YRC Public Data Repository - Protein Structure Prediction

Protein:	RRP46
Organism:	Saccharomyces cerevisiae
Length:	223 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RRP46.

Description	E-value	Query Range	Subject Range
RNPH_HAEIN - Ribonuclease PH OS=Haemophilus influenzae GN=rph PE=3 SV=1 RNPH_HAEIN - Ribonuclease PH OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=rph PE=3 SV... gi\|229844976, gi... - gi\|229844976\|ref\|ZP_04465113.1\| ribonuclease PH [Haemophilus influenzae 6P18H1], gi\|229812110\|gb\|EEP... RNPH_HAEI8 - Ribonuclease PH OS=Haemophilus influenzae (strain 86-028NP) GN=rph PE=3 SV=1	5.0E-51	[3..213]	[14..236]
RNPH_DECAR - Ribonuclease PH OS=Dechloromonas aromatica (strain RCB) GN=rph PE=3 SV=1	1.0E-50	[3..214]	[14..237]
RNPH_PSEA8 - Ribonuclease PH OS=Pseudomonas aeruginosa (strain LESB58) GN=rph PE=3 SV=1 gi\|254237972, gi... - gi\|84317970\|ref\|ZP_00966404.1\| COG0689: RNase PH [Pseudomonas aeruginosa C3719], gi\|254237972\|ref\|ZP... gi\|254243780, gi... - gi\|84323960\|ref\|ZP_00972025.1\| COG0689: RNase PH [Pseudomonas aeruginosa 2192], gi\|254243780\|ref\|ZP_... RNPH_PSEAB - Ribonuclease PH OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=rph PE=3 SV=1 RNPH_PSEAE - Ribonuclease PH OS=Pseudomonas aeruginosa GN=rph PE=1 SV=2 RNPH_PSEAE - Ribonuclease PH OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=r...	1.0E-50	[3..215]	[15..239]
RNPH_PHOLL - Ribonuclease PH OS=Photorhabdus luminescens subsp. laumondii GN=rph PE=3 SV=1 RNPH_PHOLL - Ribonuclease PH OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) ...	1.0E-50	[3..217]	[14..240]
RNPH_PSEP1 - Ribonuclease PH OS=Pseudomonas putida (strain F1 / ATCC 700007) GN=rph PE=3 SV=1 RNPH_PSEPK - Ribonuclease PH OS=Pseudomonas putida (strain KT2440) GN=rph PE=3 SV=1 tr\|I7CBE4\|I7CBE4... - Ribonuclease PH OS=Pseudomonas putida (strain DOT-T1E) GN=rph PE=3 SV=1	1.0E-50	[2..215]	[14..240]
PNP_CALS4 - Polyribonucleotide nucleotidyltransferase OS=Caldanaerobacter subterraneus subsp. tengcongensis (str... PNP_THETN - Polyribonucleotide nucleotidyltransferase OS=Thermoanaerobacter tengcongensis GN=pnp PE=3 SV=1	3.0E-50	[3..219]	[325..545]
RNPH_CHRVO - Ribonuclease PH OS=Chromobacterium violaceum GN=rph PE=3 SV=1 RNPH_CHRVO - Ribonuclease PH OS=Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 ...	5.0E-50	[3..214]	[14..237]
gi\|8102038 - gi\|8102038\|gb\|AAF72714.1\|AF263927_2 ribonuclease PH [Carnobacterium sp. St2]	8.0E-50	[3..222]	[14..246]
PNP_RHILO - Polyribonucleotide nucleotidyltransferase OS=Rhizobium loti (strain MAFF303099) GN=pnp PE=3 SV=1 PNP_RHILO - Polyribonucleotide nucleotidyltransferase OS=Rhizobium loti GN=pnp PE=3 SV=1	9.0E-50	[3..223]	[329..559]
PNP_RHIME - Polyribonucleotide nucleotidyltransferase OS=Rhizobium meliloti GN=pnp PE=3 SV=1 PNP_RHIME - Polyribonucleotide nucleotidyltransferase OS=Rhizobium meliloti (strain 1021) GN=pnp PE=3 SV=1	1.0E-49	[3..223]	[329..559]

Back

Predicted Domain #1

Region A:
Residues: [1-223]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVQAEIGIL DHVDGSSEFV SQDTKVICSV TGPIEPKARQ ELPTQLALEI IVRPAKGVAT  60
   61 TREKVLEDKL RAVLTPLITR HCYPRQLCQI TCQILESGED EAEFSLRELS CCINAAFLAL 120
  121 VDAGIALNSM CASIPIAIIK DTSDIIVDPT AEQLKISLSV HTLALEFVNG GKVVKNVLLL 180
  181 DSNGDFNEDQ LFSLLELGEQ KCQELVTNIR RIIQDNISPR LVV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.522879
Match:	1r6mA_
Description:	Crystal Structure Of The tRNA Processing Enzyme Rnase pH From Pseudomonas Aeruginosa In Complex With Phosphate
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
exoribonuclease activity	7.55877202113513	bayes_pls_golite062009
ribonuclease activity	7.54644729272203	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	7.5310318714913	bayes_pls_golite062009
3'-5'-exoribonuclease activity	6.46930372693262	bayes_pls_golite062009
3'-5' exonuclease activity	4.29895100594643	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	3.83939403332553	bayes_pls_golite062009
exonuclease activity	3.40686901061667	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.86434572018929	bayes_pls_golite062009
RNA binding	2.05527376734941	bayes_pls_golite062009
hydrolase activity	1.55476709794855	bayes_pls_golite062009
structural constituent of ribosome	1.2826764117718	bayes_pls_golite062009
transcription regulator activity	1.20748032530392	bayes_pls_golite062009
mRNA binding	1.17402119891853	bayes_pls_golite062009
nucleic acid binding	1.05662964529454	bayes_pls_golite062009
structural molecule activity	0.9404621246304	bayes_pls_golite062009
binding	0.907487229190259	bayes_pls_golite062009
catalytic activity	0.878454819018611	bayes_pls_golite062009
DNA binding	0.828609700556836	bayes_pls_golite062009
nuclease activity	0.69721312877891	bayes_pls_golite062009
carbohydrate kinase activity	0.51810239718467	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0287026367466632	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: