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View Structure Prediction Details

Protein: AEP3
Organism: Saccharomyces cerevisiae
Length: 606 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AEP3.

Description E-value Query
Range
Subject
Range
PPR99_ARATH - Pentatricopeptide repeat-containing protein At1g63130, mitochondrial OS=Arabidopsis thaliana GN=At1g...
0.0 [33..601] [58..597]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [36..601] [63..599]
gi|32527604 - gi|32527604|gb|AAP86199.1| pentatricopeptide repeat-containing protein [Raphanus sativus]
0.0 [1..605] [62..648]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTLRCLTQA LSKSGREAPK LYQKVIFPGL FREGIPIANV KKVDEKIIDS PTSTSVNGEA  60
   61 KKIVRHGVKY EREQVKEYLS SLPTLTLSRK QIRDDYDEER AKRMYMFSKQ TNSSNKFQKL 120
  121 LTAKSQEFTR ELLTLLID

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.211 0.592 mRNA metabolic process a.118.1 ARM repeat
View Download 0.218 0.009 extrinsic to membrane a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.231 0.003 extrinsic to membrane d.112.1 Phoshotransferase/anion transport protein
View Download 0.226 0.001 extrinsic to membrane a.92.1 Carbamoyl phosphate synthetase, large subunit connection domain
View Download 0.211 N/A N/A a.26.1 4-helical cytokines

Predicted Domain #2
Region A:
Residues: [139-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CTSNEKNSGP ERFTRKFLKF SNDEIPPLPD FSKNPQLFEN YIGILSHTKF NFRSSSKLNG  60
   61 IVRKMLRHLL HPTNKTTLPL RSAQVYNDSI YFFSEHFDFA SCREIFAQMK AEGTKPNTIT 120
  121 FNLLLRNVVK NSHIRKTKHP DDEVLFYLRS MRNHGVFADV ITWTTCYNFL RDEVSRQLYI 180
  181 VQMGEHLGNF NVNFVYTVLR NGDYRAE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.231 N/A N/A d.112.1 Phoshotransferase/anion transport protein
View Download 0.226 N/A N/A a.92.1 Carbamoyl phosphate synthetase, large subunit connection domain
View Download 0.226 N/A N/A d.112.1 Phoshotransferase/anion transport protein
View Download 0.218 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.211 N/A N/A a.118.1 ARM repeat

Predicted Domain #3
Region A:
Residues: [346-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DCLKVLAANS LPISRKTFYL CIERLLNEEQ LETASKLLDY GFQHLKSNFK LDSEAMNHFM  60
   61 RVFANKGRSD LAFLCYNTCR KIYKIKPDSQ TFEMLFKALV RNGNTKNFGA VLQYIKDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1na0A_
Description: Designed protein cTPR3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.69757163267229 bayes_pls_golite062009
oxidoreductase activity 0.967526235944614 bayes_pls_golite062009
protein binding 0.931467806305272 bayes_pls_golite062009
RNA binding 0.675746721046834 bayes_pls_golite062009
transcription regulator activity 0.663212626739423 bayes_pls_golite062009
nucleic acid binding 0.54028771192401 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 0.465749123849318 bayes_pls_golite062009
hydrolase activity 0.443144569020145 bayes_pls_golite062009
DNA binding 0.36234393273743 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [464-606]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVSEGFGLRT SYWRTKADSI FKFGSPNTLS EKSIEKARKL LGNLIASEGE FSWKIWKESD  60
   61 SSQKKILRFL GCIPTTLRCT NTAQDHQKPT NLPSNISQKK REYRNRVKAI ATKAALEKRM 120
  121 AYIKDNDVAF KKELVKRRIV GEV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.285 0.618 mitochondrial inner membrane a.24.3 Cytochromes
View Download 0.330 0.116 mitochondrial inner membrane c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.290 0.044 extrinsic to membrane a.39.1 EF-hand
View Download 0.375 0.001 extrinsic to membrane a.63.1 Apolipophorin-III
View Download 0.286 N/A N/A a.183.1 Nop domain
View Download 0.273 N/A N/A a.47.2 t-snare proteins
View Download 0.271 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle