YRC Public Data Repository - Protein Structure Prediction

Protein:	FRE3
Organism:	Saccharomyces cerevisiae
Length:	711 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE3.

Description	E-value	Query Range	Subject Range
FRE3_YEAST - Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ... gi\|151945455 - gi\|151945455\|gb\|EDN63698.1\| ferric reductase transmembrane component [Saccharomyces cerevisiae YJM78... FRE3 - Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced... gi\|190407670 - gi\|190407670\|gb\|EDV10937.1\| ferric reductase transmembrane component [Saccharomyces cerevisiae RM11-...	0.0	[1..711]	[1..711]
gi\|3242456 - gi\|3242456\|dbj\|BAA28953.1\| Atrboh F [Arabidopsis thaliana]	0.0	[23..708]	[186..944]
gi\|28268678 - gi\|28268678\|dbj\|BAC56864.1\| respiratory burst oxidase homolog [Nicotiana benthamiana]	0.0	[30..708]	[204..962]
RBOHB_SOLTU - Respiratory burst oxidase homolog protein B OS=Solanum tuberosum GN=RBOHB PE=1 SV=1	0.0	[25..708]	[122..867]
gi\|17384016 - gi\|17384016\|emb\|CAC87256.1\| NADPH oxidase [Nicotiana tabacum]	0.0	[30..708]	[204..962]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[23..708]	[186..977]

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Predicted Domain #1

Region A:
Residues: [1-188]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYWVLLCGSI LLCCLSGASA SPAKTKMYGK LPLVLTDACM GVLGEVTWEY SSDDLYSSPA  60
   61 CTYEPALQSM LYCIYESLNE KGYSNRTFEK TFAAIKEDCA YYTDNLQNMT NADFYNMLNN 120
  121 GTTYIIQYSE GSANLTYPIE MDAQVRENYY YSYHGFYANY DIGHTYGGII CAYFVGVMIL 180
  181 ASILHYLS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.30103
Match:	1g8iA_
Description:	Frequenin (neuronal calcium sensor 1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cation binding	2.62077305565026	bayes_pls_golite062009
metal ion binding	2.62077305565026	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.61874575467092	bayes_pls_golite062009
ion binding	2.61312132078717	bayes_pls_golite062009
ion transmembrane transporter activity	2.57032504567157	bayes_pls_golite062009
cation transmembrane transporter activity	2.55650624542181	bayes_pls_golite062009
binding	2.54774920478325	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.37465721152046	bayes_pls_golite062009
cation channel activity	1.49312394054212	bayes_pls_golite062009
calcium ion binding	1.40919295397643	bayes_pls_golite062009
transporter activity	1.15928534291452	bayes_pls_golite062009
protein binding	1.06263369232144	bayes_pls_golite062009
channel activity	1.05847414989139	bayes_pls_golite062009
passive transmembrane transporter activity	1.05847414989139	bayes_pls_golite062009
ion channel activity	1.0369591011376	bayes_pls_golite062009
substrate-specific channel activity	1.03529144716694	bayes_pls_golite062009
voltage-gated cation channel activity	0.986621437232479	bayes_pls_golite062009
transmembrane transporter activity	0.945691505472547	bayes_pls_golite062009
voltage-gated ion channel activity	0.910148857310729	bayes_pls_golite062009
potassium channel activity	0.906643355854798	bayes_pls_golite062009
voltage-gated channel activity	0.896351900356978	bayes_pls_golite062009
gated channel activity	0.855502499003241	bayes_pls_golite062009
voltage-gated potassium channel activity	0.810245330492755	bayes_pls_golite062009
substrate-specific transporter activity	0.693724160233023	bayes_pls_golite062009
transcription regulator activity	0.529057692398468	bayes_pls_golite062009
molecular transducer activity	0.503769734882556	bayes_pls_golite062009
signal transducer activity	0.503769734882556	bayes_pls_golite062009
hydrolase activity	0.378268353045111	bayes_pls_golite062009
nucleic acid binding	0.345084390599452	bayes_pls_golite062009
	0.34446792626966	bayes_pls_golite062009
channel regulator activity	0.32809521759917	bayes_pls_golite062009
active transmembrane transporter activity	0.246383459363256	bayes_pls_golite062009
DNA binding	0.14285249145193	bayes_pls_golite062009
cytoskeletal protein binding	0.0776924650284998	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [189-356]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTPFKTALFK QRLVRYVRRY LTIPTIWGKH ASSFSYLKIF TGFLPTRSEG VIILGYLVLH  60
   61 TVFLAYGYQY DPYNLIFDSR REQIARYVAD RSGVLAFAHF PLIALFAGRN NFLEFISGVK 120
  121 YTSFIMFHKW LGRMMFLDAV IHGAAYTSYS VFYKDWAASK EETYWQFG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [357-529]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAALCIVGVM VFFSLAMFRK FFYEAFLFLH IVLGALFFYT CWEHVVELSG IEWIYAAIAI  60
   61 WTIDRLIRIV RVSYFGFPKA SLQLVGDDII RVTVKRPVRL WKAKPGQYVF VSFLHHLYFW 120
  121 QSHPFTVLDS IIKDGELTII LKEKKGVTKL VKKYVCCNGG KASMRLAIEG PYG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.30103
Match:	1ndh__
Description:	cytochrome b5 reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [530-711]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSPVNNYDN VLLLTGGTGL PGPIAHAIKL GKTSAATGKQ FIKLVIAVRG FNVLEAYKPE  60
   61 LMCLEDLNVQ LHIYNTMEVP ALTPNDSLEI SQQDEKADGK GVVMATTLEQ SPNPVEFDGT 120
  121 VFHHGRPNVE KLLHEVGDLN GSLAVVCCGP PVFVDEVRDQ TANLVLEKPA KAIEYFEEYQ 180
  181 SW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.30103
Match:	1ndh__
Description:	cytochrome b5 reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.45374095556065	bayes_pls_golite062009
transferase activity	1.15480450573972	bayes_pls_golite062009
binding	1.13408475648113	bayes_pls_golite062009
oxidoreductase activity	0.27336340260908	bayes_pls_golite062009
protein binding	0.144900113694048	bayes_pls_golite062009
cofactor binding	0.0731141170494622	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: