YRC Public Data Repository - Protein Structure Prediction

Protein:	GTO1
Organism:	Saccharomyces cerevisiae
Length:	356 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GTO1.

Description	E-value	Query Range	Subject Range
GTO2_YEAST - Glutathione S-transferase omega-like 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=E... gi\|151941615 - gi\|151941615\|gb\|EDN59978.1\| conserved protein [Saccharomyces cerevisiae YJM789] ECM4 - Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (... gi\|190409888 - gi\|190409888\|gb\|EDV13153.1\| extracellular matrix protein 4 [Saccharomyces cerevisiae RM11-1a]	0.0	[3..356]	[18..370]
gi\|14030631, gi\|... - gi\|23308293\|gb\|AAN18116.1\| At5g45020/K21C13_21 [Arabidopsis thaliana], gi\|15241645\|ref\|NP_199315.1\| ...	0.0	[2..354]	[19..315]
gi\|7469828 - pir\|\|S76960 hypothetical protein - Synechocystis sp. (strain PCC 6803) gi\|1653962, gi\|1... - gi\|1653962\|dbj\|BAA18872.1\| slr0605 [Synechocystis sp. PCC 6803], gi\|16332332\|ref\|NP_443060.1\| hypoth...	1.0E-96	[3..354]	[28..317]
gi\|25346669 - pir\|\|AI3308 glutathione transferase (EC 2.5.1.18) [imported] - Brucella melitensis (strain 16M) gi\|17982364, gi\|... - gi\|17986738\|ref\|NP_539372.1\| glutathione S-transferase [Brucella melitensis 16M], gi\|17982364\|gb\|AAL...	2.0E-94	[4..354]	[29..317]
gi\|15966123 - gi\|15966123\|ref\|NP_386476.1\| hypothetical protein SMc02708 [Sinorhizobium meliloti 1021] gi\|15075393 - gi\|15075393\|emb\|CAC46949.1\| Conserved hypothetical protein [Sinorhizobium meliloti 1021]	3.0E-93	[3..353]	[28..321]
gi\|14023233, gi\|... - gi\|14023233\|dbj\|BAB49840.1\| mll2799 [Mesorhizobium loti MAFF303099], gi\|13472487\|ref\|NP_104054.1\| hy...	1.0E-92	[3..353]	[28..316]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-92	[83..354]	[1..270]

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Predicted Domain #1

Region A:
Residues: [1-100]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSYKGTIS KTHSVFKPEK GRYYIYGALG CPFTHRAILA RSLKKLEPVL GLVLSHWQLD  60
   61 SKGARFLPAP HRPEKYKERF FTATGGIASA KLDESEELGD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.09691
Match:	1eemA_
Description:	Class omega GST
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutathione binding	2.07086805531749	bayes_pls_golite062009
glutathione transferase activity	1.85683051472829	bayes_pls_golite062009
antioxidant activity	1.78836688224506	bayes_pls_golite062009
peroxidase activity	1.62851025934188	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	1.62851025934188	bayes_pls_golite062009
binding	1.1101496519064	bayes_pls_golite062009
glutathione peroxidase activity	1.08052084417939	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.0279404567142	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
peroxiredoxin activity	0.366096607480921	bayes_pls_golite062009
protein binding	0.341730456502484	bayes_pls_golite062009
selenium binding	0.237008126838281	bayes_pls_golite062009
thioredoxin peroxidase activity	0.163136748643487	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [101-203]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNNDSARLFV DGAFDPVENI SRLSELYYLN DPKYPGTKFT VPVLWDSKTR KIVNNESGDI  60
   61 IRILNSGVFD EFIQSEETNV IDLVPHDLID EIDKNIKWVH PKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.09691
Match:	1eemA_
Description:	Class omega GST
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutathione transferase activity	3.95712498751783	bayes_pls_golite062009
glutathione binding	3.1027755387739	bayes_pls_golite062009
binding	1.73671487004343	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.08486797497934	bayes_pls_golite062009
transferase activity	1.05573069897577	bayes_pls_golite062009
catalytic activity	0.963623964325467	bayes_pls_golite062009
protein binding	0.816387415768278	bayes_pls_golite062009
glutathione peroxidase activity	0.0539815835450801	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [204-356]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLGVYKVGLA ENGKIYETEV KTLFENLQKM ECVLKENYKR LEEQFSGNKQ KILAKYFVLG  60
   61 QRLTEADIRL YPSIIRFDVV YVQHFKCNLK TIRDGFPYLH LWLINLYWNY AEFRFTTDFN 120
  121 HIKLFYIRME VSRNKINQFG IVPLGPKPDI SRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.221849
Match:	1k0mA_
Description:	Chloride intracellular channel 1 (clic1)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: