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View Structure Prediction Details

Protein: DLD1
Organism: Saccharomyces cerevisiae
Length: 587 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DLD1.

Description E-value Query
Range
Subject
Range
DLD1_YEAST - D-lactate dehydrogenase [cytochrome] 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 20450...
DLD1 - D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed ...
gi|151941831 - gi|151941831|gb|EDN60187.1| D-lactate ferricytochrome c oxidoreductase [Saccharomyces cerevisiae YJM...
gi|190405170 - gi|190405170|gb|EDV08437.1| D-lactate ferricytochrome c oxidoreductase [Saccharomyces cerevisiae RM1...
0.0 [1..587] [1..587]
DLD1_KLULA - D-lactate dehydrogenase [cytochrome], mitochondrial OS=Kluyveromyces lactis GN=DLD1 PE=3 SV=2
DLD1_KLULA - D-lactate dehydrogenase [cytochrome], mitochondrial OS=Kluyveromyces lactis (strain ATCC 8585 / CBS ...
0.0 [5..575] [13..567]
DLD_ARATH - D-lactate dehydrogenase [cytochrome], mitochondrial OS=Arabidopsis thaliana GN=DLD PE=1 SV=1
0.0 [49..577] [58..563]
gi|25323092 - pir||D97606 glycolate oxidase chain D-like, D-lactate dehydrogenase-like (AP002543) [imported] - Agr...
gi|15889339, gi|... - gi|15889339|ref|NP_355020.1| hypothetical protein AGR_C_3718 [Agrobacterium tumefaciens str. C58], g...
0.0 [88..576] [6..475]
gi|11279881 - pir||G81327 probable glycolate oxidase chain D Cj1213c [imported] - Campylobacter jejuni (strain NCT...
gi|112360531, gi... - gi|6968646|emb|CAB73467.1| putative glycolate oxidase subunit D [Campylobacter jejuni subsp. jejuni ...
gi|88596835, gi|... - gi|88596835|ref|ZP_01100072.1| glycolate oxidase, subunit GlcD [Campylobacter jejuni subsp. jejuni 8...
gi|86150362, gi|... - gi|86150362|ref|ZP_01068588.1| glycolate oxidase, subunit GlcD [Campylobacter jejuni subsp. jejuni C...
0.0 [107..574] [2..458]
gi|25323065 - pir||B83991 glycolate oxidase subunit BH2730 [imported] - Bacillus halodurans (strain C-125)
gi|10175351, gi|... - gi|15615293|ref|NP_243596.1| glycolate oxidase subunit [Bacillus halodurans C-125], gi|10175351|dbj|...
0.0 [112..581] [8..464]
gi|17429686 - gi|17429686|emb|CAD16371.1| putative d-lactate dehydrogenase (cytochrome) oxidoreductase protein [Ra...
gi|17547383 - gi|17547383|ref|NP_520785.1| putative D-lactate dehydrogenase (cytochrome) oxidoreductase protein [R...
0.0 [107..576] [16..471]
gi|221315135 - gi|221315135|ref|ZP_03596940.1| hypothetical protein BsubsN3_15562 [Bacillus subtilis subsp. subtili...
GLCD_BACSU - Glycolate oxidase subunit GlcD OS=Bacillus subtilis (strain 168) GN=glcD PE=3 SV=1
gi|221324335 - gi|221324335|ref|ZP_03605629.1| hypothetical protein BsubsS_15627 [Bacillus subtilis subsp. subtilis...
GLCD_BACSU - Glycolate oxidase subunit glcD OS=Bacillus subtilis GN=glcD PE=3 SV=1
gi|221320053 - gi|221320053|ref|ZP_03601347.1| hypothetical protein BsubsJ_15468 [Bacillus subtilis subsp. subtilis...
0.0 [107..581] [3..464]

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Predicted Domain #1
Region A:
Residues: [1-100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLWKRTCTRL IKPIAQPRGR LVRRSCYRYA STGTGSTDSS SQWLKYSVIA SSATLFGYLF  60
   61 AKNLYSRETK EDLIEKLEMV KKIDPVNSTL KLSSLDSPDY 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.682 a.47.2 t-snare proteins
View Download 0.635 a.7.8 GAT domain
View Download 0.628 a.126.1 Serum albumin-like
View Download 0.600 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.775 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.598 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.577 a.24.17 Group V grass pollen allergen
View Download 0.564 a.7.8 GAT domain
View Download 0.553 a.24.14 FAT domain of focal adhesion kinase
View Download 0.536 a.118.1 ARM repeat
View Download 0.535 a.24.3 Cytochromes
View Download 0.523 d.8.1 Urease, gamma-subunit
View Download 0.519 a.24.4 Hemerythrin
View Download 0.507 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.501 a.4.5 "Winged helix" DNA-binding domain
View Download 0.490 d.188.1 Prokaryotic ribosomal protein L17
View Download 0.480 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.422 a.74.1 Cyclin-like
View Download 0.421 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.417 a.118.1 ARM repeat
View Download 0.417 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.408 f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.398 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.397 a.61.1 Retroviral matrix proteins
View Download 0.377 a.24.9 alpha-catenin/vinculin
View Download 0.363 a.24.3 Cytochromes
View Download 0.362 a.29.2 Bromodomain
View Download 0.358 a.28.1 ACP-like
View Download 0.347 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.343 a.74.1 Cyclin-like
View Download 0.334 a.1.1 Globin-like
View Download 0.332 a.36.1 Signal peptide-binding domain
View Download 0.329 a.47.2 t-snare proteins
View Download 0.323 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.317 a.24.3 Cytochromes
View Download 0.316 a.7.8 GAT domain
View Download 0.316 a.7.8 GAT domain
View Download 0.300 a.22.1 Histone-fold
View Download 0.293 a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.292 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.292 a.47.2 t-snare proteins
View Download 0.291 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.277 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.277 a.7.7 BAG domain
View Download 0.274 d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.272 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.271 a.7.1 Spectrin repeat
View Download 0.262 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.258 i.11.1 Computational models partly based on NMR data
View Download 0.257 a.46.1 Methionine synthase domain
View Download 0.257 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.257 a.24.3 Cytochromes
View Download 0.254 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.253 d.82.2 Frataxin-like
View Download 0.252 a.134.1 Fungal elicitin
View Download 0.252 a.30.1 ROP protein
View Download 0.248 a.24.17 Group V grass pollen allergen
View Download 0.248 a.131.1 Peridinin-chlorophyll protein
View Download 0.247 a.24.9 alpha-catenin/vinculin
View Download 0.242 a.47.2 t-snare proteins
View Download 0.242 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.241 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.240 a.7.6 Ribosomal protein S20
View Download 0.237 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.237 a.1.1 Globin-like
View Download 0.235 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.233 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.232 d.50.3 PI-Pfui intein middle domain
View Download 0.231 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.231 a.1.1 Globin-like
View Download 0.230 a.1.1 Globin-like
View Download 0.230 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.229 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.229 i.1.1 Ribosome and ribosomal fragments
View Download 0.227 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.226 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.225 a.7.7 BAG domain
View Download 0.224 a.7.1 Spectrin repeat
View Download 0.224 a.7.8 GAT domain
View Download 0.224 a.22.1 Histone-fold
View Download 0.223 a.46.1 Methionine synthase domain
View Download 0.221 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.220 a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.220 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.217 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.214 a.61.1 Retroviral matrix proteins
View Download 0.213 a.23.2 Diol dehydratase, gamma subunit
View Download 0.210 a.2.3 Chaperone J-domain
View Download 0.209 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.209 a.6.1 Putative DNA-binding domain
View Download 0.208 a.47.2 t-snare proteins
View Download 0.207 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.203 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.203 a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.201 f.15.1 Small-conductance potassium channel
View Download 0.201 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.200 a.2.6 Effector domain of the protein kinase pkn/prk1

Predicted Domain #2
Region A:
Residues: [101-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHDPVKIDKV VEDLKQVLGN KPENYSDAKS DLDAHSDTYF NTHHPSPEQR PRIILFPHTT  60
   61 EEVSKILKIC HDNNMPVVPF SGGTSLEGHF LPTRIGDTIT VDLSKFMNNV VKFDKLDLDI 120
  121 TVQAGLPWED LNDYLSDHGL MFGCDPGPGA QIGGCIANSC SGTNAYRYGT MKENIINMTI 180
  181 VLPDGTIVKT KKRPRKSSAG YNLNGLFVGS EGTLGIVTEA TVKCHVK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [535-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVGIGKREYL LEELGEAPVD LMRKIKLAID PKRIMNPDKI FKTDPNEPAN DYR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 105.69897
Match: 1diiA_
Description: Flavoprotein subunit of p-cresol methylhydroxylase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [328-534]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKAETVAVVS FDTIKDAAAC ASNLTQSGIH LNAMELLDEN MMKLINASES TDRCDWVEKP  60
   61 TMFFKIGGRS PNIVNALVDE VKAVAQLNHC NSFQFAKDDD EKLELWEARK VALWSVLDAD 120
  121 KSKDKSAKIW TTDVAVPVSQ FDKVIHETKK DMQASKLINA IVGHAGDGNF HAFIVYRTPE 180
  181 EHETCSQLVD RMVKRALNAE GTCTGEH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 105.69897
Match: 1diiA_
Description: Flavoprotein subunit of p-cresol methylhydroxylase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle