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View Structure Prediction Details

Protein: MDL1
Organism: Saccharomyces cerevisiae
Length: 695 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDL1.

Description E-value Query
Range		 Subject
Range
MDR1_CRIGR - Multidrug resistance protein 1 OS=Cricetulus griseus GN=ABCB1 PE=1 SV=2
 0.0 [60..693] [6..644]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [60..693] [6..644]
gi|149029024, gi... - gi|7739773|gb|AAF69007.1|AF257746_1 multidrug resistance protein 1a [Rattus norvegicus], gi|62646634...
 0.0 [62..691] [8..637]
ABCB1 - ATP-binding cassette, sub-family B (MDR/TAP), member 1
gi|117645528 - gi|117645528|emb|CAL38230.1| hypothetical protein [synthetic construct]
 0.0 [59..693] [7..647]
gi|8926217 - gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance glycoprotein MDR1 [synthetic construct]
 0.0 [74..694] [27..656]
gi|57526446, gi|... - gi|57526446|ref|NP_001009790.1| ATP-binding cassette, subfamily B, member 1 [Ovis aries], gi|2149087...
 0.0 [67..690] [18..649]
MDR3_MOUSE - Multidrug resistance protein 3 OS=Mus musculus GN=Abcb1a PE=2 SV=2
 0.0 [62..693] [8..643]
gi|50978984, gi|... - gi|50978984|ref|NP_001003215.1| ATP-binding cassette, subfamily B, member 1 [Canis lupus familiaris]...
 0.0 [62..694] [8..649]

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Predicted Domain #1
Region A:
Residues: [1-78] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVRMIRLCK GPKLLRSQFA SASALYSTKS LFKPPMYQKA EINLIIPHRK HFLLRSIRLQ  60
   61 SDIAQGKKST KPTLKLSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [79-195] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANSKSSGFKD IKRLFVLSKP ESKYIGLALL LILISSSVSM AVPSVIGKLL DLASESDGED  60
   61 EEGSKSNKLY GFTKKQFFTA LGAVFIIGAV ANASRIIILK VTGERLVARL RTRTMKA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [214-411] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRLSSDASIV AKSVTQNVSD GTRAIIQGFV GFGMMSFLSW KLTCVMMILA PPLGAMALIY  60
   61 GRKIRNLSRQ LQTSVGGLTK VAEEQLNATR TIQAYGGEKN EVRRYAKEVR NVFHIGLKEA 120
  121 VTSGLFFGST GLVGNTAMLS LLLVGTSMIQ SGSMTVGELS SFMMYAVYTG SSLFGLSSFY 180
  181 SELMKGAGAA ARVFELND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 798.9794
Match: 1jsqA_
Description: MsbA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lipid transporter activity 7.47642599298853 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 5.57844095962502 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.57813579764186 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.57813579764186 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.5689620139321 bayes_pls_golite062009
primary active transmembrane transporter activity 5.55992639965745 bayes_pls_golite062009
active transmembrane transporter activity 5.50005167063544 bayes_pls_golite062009
ATPase activity, coupled 4.98276715440477 bayes_pls_golite062009
peptide transporter activity 4.7442815698413 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 4.71935767060308 bayes_pls_golite062009
ATPase activity 4.69795387297193 bayes_pls_golite062009
peptide-transporting ATPase activity 4.63590351019108 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.45923622153365 bayes_pls_golite062009
pyrophosphatase activity 4.39781350157199 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.38133275795019 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.38085303582726 bayes_pls_golite062009
oligopeptide-transporting ATPase activity 4.09365342567844 bayes_pls_golite062009
transporter activity 3.71239480053329 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity 3.20894563245332 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 3.16975154423199 bayes_pls_golite062009
hydrolase activity 3.14498892233323 bayes_pls_golite062009
transmembrane transporter activity 3.13960906549884 bayes_pls_golite062009
anion transmembrane transporter activity 3.13913638619234 bayes_pls_golite062009
substrate-specific transporter activity 3.1318898376276 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
ATP binding 3.01346604299372 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.00745742755195 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
adenyl ribonucleotide binding 2.96271391116269 bayes_pls_golite062009
adenyl nucleotide binding 2.91131545957759 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
purine ribonucleotide binding 2.70262534541085 bayes_pls_golite062009
ribonucleotide binding 2.70178191749524 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
purine nucleotide binding 2.6583477492092 bayes_pls_golite062009
nucleotide binding 2.62374702628143 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
sterol transporter activity 2.48473697371886 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
vitamin transporter activity 2.1653565229854 bayes_pls_golite062009
phosphate transmembrane transporter activity 2.15147988861177 bayes_pls_golite062009
oligopeptide transporter activity 2.05580564974083 bayes_pls_golite062009
L-aspartate transmembrane transporter activity 2.05274761921715 bayes_pls_golite062009
binding 1.84115074893083 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
organic anion transmembrane transporter activity 1.76999970080179 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
nucleic acid binding 1.52921795164482 bayes_pls_golite062009
phosphonate transmembrane transporter activity 1.40269234722336 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
molybdate ion transmembrane transporter activity 1.28313088935613 bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity 1.28313088935613 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
DNA binding 1.19966224604123 bayes_pls_golite062009
potassium channel activity 1.17288958041707 bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity 1.1220946941463 bayes_pls_golite062009
transcription regulator activity 1.09075553688438 bayes_pls_golite062009
dipeptide transporter activity 1.01130176523309 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
thiamin transmembrane transporter activity 0.933872128802939 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
structural constituent of ribosome 0.860102064846772 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
copper ion transmembrane transporter activity 0.798934081014025 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
cholesterol transporter activity 0.644421039250979 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 0.442220326523999 bayes_pls_golite062009
ligase activity 0.417681194526243 bayes_pls_golite062009
catalytic activity 0.368034275052766 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
signal transducer activity 0.286367085584159 bayes_pls_golite062009
molecular transducer activity 0.286367085584159 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
signal recognition particle binding 0.20866768220789 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
structural molecule activity 0.11239762372728 bayes_pls_golite062009
sulfate transmembrane transporter activity 0.104477131120205 bayes_pls_golite062009
transcription factor activity 0.0612932659603008 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [196-213] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALDQDATFLD TNRVGDLI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [412-695] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKPLIRPTIG KDPVSLAQKP IVFKNVSFTY PTRPKHQIFK DLNITIKPGE HVCAVGPSGS  60
   61 GKSTIASLLL RYYDVNSGSI EFGDEDIRNF NLRKYRRLIG YVQQEPLLFN GTILDNILYC 120
  121 IPPEIAEQDD RIRRAIGKAN CTKFLANFPD GLQTMVGARG AQLSGGQKQR IALARAFLLD 180
  181 PAVLILDEAT SALDSQSEEI VAKNLQRRVE RGFTTISIAH RLSTIKHSTR VIVLGKHGSV 240
  241 VETGSFRDLI AIPNSELNAL LAEQQDEEGK GGVIDLDNSV AREV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 798.9794
Match: 1jsqA_
Description: MsbA
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle