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View Structure Prediction Details

Protein: YKL222C
Organism: Saccharomyces cerevisiae
Length: 705 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YKL222C.

Description E-value Query
Range
Subject
Range
YKW2_YEAST - Uncharacterized transcriptional regulatory protein YKL222C OS=Saccharomyces cerevisiae (strain ATCC ...
YKL222C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; ...
gi|190409625 - gi|190409625|gb|EDV12890.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
0.0 [1..705] [1..705]
gi|2262187 - gi|2262187|gb|AAB63563.1| FacB [Aspergillus niger]
5.0E-77 [1..480] [1..490]
gi|2262191 - gi|2262191|gb|AAB63565.1| acetate regulatory DNA binding protein FacB [Emericella nidulans]
gi|67516815, gi|... - gi|67516815|ref|XP_658293.1| hypothetical protein AN0689.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
7.0E-75 [1..480] [1..492]
ACU15_NEUCR - Transcriptional activator protein acu-15 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS ...
ACU15_NEUCR, AC1... - Transcriptional activator protein acu-15 OS=Neurospora crassa GN=acu-15 PE=1 SV=2, (P87000) Transcri...
9.0E-74 [1..480] [1..493]
gi|2262189 - gi|2262189|gb|AAB63564.1| FacB [Aspergillus oryzae]
5.0E-72 [1..480] [1..487]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-69 [5..563] [20..603]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNTELSQKK KLDRQSRRKP AKSCHFCRVR KLKCDRVRPF CGSCSSRNRK QCEYKENTSA  60
   61 MEDQLRKKYR RCSKLEMARR IEELESQLTK QSQPN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.94696
Match: 1hwtD_
Description: Hap1 (Cyp1); HAP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
sequence-specific DNA binding 2.98081393153291 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.93914501897006 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.44382866473054 bayes_pls_golite062009
transcription activator activity 2.24483536326713 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [96-208]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IHEGQNPLSN MRYLSSKHNR HILYGPTSYR AILATQTDTF AKYREEIWQV LKLSRNNWKR  60
   61 EHHYSTLSEI SSIETAPPHS GSPSVIEYLC ESLPNYEVLC EYLTDFFASD FYD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.677 a.1.1 Globin-like
View Download 0.639 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.537 a.118.8 TPR-like
View Download 0.530 a.118.1 ARM repeat
View Download 0.491 a.26.1 4-helical cytokines
View Download 0.478 a.1.1 Globin-like
View Download 0.426 a.1.1 Globin-like
View Download 0.380 d.168.1 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
View Download 0.377 a.7.1 Spectrin repeat
View Download 0.377 a.24.15 FAD-dependent thiol oxidase
View Download 0.377 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.349 a.59.1 PAH2 domain
View Download 0.347 d.110.4 SNARE-like
View Download 0.346 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.343 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.330 d.92.2 beta-N-acetylhexosaminidase-like domain
View Download 0.326 a.26.1 4-helical cytokines
View Download 0.320 d.54.1 Enolase N-terminal domain-like
View Download 0.317 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.283 d.54.1 Enolase N-terminal domain-like
View Download 0.281 a.22.1 Histone-fold
View Download 0.263 c.55.3 Ribonuclease H-like
View Download 0.262 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.259 a.185.1 Gametocyte protein Pfg27
View Download 0.259 c.55.6 DNA repair protein MutS, domain II
View Download 0.254 c.47.1 Thioredoxin-like
View Download 0.245 c.55.3 Ribonuclease H-like
View Download 0.243 b.55.1 PH domain-like
View Download 0.242 a.130.1 Chorismate mutase II
View Download 0.241 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.240 a.29.2 Bromodomain
View Download 0.239 a.1.1 Globin-like
View Download 0.235 a.24.17 Group V grass pollen allergen
View Download 0.232 a.118.9 ENTH/VHS domain
View Download 0.230 a.118.1 ARM repeat
View Download 0.216 d.58.16 Poly(A) polymerase, C-terminal domain
View Download 0.208 d.227.1 OsmC-like
View Download 0.200 d.228.1 Replication modulator SeqA, C-terminal DNA-binding domain

Predicted Domain #3
Region A:
Residues: [209-452]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYQIVHKEKV LRDLQDCFVK GPRSHKTGQH TIISLNLDSK KNYYKVGVMT AIMCLASHPK  60
   61 EVPEAIEVFH KVLTSFVSAK VFYTERVQFL FLRYLYINVA GLDGGDQSHC IFIHGLTIDT 120
  121 AIHMGLNEDL RRLYLSKNHP IEEIPYLERL WLWILFTDVK ISLSTGIPVR INDDFVNKVR 180
  181 LENYSSSGDI LLYKTTLRLR NIMKQIHARE KPPDIPLIIE DLKKFTIKMF KPLDFYLNAS 240
  241 NLNG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [453-518]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEFTELQLWH ATLHMIGSLS NLYTLTHQDF DARIFNFSVL APLNSLHLCF NVLETYFELD  60
   61 NSKLSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.685 a.4.1 Homeodomain-like
View Download 0.685 a.4.1 Homeodomain-like
View Download 0.665 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.665 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.661 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.661 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.658 a.51.1 Cytochrome c oxidase subunit h
View Download 0.658 a.51.1 Cytochrome c oxidase subunit h
View Download 0.645 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.645 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.640 a.118.1 ARM repeat
View Download 0.605 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.592 a.4.1 Homeodomain-like
View Download 0.563 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.560 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.553 a.39.1 EF-hand
View Download 0.550 a.5.2 UBA-like
View Download 0.545 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.533 a.4.5 "Winged helix" DNA-binding domain
View Download 0.523 a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.523 a.4.5 "Winged helix" DNA-binding domain
View Download 0.518 a.77.1 DEATH domain
View Download 0.512 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.499 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.487 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.474 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.467 a.144.1 PABC (PABP) domain
View Download 0.456 a.4.5 "Winged helix" DNA-binding domain
View Download 0.440 a.50.1 Anaphylotoxins (complement system)
View Download 0.436 a.16.1 S15/NS1 RNA-binding domain
View Download 0.429 a.144.2 Ribosomal protein L20
View Download 0.427 a.4.1 Homeodomain-like
View Download 0.420 a.156.1 S13-like H2TH domain
View Download 0.411 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.407 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.399 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.394 d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.386 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.384 a.4.5 "Winged helix" DNA-binding domain
View Download 0.379 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.377 a.4.5 "Winged helix" DNA-binding domain
View Download 0.375 a.38.1 Helix-loop-helix DNA-binding domain
View Download 0.370 a.4.5 "Winged helix" DNA-binding domain
View Download 0.359 a.2.3 Chaperone J-domain
View Download 0.354 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.349 a.112.1 Description not found.
View Download 0.348 d.58.17 Metal-binding domain
View Download 0.347 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.336 a.156.1 S13-like H2TH domain
View Download 0.336 a.64.1 Saposin
View Download 0.325 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.322 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.320 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.319 a.60.11 Hypothetical protein YjbJ
View Download 0.303 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.303 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.302 d.58.25 Killer toxin KP6 alpha-subunit
View Download 0.300 a.112.1 Description not found.
View Download 0.299 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.299 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.290 a.7.6 Ribosomal protein S20
View Download 0.287 a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.283 c.47.1 Thioredoxin-like
View Download 0.283 a.20.1 PGBD-like
View Download 0.282 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.281 a.5.6 Hypothetical protein MTH1615
View Download 0.281 a.39.1 EF-hand
View Download 0.279 a.21.1 HMG-box
View Download 0.278 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.277 a.39.4 Hypothetical protein MTH865
View Download 0.275 a.39.1 EF-hand
View Download 0.274 a.156.1 S13-like H2TH domain
View Download 0.266 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.263 a.64.1 Saposin
View Download 0.263 d.48.1 RecA protein, C-terminal domain
View Download 0.262 a.55.1 IHF-like DNA-binding proteins
View Download 0.257 a.46.1 Methionine synthase domain
View Download 0.255 g.57.1 Serine proteinase inhibitor lekti
View Download 0.245 a.59.1 PAH2 domain
View Download 0.245 a.3.1 Cytochrome c
View Download 0.238 f.15.1 Small-conductance potassium channel
View Download 0.238 d.186.1 Head-to-tail joining protein W, gpW
View Download 0.234 d.15.2 CAD & PB1 domains
View Download 0.230 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.223 d.102.1 Regulatory factor Nef
View Download 0.222 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.216 a.5.2 UBA-like
View Download 0.212 f.17.1 F1F0 ATP synthase subunit C
View Download 0.210 d.54.1 Enolase N-terminal domain-like
View Download 0.209 a.24.17 Group V grass pollen allergen
View Download 0.209 a.5.2 UBA-like
View Download 0.203 a.3.1 Cytochrome c
View Download 0.202 a.28.3 Retrovirus capsid protein C-terminal domain

Predicted Domain #5
Region A:
Residues: [519-705]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSLCLSKKWP HLNNALFLIY VNAFRALIQI YTIFLQYMEN KDIQLFIQRN SSALTYSICP  60
   61 GDFEGPHNKC ISLKIAFKEM ENIFDHIHQE KLKPLTQIWQ NSYYFSIIIS MEKIGRRAFN 120
  121 KGMKNIDEGP ETENDATENS LTTILNDLEG PLEDFSENFI DDILGSPSAF FDTAISGWSN 180
  181 FEDFFSR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle