YRC Public Data Repository - Protein Structure Prediction

Protein:	MDH2
Organism:	Saccharomyces cerevisiae
Length:	423 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDH2.

Description	E-value	Query Range	Subject Range
gi\|151945509 - gi\|151945509\|gb\|EDN63750.1\| malate dehydrogenase [Saccharomyces cerevisiae YJM789] gi\|190407226 - gi\|190407226\|gb\|EDV10493.1\| malate dehydrogenase [Saccharomyces cerevisiae RM11-1a] MDH2 - Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and ...	0.0	[1..423]	[1..423]
gi\|17368677, gi\|... - gi\|17368677\|sp\|Q9BE24\|LDHA_MACFA L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M...	0.0	[40..415]	[2..332]
LDHA_PIG - L-lactate dehydrogenase A chain OS=Sus scrofa GN=LDHA PE=1 SV=3 gi\|473571 - gi\|473571\|gb\|AAA50436.1\| lactate dehydrogenase-A	0.0	[40..415]	[2..332]
LDHA - lactate dehydrogenase A	0.0	[40..415]	[1..331]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[40..415]	[1..331]
LDHA_BOVIN - L-lactate dehydrogenase A chain OS=Bos taurus GN=LDHA PE=2 SV=2	0.0	[40..415]	[2..332]
gi\|55249958 - gb\|AAH86251.1\| Unknown (protein for MGC:98768) [Xenopus laevis] LDHA_MOUSE - L-lactate dehydrogenase A chain OS=Mus musculus GN=Ldha PE=1 SV=3	0.0	[40..415]	[2..332]
LDHA_MONDO - L-lactate dehydrogenase A chain OS=Monodelphis domestica GN=LDHA PE=2 SV=3	0.0	[41..415]	[3..332]

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Predicted Domain #1

Region A:
Residues: [1-423]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILLLILFPC IYFLPFCINR TVRSSPEYSA ADYYKSSIQY HKSYSNMPHS VTPSIEQDSL  60
   61 KIAILGAAGG IGQSLSLLLK AQLQYQLKES NRSVTHIHLA LYDVNQEAIN GVTADLSHID 120
  121 TPISVSSHSP AGGIENCLHN ASIVVIPAGV PRKPGMTRDD LFNVNAGIIS QLGDSIAECC 180
  181 DLSKVFVLVI SNPVNSLVPV MVSNILKNHP QSRNSGIERR IMGVTKLDIV RASTFLREIN 240
  241 IESGLTPRVN SMPDVPVIGG HSGETIIPLF SQSNFLSRLN EDQLKYLIHR VQYGGDEVVK 300
  301 AKNGKGSATL SMAHAGYKCV VQFVSLLLGN IEQIHGTYYV PLKDANNFPI APGADQLLPL 360
  361 VDGADYFAIP LTITTKGVSY VDYDIVNRMN DMERNQMLPI CVSQLKKNID KGLEFVASRS 420
  421 ASS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	621.529817
Match:	1mldA_
Description:	Malate dehydrogenase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits