YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: DNM1
Organism: Saccharomyces cerevisiae
Length: 757 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DNM1.

Description E-value Query
Range		 Subject
Range
DYN1_MOUSE - Dynamin-1 OS=Mus musculus GN=Dnm1 PE=1 SV=2
 0.0 [4..756] [6..741]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [4..756] [6..745]
gi|207343221 - gi|207343221|gb|EDZ70749.1| YLL001Wp-like protein [Saccharomyces cerevisiae AWRI1631]
DNM1 - Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasm...
gi|151941168 - gi|151941168|gb|EDN59546.1| dynamin-related protein [Saccharomyces cerevisiae YJM789]
DNM1_YEAST - Dynamin-related protein DNM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DNM1 PE=1 S...
 0.0 [1..757] [1..757]
gi|123230379 - gi|123230379|emb|CAM15857.1| dynamin 1 [Mus musculus]
DYN1_RAT - Dynamin-1 - Rattus norvegicus (Rat)
 0.0 [4..756] [6..745]
gi|12052944 - gi|12052944|emb|CAB66647.1| hypothetical protein [Homo sapiens]
gi|117646508, gi... - gi|117646508|emb|CAL38721.1| hypothetical protein [synthetic construct], gi|117646152|emb|CAL38543.1...
HGNC:29125|MIM:6... - 3
 0.0 [4..756] [6..739]

Back

Predicted Domain #1
Region A:
Residues: [1-353] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASLEDLIPT VNKLQDVMYD SGIDTLDLPI LAVVGSQSSG KSSILETLVG RDFLPRGTGI  60
   61 VTRRPLVLQL NNISPNSPLI EEDDNSVNPH DEVTKISGFE AGTKPLEYRG KERNHADEWG 120
  121 EFLHIPGKRF YDFDDIKREI ENETARIAGK DKGISKIPIN LKVFSPHVLN LTLVDLPGIT 180
  181 KVPIGEQPPD IEKQIKNLIL DYIATPNCLI LAVSPANVDL VNSESLKLAR EVDPQGKRTI 240
  241 GVITKLDLMD SGTNALDILS GKMYPLKLGF VGVVNRSQQD IQLNKTVEES LDKEEDYFRK 300
  301 HPVYRTISTK CGTRYLAKLL NQTLLSHIRD KLPDIKTKLN TLISQTEQEL ARY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1175.0
Match: 1jwyB_
Description: Dynamin G domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 6.13591371239337 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
plus-end-directed microtubule motor activity 2.65631438185675 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
microfilament motor activity 2.51786963027655 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
primary active transmembrane transporter activity 2.39629638016861 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.39600931083427 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.36051733655256 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.35906629925754 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.35679406876731 bayes_pls_golite062009
actin binding 2.2973522188675 bayes_pls_golite062009
ATPase activity, coupled 2.24901251684901 bayes_pls_golite062009
binding 2.21604035604783 bayes_pls_golite062009
substrate-specific transporter activity 1.65609907941094 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.3182108176243 bayes_pls_golite062009
actin filament binding 1.28204719195916 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
actin-dependent ATPase activity 0.92105578610354 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
ion transmembrane transporter activity 0.704934361725919 bayes_pls_golite062009
molecular transducer activity 0.501012663775049 bayes_pls_golite062009
signal transducer activity 0.501012663775049 bayes_pls_golite062009
protein transporter activity 0.498432226280822 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
signal recognition particle binding 0.29390189699022 bayes_pls_golite062009
cation transmembrane transporter activity 0.282397764628576 bayes_pls_golite062009
glutamate receptor binding 0.24961792304497 bayes_pls_golite062009
nucleic acid binding 0.194779852865789 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
minus-end-directed microtubule motor activity 0.068779631341469 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [354-543] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGVGATTNES RASLVLQLMN KFSTNFISSI DGTSSDINTK ELCGGARIYY IYNNVFGNSL  60
   61 KSIDPTSNLS VLDVRTAIRN STGPRPTLFV PELAFDLLVK PQIKLLLEPS QRCVELVYEE 120
  121 LMKICHKCGS AELARYPKLK SMLIEVISEL LRERLQPTRS YVESLIDIHR AYINTNHPNF 180
  181 LSATEAMDDI

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 50.318759
Match: PF01031
Description: Dynamin central region

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [544-660] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTRRKRNQE LLKSKLSQQE NGQTNGINGT SSISSNIDQD SAKNSDYDDD GIDAESKQTK  60
   61 DKFLNYFFGK DKKGQPVFDA SDKKRSIAGD GNIEDFRNLQ ISDFSLGDID DLENAEP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.39794
Match: 1dynA_
Description: Dynamin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.72754591832642 bayes_pls_golite062009
cytoskeletal protein binding 3.48744511411671 bayes_pls_golite062009
binding 2.86147407357315 bayes_pls_golite062009
protein binding 2.12168271674167 bayes_pls_golite062009
actin filament binding 2.03444575838575 bayes_pls_golite062009
signal transducer activity 1.37089850538776 bayes_pls_golite062009
molecular transducer activity 1.37089850538776 bayes_pls_golite062009
glutamate receptor binding 1.33361798466456 bayes_pls_golite062009
transporter activity 1.28986800087234 bayes_pls_golite062009
phospholipid binding 1.09683218092034 bayes_pls_golite062009
protein domain specific binding 0.90578029954417 bayes_pls_golite062009
phosphoinositide binding 0.71817045430443 bayes_pls_golite062009
substrate-specific transporter activity 0.54401901869178 bayes_pls_golite062009
receptor binding 0.50127063593663 bayes_pls_golite062009
structural constituent of cytoskeleton 0.35466574267734 bayes_pls_golite062009
phosphoinositide 3-kinase binding 0.35270637154617 bayes_pls_golite062009
receptor activity 0.249700281733733 bayes_pls_golite062009
profilin binding 0.21255426011209 bayes_pls_golite062009
clathrin binding 0.200189120318518 bayes_pls_golite062009
alpha-catenin binding 0.102004310679969 bayes_pls_golite062009
transmembrane receptor activity 0.0950861172257715 bayes_pls_golite062009
pyrophosphatase activity 0.0611639610381174 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0524559849408587 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0498422520006935 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.0453434814121247 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [661-757] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLTEREELEC ELIKRLIVSY FDIIREMIED QVPKAVMCLL VNYCKDSVQN RLVTKLYKET  60
   61 LFEELLVEDQ TLAQDRELCV KSLGVYKKAA TLISNIL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 42.552842
Match: PF02212
Description: Dynamin GTPase effector domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.917 0.057 mitochondrion inheritance a.7.1 Spectrin repeat
View Download 0.962 0.034 mitochondrion inheritance a.2.7 tRNA-binding arm
View Download 0.945 0.008 mitochondrion inheritance f.17.1 F1F0 ATP synthase subunit C
View Download 0.934 0.008 mitochondrion inheritance a.24.1 Apolipoprotein
View Download 0.922 N/A N/A a.24.1 Apolipoprotein

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle