YRC Public Data Repository - Protein Structure Prediction

Protein:	MEF2
Organism:	Saccharomyces cerevisiae
Length:	819 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MEF2.

Description	E-value	Query Range	Subject Range
gi\|15028587 - gi\|15028587\|gb\|AAK77225.1\| elongation factor 2 [Aedes aegypti]	0.0	[23..792]	[1..839]
Ef2b-PC, Ef2b-PA... - The gene Elongation factor 2b is referred to in FlyBase by the symbol Dmel\Ef2b (CG2238, FBgn0000559... gi\|220948442 - gi\|220948442\|gb\|ACL86764.1\| Ef2b-PA [synthetic construct]	0.0	[23..792]	[1..839]
gi\|10279668 - gi\|10279668\|emb\|CAC09927.1\| translation elongation factor G, EF-G [Geobacillus stearothermophilus]	0.0	[38..774]	[7..688]
EFG_BACHD - Elongation factor G OS=Bacillus halodurans GN=fusA PE=3 SV=2 EFG_BACHD - Elongation factor G OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 /...	0.0	[38..774]	[7..688]
EFG_CAMJE - Elongation factor G OS=Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11... EFG_CAMJE - Elongation factor G OS=Campylobacter jejuni GN=fusA PE=3 SV=1 gi\|57504744, gi\|... - gi\|57504744\|ref\|ZP_00370798.1\| translation elongation factor G [Campylobacter coli RM2228], gi\|57019... EFG_CAMJ8 - Elongation factor G OS=Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828) G... gi\|88597042, gi\|... - gi\|88597042\|ref\|ZP_01100278.1\| translation elongation factor G [Campylobacter jejuni subsp. jejuni 8... gi\|86153594, gi\|... - gi\|86153594\|ref\|ZP_01071797.1\| translation elongation factor G [Campylobacter jejuni subsp. jejuni H... gi\|86149091, gi\|... - gi\|86149091\|ref\|ZP_01067323.1\| translation elongation factor G [Campylobacter jejuni subsp. jejuni C... EFG_CAMJR - Elongation factor G OS=Campylobacter jejuni (strain RM1221) GN=fusA PE=3 SV=1	0.0	[36..774]	[5..688]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[38..774]	[7..688]
EFG_HELPJ - Elongation factor G OS=Helicobacter pylori (strain J99 / ATCC 700824) GN=fusA PE=3 SV=3 gi\|7443440 - pir\|\|G71847 translation elongation factor EF-G (ef-g) - Helicobacter pylori (strain J99)	0.0	[35..782]	[4..692]

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Predicted Domain #1

Region A:
Residues: [1-330]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWKWNVRRWA GARVNISKNR LSVINVGSRY LSTARSPLSK VRNIGIIAHI DAGKTTTTER  60
   61 MLYYAGISKH IGDVDTGDTI TDFLEQERSR GITIQSAAIS FPWRNTFAIN LIDTPGHIDF 120
  121 TFEVIRALKV IDSCVVILDA VAGVEAQTEK VWKQSKSKPK ICFINKMDRM GASFNHTVND 180
  181 LINKFMRGTT TKPVLVNIPY YRKQPTSNDY VFQGVIDVVN GKRLTWNPEN PDEIIVDELD 240
  241 GTSLEQCNRC RESMIETLTE YDEDLVQHFL EEAEGDYSKV SAQFLNASIR KLTMKNMIVP 300
  301 VLCGASFKNI GVQPLLDAIV NYLPSPIEAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2060.0
Match:	1dar__
Description:	Elongation factor G (EF-G), domain II; Elongation factor G (EF-G), N-terminal (G) domain; Elongation factor G (EF-G), domain IV; Elongation factor G (EF-G)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of ribosome	2.31269308415192	bayes_pls_golite062009
structural molecule activity	1.96296069933386	bayes_pls_golite062009
translation elongation factor activity	1.78840251801545	bayes_pls_golite062009
translation release factor activity	1.47279606301067	bayes_pls_golite062009
translation termination factor activity	1.47162484856171	bayes_pls_golite062009
catalytic activity	0.878454819018611	bayes_pls_golite062009
binding	0.872512498570204	bayes_pls_golite062009
nucleic acid binding	0.555181608481691	bayes_pls_golite062009
transcription regulator activity	0.368412900600617	bayes_pls_golite062009
protein binding	0.0913090112555771	bayes_pls_golite062009
DNA binding	0.0880977286684361	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	6.9430052008157E-5	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [331-501]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPELNDKTVP MKYDPKVGCL VNNNKNLCIA LAFKVITDPI RGKQIFIRIY SGTLNSGNTV  60
   61 YNSTTGEKFK LGKLLIPHAG TSQPVNILTA GQIGLLTGST VENNISTGDT LITHSSKKDG 120
  121 LKSLDKKKEL TLKINSIFIP PPVFGVSIEP RTLSNKKSME EALNTLITED P

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2060.0
Match:	1dar__
Description:	Elongation factor G (EF-G), domain II; Elongation factor G (EF-G), N-terminal (G) domain; Elongation factor G (EF-G), domain IV; Elongation factor G (EF-G)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [502-774]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLSISQNDET GQTVLNGMGE LHLEIAKDRL VNDLKADVEF GQLMVSYKET INSETNIETY  60
   61 ESDDGYRFSL SLLPNSDALP NCLAYPLGVN ENFLIMEKNG NWDKEWKYQV SFESILNSII 120
  121 ASCIVGLQRG GKIANFPLYA CSIKINSDWS VPPDIETPQE ILKITRNLIF KALNDLKPEK 180
  181 YNLLEPIMNL DLTIPQSDVG TVLQDLTGAR KAQILSIEDE SSVSNSGAST CNSPENSNRI 240
  241 YIPSDAVTTL HATKDKKNTQ ETSSNVKKII KAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2060.0
Match:	1dar__
Description:	Elongation factor G (EF-G), domain II; Elongation factor G (EF-G), N-terminal (G) domain; Elongation factor G (EF-G), domain IV; Elongation factor G (EF-G)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [775-819]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPLREITTYT NKLRSLSQGR GEFNIEYSDM EKVTNDRLQS ILHDL

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.33
Match:	1efgA
Description:	Elongation factor G (EF-G), domain II; Elongation factor G (EF-G), N-terminal (G) domain; Elongation factor G (EF-G), domain IV; Elongation factor G (EF-G)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: