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View Structure Prediction Details

Protein: YPS3
Organism: Saccharomyces cerevisiae
Length: 508 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPS3.

Description E-value Query
Range
Subject
Range
YPS3 - Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YPS3_YEAST - Aspartic proteinase yapsin-3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPS3 PE=1 S...
gi|151941286 - gi|151941286|gb|EDN59664.1| aspartic protease [Saccharomyces cerevisiae YJM789]
0.0 [1..508] [1..508]
gi|6180007 - gi|6180007|gb|AAF05750.1|AF191336_1 pregnancy-associated glycoprotein-11 [Capra hircus]
0.0 [1..396] [1..379]
PAG1_BOVIN - Pregnancy-associated glycoprotein 1 OS=Bos taurus PE=1 SV=1
0.0 [1..396] [1..379]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLQLAAVAT LAVLTSPAFG RVLPDGKYVK IPFTKKKNGD NGELSKRSNG HEKFVLANEQ  60
   61 SFYS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [208-244]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DATAYSLFLN DESQSSGSIL FGAVDHSKYE GQLYTIP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [379-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAYVVYDLDN YEISLAQAKY GTGKENVEVI KSTVPSAIRA PSYNNTWSNY ASATS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 918.68867
Match: 1ypsA_
Description: No description for 1ypsA_ was found.

Predicted functions:

Term Confidence Notes
aspartic-type endopeptidase activity 7.9145950161796 bayes_pls_golite062009
aspartic-type peptidase activity 7.9145950161796 bayes_pls_golite062009
peptidase activity 5.78181196721293 bayes_pls_golite062009
endopeptidase activity 5.4888481808613 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 5.39972232367526 bayes_pls_golite062009
hydrolase activity 4.34796304893506 bayes_pls_golite062009
catalytic activity 1.54514410489082 bayes_pls_golite062009
binding 1.10054369202721 bayes_pls_golite062009
receptor binding 0.561225023505917 bayes_pls_golite062009
protein binding 0.193907750061394 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [65-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VELAIGTPSQ NLTVLLDTGS ADLWVPGKGN PYCGSVMDCD QYGVFDKTKS STFKANKSSP  60
   61 FYAAYGDGTY AEGAFGQDKL KYNELDLSGL SFAVANESNS TFGVLGIGLS TLEVTYSGKV 120
  121 AIMDKRSYEY DNFPLFLKHS GAI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [245-378]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVNLYKSQGY QHPVAFDVTL QGLGLQTDKR NITLTTTKLP ALLDSGTTLT YLPSQAVALL  60
   61 AKSLNASYSK TLGYYEYTCP SSDNKTSVAF DFGGFRINAP LSDFTMQTSV GTCVLAIIPQ 120
  121 AGNATAILGD SFLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 918.68867
Match: 1ypsA_
Description: No description for 1ypsA_ was found.

Predicted Domain #3
Region A:
Residues: [434-508]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGNIFTTVRT FNGTSTATTT RSTTTKKTNS TTTAKSTHKS KRALQRAATN SASSIRSTLG  60
   61 LLLVPSLLIL SVFFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.537 a.133.1 Phospholipase A2, PLA2
View Download 0.580 a.22.1 Histone-fold
View Download 0.593 d.64.1 eIF1-like
View Download 0.687 a.46.1 Methionine synthase domain
View Download 0.489 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.468 a.105.1 FIS-like
View Download 0.457 a.29.4 RecG, N-terminal domain
View Download 0.449 a.112.1 Description not found.
View Download 0.434 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.401 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.386 a.29.4 RecG, N-terminal domain
View Download 0.378 d.52.7 Ribosome-binding factor A, RbfA
View Download 0.378 a.2.3 Chaperone J-domain
View Download 0.356 a.64.1 Saposin
View Download 0.336 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.333 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.329 b.84.2 Rudiment single hybrid motif
View Download 0.322 d.141.1 Ribosomal protein L6
View Download 0.321 a.46.1 Methionine synthase domain
View Download 0.320 f.17.1 F1F0 ATP synthase subunit C
View Download 0.317 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.316 b.84.2 Rudiment single hybrid motif
View Download 0.312 a.22.1 Histone-fold
View Download 0.307 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.303 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.301 b.1.2 Fibronectin type III
View Download 0.299 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.297 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.290 a.7.6 Ribosomal protein S20
View Download 0.287 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.284 a.46.1 Methionine synthase domain
View Download 0.278 c.55.4 Translational machinery components
View Download 0.278 f.13.1 Family A G protein-coupled receptor-like
View Download 0.270 f.13.1 Family A G protein-coupled receptor-like
View Download 0.268 a.7.6 Ribosomal protein S20
View Download 0.258 c.55.4 Translational machinery components
View Download 0.258 a.7.6 Ribosomal protein S20
View Download 0.251 a.77.1 DEATH domain
View Download 0.246 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.246 a.29.4 RecG, N-terminal domain
View Download 0.243 d.58.12 eEF-1beta-like
View Download 0.238 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.233 a.22.1 Histone-fold
View Download 0.226 a.77.1 DEATH domain
View Download 0.225 a.77.1 DEATH domain
View Download 0.219 d.6.1 Prion-like
View Download 0.208 b.40.2 Bacterial enterotoxins
View Download 0.207 d.52.4 YhbC-like, N-terminal domain
View Download 0.207 d.109.1 Actin depolymerizing proteins
View Download 0.207 a.38.1 Helix-loop-helix DNA-binding domain
View Download 0.206 a.46.1 Methionine synthase domain
View Download 0.204 d.188.1 Prokaryotic ribosomal protein L17
View Download 0.200 a.85.1 Hemocyanin, N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle