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View Structure Prediction Details

Protein: TRP5
Organism: Saccharomyces cerevisiae
Length: 707 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRP5.

Description E-value Query
Range		 Subject
Range
TRP_YEAST - Tryptophan synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRP5 PE=1 SV=1
TRP5 - Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general co...
 0.0 [1..707] [1..707]
TRP_NEUCR - Tryptophan synthase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / F...
TRP_NEUCR - Tryptophan synthase OS=Neurospora crassa GN=trp-3 PE=1 SV=1
 0.0 [5..701] [4..708]
TRP_SCHPO - Tryptophan synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=trp2 PE=2 SV=1
trp2 - tryptophan synthase
 0.0 [1..701] [1..697]
gi|9651535 - gi|9651535|gb|AAF91181.1|AF207903_2 bifunctional tryptophan synthase TRPB [Emericella nidulans]
 0.0 [3..701] [2..723]
TRP_COPCI - Tryptophan synthase - Coprinus cinereus (Inky cap fungus) (Hormographiella aspergillata)
 0.0 [19..706] [15..701]
gi|107099030 - gi|107099030|ref|ZP_01362948.1| hypothetical protein PaerPA_01000038 [Pseudomonas aeruginosa PACS2]
TRPB_PSEAE - Tryptophan synthase beta chain OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / ...
TRPB_PSEAE - Tryptophan synthase beta chain OS=Pseudomonas aeruginosa GN=trpB PE=3 SV=2
gi|254237721, gi... - gi|84318276|ref|ZP_00966702.1| COG0133: Tryptophan synthase beta chain [Pseudomonas aeruginosa C3719...
gi|218888782, gi... - gi|218888782|ref|YP_002437646.1| tryptophan synthase subunit beta [Pseudomonas aeruginosa LESB58], g...
gi|194554133, gi... - gi|84324785|ref|ZP_00972840.1| COG0133: Tryptophan synthase beta chain [Pseudomonas aeruginosa 2192]...
 0.0 [295..691] [3..399]
TRBP2_ARATH - Tryptophan synthase beta chain 2, chloroplastic OS=Arabidopsis thaliana GN=TSB2 PE=1 SV=2
 0.0 [272..689] [55..474]
TRPB_PSESY - Tryptophan synthase beta chain OS=Pseudomonas syringae pv. syringae GN=trpB PE=3 SV=1
gi|476480, gi|151620 - pir||JQ2126 tryptophan synthase (EC 4.2.1.20) beta chain - Pseudomonas syringae, gi|151620|gb|AAA26...
 0.0 [296..689] [8..401]
gi|151616 - gi|151616|gb|AAA88462.1| tryptophan synthase beta subunit
 0.0 [295..691] [3..399]
TRPB_RHOS4 - Tryptophan synthase beta chain OS=Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / D...
gi|83365882, gi|... - gi|83373410|ref|ZP_00918189.1| Tryptophan synthase, beta chain [Rhodobacter sphaeroides ATCC 17029],...
TRPB_RHOSH - (Q9X4E5) Tryptophan synthase beta chain (EC 4.2.1.20)
 0.0 [288..689] [1..404]

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Predicted Domain #1
Region A:
Residues: [1-280] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEQLRQTFA NAKKENRNAL VTFMTAGYPT VKDTVPILKG FQDGGVDIIE LGMPFSDPIA  60
   61 DGPTIQLSNT VALQNGVTLP QTLEMVSQAR NEGVTVPIIL MGYYNPILNY GEERFIQDAA 120
  121 KAGANGFIIV DLPPEEALKV RNYINDNGLS LIPLVAPSTT DERLELLSHI ADSFVYVVSR 180
  181 MGTTGVQSSV ASDLDELISR VRKYTKDTPL AVGFGVSTRE HFQSVGSVAD GVVIGSKIVT 240
  241 LCGDAPEGKR YDVAKEYVQG ILNGAKHKVL SKDEFFAFQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 467.450636
Match: 1geqA_
Description: Trp synthase alpha-subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [281-350] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESLKSANVKK EILDEFDENH KHPIRFGDFG GQYVPEALHA CLRELEKGFD EAVADPTFWE  60
   61 DFKSLYSYIG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [384-501] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KINNALAQVL LAKRLGKKNV IAETGAGQHG VATATACAKF GLTCTVFMGA EDVRRQALNV  60
   61 FRMRILGAKV IAVTNGTKTL RDATSEAFRF WVTNLKTTYY VVGSAIGPHP YPTLVRTF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1276.0
Match: 1a5aB_
Description: Tryptophan synthase, beta-subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
tryptophan synthase activity 3.62092042588636 bayes_pls_golite062009
catalytic activity 2.38994231321972 bayes_pls_golite062009
lyase activity 1.87743897464083 bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates 1.42195744285403 bayes_pls_golite062009
binding 1.34539784687114 bayes_pls_golite062009
cysteine synthase activity 1.31641967296632 bayes_pls_golite062009
carbon-oxygen lyase activity 0.923824749425553 bayes_pls_golite062009
threonine synthase activity 0.727838845253199 bayes_pls_golite062009
ammonia-lyase activity 0.476674617721478 bayes_pls_golite062009
L-threonine ammonia-lyase activity 0.37325071016009 bayes_pls_golite062009
carbon-nitrogen lyase activity 0.249761226675912 bayes_pls_golite062009
protein binding 0.044015703839169 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [351-383] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPSSLHKAER LTEHCQGAQI WLKREDLNHT GSH

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [502-707] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSVIGKETKE QFAAMNNGKL PDAVVACVGG GSNSTGMFSP FEHDTSVKLL GVEAGGDGVD  60
   61 TKFHSATLTA GRPGVFHGVK TYVLQDSDGQ VHDTHSVSAG LDYPGVGPEL AYWKSTGRAQ 120
  121 FIAATDAQAL LGFKLLSQLE GIIPALESSH AVYGACELAK TMKPDQHLVI NISGRGDKDV 180
  181 QSVAEVLPKL GPKIGWDLRF EEDPSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1276.0
Match: 1a5aB_
Description: Tryptophan synthase, beta-subunit
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle