PIDAGLNEAP FPEENIIDAK TRNEQTTIQT EKVRPTPGEV ASKAIVQMAK ILRKELSEEK 120
  121 EVIFTDVLKS QANTEPENIT KREASRGFFD ILSLATEGCI GLSQTEAFGN IKIDAKPALF 180
  181 ERFINA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.045757
Match: 1w1wE
Description: Sc Smc1hd:Scc1-C complex, ATPgS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 3.84008666671174 bayes_pls_golite062009
binding 3.38086362981788 bayes_pls_golite062009
transcription regulator activity 2.53725013788849 bayes_pls_golite062009
nucleic acid binding 2.4191162518892 bayes_pls_golite062009
sequence-specific DNA binding 2.23378431307469 bayes_pls_golite062009
transcription factor activity 1.63317649552979 bayes_pls_golite062009
structure-specific DNA binding 1.38449475025903 bayes_pls_golite062009
protein binding 0.961087148890615 bayes_pls_golite062009
transcription activator activity 0.774002575315721 bayes_pls_golite062009
transcription factor binding 0.68991166927379 bayes_pls_golite062009
DNA-dependent ATPase activity 0.683954534315832 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.52992575338445 bayes_pls_golite062009
double-stranded DNA binding 0.349632742873003 bayes_pls_golite062009
transcription repressor activity 0.140777233468428 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle