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View Structure Prediction Details

Protein: RUP1
Organism: Saccharomyces cerevisiae
Length: 671 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RUP1.

Description E-value Query
Range
Subject
Range
RUP1 - Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domai...
RUP1_YEAST - UBA domain-containing protein RUP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RUP1 ...
0.0 [1..652] [1..652]

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Predicted Domain #1
Region A:
Residues: [1-67]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMDNQAVKSL LEMGIPHEVA VDALQRTGGN LEAAVNFIFS NELPEQAEMG EENDGSQPRI  60
   61 SENKIVA

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 7.619789
Match: PF00627
Description: UBA/TS-N domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [68-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTKPCDVPNN GDQDIDMPDV SGVDVDYDDD EDITDERSGS NSTSGCRVTA QNYDRYSISE  60
   61 TSIPPPSYSI VQHNEFKSNV GDPTVVLPLP LNSLIESYFG LFALLTAVYF PHVFLKPDFK 120
  121 DLNYRADWFK GSSFTEPKYR LAYCEAEDGS TTSEIVLASG PNEGLQPHLL WQLQKLISVV 180
  181 NTRKCERAFV SAKVFTSSLE PQLRSKLADS EHLYEVLPAF IKSLAVDLEM CPGIRDRETR 240
  241 SLFISSALHT PNKNEPPMET FLSLFHFLPE EYDSNLYKMF NVLLYPEEEE EEEDVIRGGE 300
  301 QEEARYVEPE NTLKEVAPVL TILFNELETN TESVSLPNGV DIPLEFYPQL YTKQCKDQLI 360
  361 RHIISKRKQA RTRSRCLLQE INELKSYQGK NISTILESTL AYLQTIPDDA NNEAAKQIAS 420
  421 LKDTLNSARA AKMEEYKDLA SKLHGEWNLS HPETHIINTA KQLGLIENPY ILTMAALSPY 480
  481 SYFIRSRNGA WSWIQSNTLG TEFKVKKCSS PSVVQEAIKH GTKYASETPL MFIYCEEGKI 540
  541 PTEEVVAEAL KSNSGCLKFA EDDQNSLKTL RSQFFDGMGD PEQATNNINN GNDNDNDDDI 600
  601 DSDN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [149-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPTVVLPLPL NSLIESYFGL FALLTAVYFP HVFLKPDFKD LNYRADWFKG SSFTEPKYRL  60
   61 AYCEAEDGST TSEIVLASGP NEGLQPHLLW QLQKLISVVN TRKCERAFVS AKVFTSSLEP 120
  121 QLRSKLADSE HLYEVLPAFI KSLAVDLEMC PGIRDRETRS LFISSALHTP NKNEPPMETF 180
  181 LSLFHFLPEE YDSNLYKMFN VLLYPEEEEE EEDVIRGGEQ EEARYVEPEN TLKEVAPVLT 240
  241 ILFNELETNT ESVSLPNGVD IPLEFYPQLY TKQCKDQLIR HIISKRKQAR TRSRCLLQEI 300
  301 NELKSYQGKN ISTILESTLA YLQTIPDDAN NEAAKQIASL KDTLNSARAA KMEEYKDLAS 360
  361 KLHGEWNLSH PETHIINTAK QLGLIENPYI LTMAALSPYS YFIRSRNGAW SWIQSNTLGT 420
  421 EFKVKKCSSP SVVQEAIKHG TKYASETPLM FIYCEEGKIP TEEVVAEALK SNSGCLKFAE 480
  481 DDQNSLKTLR SQFFDGMGDP EQATNNINNG NDNDNDDDID SDN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.1
Match: 1nb8A
Description: Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cysteine-type peptidase activity 6.0242292884398 bayes_pls_golite062009
small conjugating protein-specific protease activity 5.90858078304578 bayes_pls_golite062009
ubiquitin-specific protease activity 5.44933450089323 bayes_pls_golite062009
ubiquitin thiolesterase activity 3.74006277974234 bayes_pls_golite062009
SUMO-specific protease activity 2.21040757005122 bayes_pls_golite062009
thiolester hydrolase activity 2.11491900255607 bayes_pls_golite062009
binding 1.33631135736211 bayes_pls_golite062009
catalytic activity 0.995453662223124 bayes_pls_golite062009
protein binding 0.971758173254614 bayes_pls_golite062009
peptidase activity 0.906081979704688 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.771565725012421 bayes_pls_golite062009
hydrolase activity 0.60043152196744 bayes_pls_golite062009
nucleic acid binding 0.457218859985687 bayes_pls_golite062009
NEDD8-specific protease activity 0.286821085697906 bayes_pls_golite062009
DNA binding 0.178287899185051 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.153973186741348 bayes_pls_golite062009
endopeptidase activity 0.134447097497472 bayes_pls_golite062009
cysteine-type endopeptidase activity 0.0340549989533036 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle