YRC Public Data Repository - Protein Structure Prediction

Protein:	HAA1
Organism:	Saccharomyces cerevisiae
Length:	694 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HAA1.

Description	E-value	Query Range	Subject Range
gi\|190407952 - gi\|190407952\|gb\|EDV11217.1\| transcriptional activator HAA1 [Saccharomyces cerevisiae RM11-1a] HAA1_YEAST - Transcriptional activator HAA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HAA1 PE=1... HAA1 - Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively en...	0.0	[1..694]	[1..694]
AMT1_CANGA - Metal-activated transcriptional activator protein AMT1 OS=Candida glabrata GN=AMT1 PE=1 SV=1 AMT1_CANGA - Metal-activated transcriptional activator protein AMT1 OS=Candida glabrata (strain ATCC 2001 / CBS 1...	1.0E-53	[1..263]	[1..248]
gi\|85097135 - gi\|85097135\|ref\|XP_960389.1\| hypothetical protein NCU04830 [Neurospora crassa OR74A] gi\|32407197, gi\|... - gi\|32407197\|ref\|XP_324187.1\| predicted protein [Neurospora crassa], gi\|28921879\|gb\|EAA31153.1\| predi...	5.0E-40	[2..109]	[1..99]
CRF1_YARLI - Copper resistance protein CRF1 OS=Yarrowia lipolytica GN=CRF1 PE=4 SV=1 CRF1_YARLI - Copper resistance protein CRF1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CRF1 PE=3 SV=1	5.0E-28	[1..212]	[1..200]
cuf1 - Cu metalloregulatory transcription factor Cuf1 CUF1_SCHPO - Metal-binding regulatory protein cuf1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cuf1...	3.0E-24	[1..70]	[1..70]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-21	[1..95]	[1..73]

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Predicted Domain #1

Region A:
Residues: [1-84]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLINGIKYA CERCIRGHRV TTCNHTDQPL MMIKPKGRPS TTCDYCKQLR KNKNANPEGV  60
   61 CTCGRLEKKK LAQKAKEEAR AKAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	117.0
Match:	1co4A_
Description:	Zinc domain conserved in yeast copper-regulated transcription factors
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA polymerase II transcription factor activity	3.46199909835403	bayes_pls_golite062009
transcription regulator activity	3.44900037030135	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	2.99240619437226	bayes_pls_golite062009
binding	2.00508289492248	bayes_pls_golite062009
ligand-regulated transcription factor activity	0.749213234767051	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [85-694]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKQRKQCTCG TDEVCKYHAQ KRHLRKSPSS SQKKGRSISR SQPMFERVLS STSLDSNMLS  60
   61 GHGALSDTSS ILTSTFLDSE PGVGKISKDY HHVPSLASIS SLQSSQSLDQ NFSIPQSPPL 120
  121 SSMSFNFLTG NINETNQNHS NHQHSKSGNN WQDSSVSLPA KADSRLNMMD KNNSVGLDLL 180
  181 GHSKRISPIS NSRVGEVSVP LEEYIPSDID GVGRVTDKSS LVYDWPFDES IERNFSTTAT 240
  241 AATGESKFDI NDNCNRINSK SYSKTNSMNG NGMNNSNNNN INSNGNDKNN NNSSRQEHQG 300
  301 NGLFDMFTDS SSISTLSRAN LLLQEKIGSQ ENSVKQENYS KNPQLRHQLT SRSRSFIHHP 360
  361 ANEYLKNTFG NSHSNDIGKG VEVLSLTPSF MDIPEKERET ERSPSSNYIT DRPFTRKPRS 420
  421 SSIDVNHRYP PMAPTTVATS PGALNNAVAS NLDDQLSLTS LNSQPSSIAN MMMDPSNLAE 480
  481 QSSIHSVPQS INSPRMPKTG SRQDKNIHTK KEERNPLNNI HDLSQLENVP DEMNQMFSPP 540
  541 LKSMNRPDAI RENSSSSNFI IQGNSMISTP SGRNDLPDTS PMSSIQTASP PSQLLTDQGF 600
  601 ADLDNFMSSL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: