Protein: | MDL2 |
Organism: | Saccharomyces cerevisiae |
Length: | 773 amino acids |
Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDL2.
Description | E-value | Query Range |
Subject Range |
|
0.0 | [1..773] | [1..773] |
|
0.0 | [3..693] | [600..1285] |
|
0.0 | [3..683] | [597..1272] |
|
0.0 | [3..688] | [603..1283] |
|
0.0 | [3..683] | [598..1273] |
|
0.0 | [3..683] | [598..1273] |
|
0.0 | [3..683] | [591..1266] |
Region A: Residues: [1-100] |
1 11 21 31 41 51 | | | | | | 1 MLNGRLPLLR LGICRNMLSR PRLAKLPSIR FRSLVTPSSS QLIPLSRLCL RSPAVGKSLI 60 61 LQSFRCNSSK TVPETSLPSA SPISKGSARS AHAKEQSKTD |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
Region A: Residues: [101-698] |
1 11 21 31 41 51 | | | | | | 1 DYKDIIRLFM LAKRDWKLLL TAILLLTISC SIGMSIPKVI GIVLDTLKTS SGSDFFDLKI 60 61 PIFSLPLYEF LSFFTVALLI GCAANFGRFI LLRILSERVV ARLRANVIKK TLHQDAEFFD 120 121 NHKVGDLISR LGSDAYVVSR SMTQKVSDGV KALICGVVGV GMMCSLSPQL SILLLFFTPP 180 181 VLFSASVFGK QIRNTSKDLQ EATGQLTRVA EEQLSGIKTV QSFVAEGNEL SRYNVAIRDI 240 241 FQVGKTAAFT NAKFFTTTSL LGDLSFLTVL AYGSYLVLQS QLSIGDLTAF MLYTEYTGNA 300 301 VFGLSTFYSE IMQGAGAASR LFELTDRKPS ISPTVGHKYK PDRGVIEFKD VSFSYPTRPS 360 361 VQIFKNLNFK IAPGSSVCIV GPSGRGKSTI ALLLLRYYNP TTGTITIDNQ DISKLNCKSL 420 421 RRHIGIVQQE PVLMSGTIRD NITYGLTYTP TKEEIRSVAK QCFCHNFITK FPNTYDTVIG 480 481 PHGTLLSGGQ KQRIAIARAL IKKPTILILD EATSALDVES EGAINYTFGQ LMKSKSMTIV 540 541 SIAHRLSTIR RSENVIVLGH DGSVVEMGKF KELYANPTSA LSQLLNEKAA PGPSDQQL |
Detection Method: | ![]() |
Confidence: | 112.0 |
Match: | 1pf4A_ |
Description: | Multidrug resistance ABC transporter MsbA, C-terminal domain; Multidrug resistance ABC transporter MsbA, N-terminal domain |
Matching Structure (courtesy of the PDB):![]() |
Term | Confidence | Notes |
lipid transporter activity | 7.47642599298853 | bayes_pls_golite062009 |
ATPase activity, coupled to transmembrane movement of substances | 5.57844095962502 | bayes_pls_golite062009 |
ATPase activity, coupled to movement of substances | 5.57813579764186 | bayes_pls_golite062009 |
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | 5.57813579764186 | bayes_pls_golite062009 |
P-P-bond-hydrolysis-driven transmembrane transporter activity | 5.5689620139321 | bayes_pls_golite062009 |
primary active transmembrane transporter activity | 5.55992639965745 | bayes_pls_golite062009 |
active transmembrane transporter activity | 5.50005167063544 | bayes_pls_golite062009 |
ATPase activity, coupled | 4.98276715440477 | bayes_pls_golite062009 |
heme transporter activity | 4.82479229680991 | bayes_pls_golite062009 |
peptide transporter activity | 4.7442815698413 | bayes_pls_golite062009 |
anion transmembrane-transporting ATPase activity | 4.71935767060308 | bayes_pls_golite062009 |
ATPase activity | 4.69795387297193 | bayes_pls_golite062009 |
peptide-transporting ATPase activity | 4.63590351019108 | bayes_pls_golite062009 |
nucleoside-triphosphatase activity | 4.45923622153365 | bayes_pls_golite062009 |
pyrophosphatase activity | 4.39781350157199 | bayes_pls_golite062009 |
hydrolase activity, acting on acid anhydrides | 4.38133275795019 | bayes_pls_golite062009 |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 4.38085303582726 | bayes_pls_golite062009 |
cofactor transporter activity | 4.34709589308604 | bayes_pls_golite062009 |
oligopeptide-transporting ATPase activity | 4.09365342567844 | bayes_pls_golite062009 |
transporter activity | 3.71239480053329 | bayes_pls_golite062009 |
hydrogen ion transporting ATP synthase activity, rotational mechanism | 3.57926427233638 | bayes_pls_golite062009 |
ion transmembrane transporter activity | 3.35436118751376 | bayes_pls_golite062009 |
phosphate transmembrane-transporting ATPase activity | 3.20894563245332 | bayes_pls_golite062009 |
inorganic anion transmembrane transporter activity | 3.16975154423199 | bayes_pls_golite062009 |
hydrolase activity | 3.14498892233323 | bayes_pls_golite062009 |
transmembrane transporter activity | 3.13960906549884 | bayes_pls_golite062009 |
anion transmembrane transporter activity | 3.13913638619234 | bayes_pls_golite062009 |
substrate-specific transporter activity | 3.1318898376276 | bayes_pls_golite062009 |
cation transmembrane transporter activity | 3.08390071341252 | bayes_pls_golite062009 |
iron ion transmembrane transporter activity | 3.05511942104215 | bayes_pls_golite062009 |
ATP binding | 3.01346604299372 | bayes_pls_golite062009 |
substrate-specific transmembrane transporter activity | 3.00745742755195 | bayes_pls_golite062009 |
drug transmembrane transporter activity | 2.97119034312001 | bayes_pls_golite062009 |
adenyl ribonucleotide binding | 2.96271391116269 | bayes_pls_golite062009 |
adenyl nucleotide binding | 2.91131545957759 | bayes_pls_golite062009 |
metal ion transmembrane transporter activity | 2.88476360771975 | bayes_pls_golite062009 |
purine ribonucleotide binding | 2.70262534541085 | bayes_pls_golite062009 |
ribonucleotide binding | 2.70178191749524 | bayes_pls_golite062009 |
amine-transporting ATPase activity | 2.69529191205818 | bayes_pls_golite062009 |
organic acid transmembrane transporter activity | 2.67957846350199 | bayes_pls_golite062009 |
carboxylic acid transmembrane transporter activity | 2.67815672695824 | bayes_pls_golite062009 |
purine nucleotide binding | 2.6583477492092 | bayes_pls_golite062009 |
nucleotide binding | 2.62374702628143 | bayes_pls_golite062009 |
hydrogen ion transmembrane transporter activity | 2.61311581579476 | bayes_pls_golite062009 |
sterol transporter activity | 2.48473697371886 | bayes_pls_golite062009 |
inorganic cation transmembrane transporter activity | 2.40292717311506 | bayes_pls_golite062009 |
amine transmembrane transporter activity | 2.29486577878686 | bayes_pls_golite062009 |
2.20174656498665 | bayes_pls_golite062009 | |
vitamin transporter activity | 2.1653565229854 | bayes_pls_golite062009 |
phosphate transmembrane transporter activity | 2.15147988861177 | bayes_pls_golite062009 |
oligopeptide transporter activity | 2.05580564974083 | bayes_pls_golite062009 |
L-aspartate transmembrane transporter activity | 2.05274761921715 | bayes_pls_golite062009 |
binding | 1.84115074893083 | bayes_pls_golite062009 |
transition metal ion transmembrane transporter activity | 1.82177108193332 | bayes_pls_golite062009 |
organic anion transmembrane transporter activity | 1.76999970080179 | bayes_pls_golite062009 |
amino acid transmembrane transporter activity | 1.59627719545436 | bayes_pls_golite062009 |
monovalent inorganic cation transmembrane transporter activity | 1.58971273330352 | bayes_pls_golite062009 |
nucleic acid binding | 1.52921795164482 | bayes_pls_golite062009 |
phosphonate transmembrane transporter activity | 1.40269234722336 | bayes_pls_golite062009 |
cation channel activity | 1.33585529285301 | bayes_pls_golite062009 |
molybdate transmembrane-transporting ATPase activity | 1.28313088935613 | bayes_pls_golite062009 |
molybdate ion transmembrane transporter activity | 1.28313088935613 | bayes_pls_golite062009 |
ATPase activity, coupled to transmembrane movement of ions | 1.23799860254751 | bayes_pls_golite062009 |
DNA binding | 1.19966224604123 | bayes_pls_golite062009 |
potassium channel activity | 1.17288958041707 | bayes_pls_golite062009 |
sulfate transmembrane-transporting ATPase activity | 1.1220946941463 | bayes_pls_golite062009 |
transcription regulator activity | 1.09075553688438 | bayes_pls_golite062009 |
protein transporter activity | 1.05248757342537 | bayes_pls_golite062009 |
dipeptide transporter activity | 1.01130176523309 | bayes_pls_golite062009 |
voltage-gated cation channel activity | 1.00384984515681 | bayes_pls_golite062009 |
thiamin transmembrane transporter activity | 0.933872128802939 | bayes_pls_golite062009 |
voltage-gated ion channel activity | 0.889208591820696 | bayes_pls_golite062009 |
motor activity | 0.87979065815418 | bayes_pls_golite062009 |
voltage-gated channel activity | 0.871525745291603 | bayes_pls_golite062009 |
structural constituent of ribosome | 0.860102064846772 | bayes_pls_golite062009 |
ion channel activity | 0.848261056209476 | bayes_pls_golite062009 |
GTPase activity | 0.83849854735032 | bayes_pls_golite062009 |
channel activity | 0.806331380134838 | bayes_pls_golite062009 |
passive transmembrane transporter activity | 0.806331380134838 | bayes_pls_golite062009 |
substrate-specific channel activity | 0.799997700906738 | bayes_pls_golite062009 |
copper ion transmembrane transporter activity | 0.798934081014025 | bayes_pls_golite062009 |
di-, tri-valent inorganic cation transmembrane transporter activity | 0.767424210804186 | bayes_pls_golite062009 |
gated channel activity | 0.650050847753837 | bayes_pls_golite062009 |
cholesterol transporter activity | 0.644421039250979 | bayes_pls_golite062009 |
branched-chain aliphatic amino acid transmembrane transporter activity | 0.442220326523999 | bayes_pls_golite062009 |
ligase activity | 0.417681194526243 | bayes_pls_golite062009 |
catalytic activity | 0.368034275052766 | bayes_pls_golite062009 |
oxidoreductase activity | 0.311483600813201 | bayes_pls_golite062009 |
translation regulator activity | 0.29096092258568 | bayes_pls_golite062009 |
signal transducer activity | 0.286367085584159 | bayes_pls_golite062009 |
molecular transducer activity | 0.286367085584159 | bayes_pls_golite062009 |
translation factor activity, nucleic acid binding | 0.274994961137851 | bayes_pls_golite062009 |
neutral amino acid transmembrane transporter activity | 0.227570438294493 | bayes_pls_golite062009 |
protein binding | 0.170837278876362 | bayes_pls_golite062009 |
amino acid-transporting ATPase activity | 0.147644650870465 | bayes_pls_golite062009 |
structural molecule activity | 0.11239762372728 | bayes_pls_golite062009 |
sulfate transmembrane transporter activity | 0.104477131120205 | bayes_pls_golite062009 |
transcription factor activity | 0.0612932659603008 | bayes_pls_golite062009 |
cation-transporting ATPase activity | 0.0536898657672154 | bayes_pls_golite062009 |
Region A: Residues: [699-773] |
1 11 21 31 41 51 | | | | | | 1 QIEKVIEKED LNESKEHDDQ KKDDNDDNDN NHDNDSNNQS PETKDNNSDD IEKSVEHLLK 60 61 DAAKEANPIK ITPQP |
Detection Method: | ![]() |
Confidence: | 50.69897 |
Match: | 1q12A_ |
Description: | Crystal Structure of the ATP-bound E. coli MalK |
Matching Structure (courtesy of the PDB):![]() |