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View Structure Prediction Details

Protein: SEC12
Organism: Saccharomyces cerevisiae
Length: 471 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC12.

Description E-value Query
Range
Subject
Range
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
0.0 [6..466] [1069..1491]
gi|17225208 - gi|17225208|gb|AAL37300.1|AF323584_1 beta transducin-like protein HET-E2C*40 [Podospora anserina]
0.0 [6..465] [836..1257]

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Predicted Domain #1
Region A:
Residues: [1-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFVTASYNV GYPAYGAKFL NNDTLLVAGG GGEGNNGIPN KLTVLRVDPT KDTEKEQFHI  60
   61 LSEFALEDND DSPTAIDASK GIILVGCNEN STKITQGKGN KHLRKFKYDK VNDQLEFLTS 120
  121 VDFDASTNAD DYTKLVYISR EGTVAAIASS KVPAIMRIID PSDLTEKFEI ETRGEVKDLH 180
  181 FSTDGKVVAY ITGSSLEVIS TVTGSCIARK TDFDKNWSLS KINFIADDTV LIAASLKKGK 240
  241 GIVLTKISIK SGNTSVLRSK QVTNRFKGIT SMDVDMKGEL AVLASNDNSI ALVKLKDLSM 300
  301 SKIFKQAHSF AITEVTISPD STYVASVSAA NTIHIIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.154902
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.61720914342874 bayes_pls_golite062009
binding 1.40353148474598 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.949459052802047 bayes_pls_golite062009
small conjugating protein ligase activity 0.876326238093745 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
protein transporter activity 0.304681243699511 bayes_pls_golite062009
nucleic acid binding 0.110806113669931 bayes_pls_golite062009
acid-amino acid ligase activity 0.0294947647335083 bayes_pls_golite062009
hydrolase activity 0.0078918747815433 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [338-471]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPLNYANYTS MKQKISKFFT NFILIVLLSY ILQFSYKHNL HSMLFNYAKD NFLTKRDTIS  60
   61 SPYVVDEDLH QTTLFGNHGT KTSVPSVDSI KVHGVHETSS VNGTEVLCTE SNIINTGGAE 120
  121 FEITNATFRE IDDA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.30103
Match: 1gxrA_
Description: Groucho/tle1, C-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle