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View Structure Prediction Details

Protein: HOS1
Organism: Saccharomyces cerevisiae
Length: 470 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOS1.

Description E-value Query
Range		 Subject
Range
HDAC1_MOUSE - Histone deacetylase 1 OS=Mus musculus GN=Hdac1 PE=1 SV=1
 0.0 [88..453] [5..389]
gi|61369536, gi|... - gi|61369536|gb|AAX43347.1| histone deacetylase 1 [synthetic construct], gi|30583783|gb|AAP36140.1| H...
 0.0 [88..453] [5..389]
HDAC1_PONPY - Histone deacetylase 1 - Pongo pygmaeus (Orangutan)
HDAC1 - histone deacetylase 1
gi|123995803, gi... - gi|61363144|gb|AAX42342.1| histone deacetylase 1 [synthetic construct], gi|60814459|gb|AAX36302.1| h...
HDAC1_PONAB - Histone deacetylase 1 OS=Pongo abelii GN=HDAC1 PE=2 SV=1
 0.0 [88..453] [5..389]
HDAC1_CHICK - Histone deacetylase 1 OS=Gallus gallus GN=HDAC1 PE=2 SV=1
 0.0 [88..452] [5..388]
HDA1B_XENLA - Probable histone deacetylase 1-B OS=Xenopus laevis GN=hdac1-b PE=1 SV=1
 0.0 [86..452] [3..388]
gi|31217962, gi|... - gi|31217962|ref|XP_316539.1| ENSANGP00000004321 [Anopheles gambiae str. PEST], gi|21299237|gb|EAA113...
 0.0 [86..463] [1..398]

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Predicted Domain #1
Region A:
Residues: [1-74] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKLVISTSI FQSQVADLLP CNNHQKSQLT YSLINAYDLL QHFDEVLTFP YARKDDLLEF  60
   61 HSKSYIDYLI NGRF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [75-238] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKMMAQDVNN PMVESKWSEL SELADNWNEK IDYNPSQDLQ RFTTRENLYN YYLNHSQALE  60
   61 NNMDCINNSE VPTNDKPTDT YILNSETKQY NLEGDCPIFS YLPMYCQVIT GATLNLLDHL 120
  121 SPTERLIGIN WDGGRHHAFK QRASGFCYIN DVVLLIQRLR KAKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 280.228787
Match: 1c3pA_
Description: HDAC homologue
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 12.8220438463909 bayes_pls_golite062009
histone deacetylase activity 12.6231784270509 bayes_pls_golite062009
deacetylase activity 11.5037545953213 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 9.39837596691907 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9.35288901670927 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 3.35999169984456 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 3.35999169984456 bayes_pls_golite062009
transcription regulator activity 3.05701986980927 bayes_pls_golite062009
hydrolase activity 2.48411098726406 bayes_pls_golite062009
histone methyltransferase activity (H3-K27 specific) 2.32426965373744 bayes_pls_golite062009
histone deacetylase activity (H3-K16 specific) 2.32426965373744 bayes_pls_golite062009
transcription factor binding 2.19991964087943 bayes_pls_golite062009
nucleic acid binding 2.09632179671955 bayes_pls_golite062009
DNA binding 1.982290944939 bayes_pls_golite062009
binding 1.948738669065 bayes_pls_golite062009
transcription repressor activity 1.86169983561723 bayes_pls_golite062009
protein binding 1.77599011146146 bayes_pls_golite062009
catalytic activity 1.68836803454021 bayes_pls_golite062009
transcription activator activity 1.31578100431097 bayes_pls_golite062009
transcription factor activity 1.24596588472933 bayes_pls_golite062009
transcription cofactor activity 0.84972377395539 bayes_pls_golite062009
transcription corepressor activity 0.75415729284699 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 0.436815987851993 bayes_pls_golite062009
specific transcriptional repressor activity 0.23239615682673 bayes_pls_golite062009
tubulin deacetylase activity 0.12704421781224 bayes_pls_golite062009
chromatin binding 0.104097933861351 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [239-470] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKITYVDFDL HHGDGVEKAF QYSKQIQTIS VHLYEPGFFP GTGSLSDSRK DKNVVNIPLK  60
   61 HGCDDNYLEL IASKIVNPLI ERHEPEALII ECGGDGLLGD RFNEWQLTIR GLSRIIINIM 120
  121 KSYPRAHIFL LGGGGYNDLL MSRFYTYLTW CVTKQFSNLR CGDNNSFQID PFDVCDGDDS 180
  181 EQFIREHDLV EMYNEENYQY WIYEMEGSSR MKMLRNDNKD RDMVELMKFY EL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 280.228787
Match: 1c3pA_
Description: HDAC homologue
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle