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View Structure Prediction Details

Protein: GPC4
Organism: Homo sapiens
Length: 556 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPC4.

Description E-value Query
Range
Subject
Range
gi|109132298 - gi|109132298|ref|XP_001097252.1| PREDICTED: similar to glypican 4 [Macaca mulatta]
842.0 [0..1] [556..1]
gi|3420277 - gi|3420277|gb|AAC31899.1| glypican 4 [Homo sapiens]
831.0 [0..1] [556..1]
gi|74008970 - gi|74008970|ref|XP_549265.2| PREDICTED: similar to glypican 4 [Canis familiaris]
825.0 [0..1] [556..1]
gi|55726366 - gi|55726366|emb|CAH89953.1| hypothetical protein [Pongo abelii]
GPC6_PONAB - Glypican-6 OS=Pongo abelii GN=GPC6 PE=2 SV=1
816.0 [0..21] [556..21]
GPC6_MOUSE - Glypican-6 OS=Mus musculus GN=Gpc6 PE=1 SV=1
811.0 [0..20] [556..20]
gi|62078949, gi|... - gi|62078949|ref|NP_001014130.1| glypican 4 [Rattus norvegicus], gi|51980590|gb|AAH81962.1| Glypican ...
805.0 [0..24] [556..24]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARFGLPALL CTLAVLSAAL LAAELKSKSC SEVRRLYVSK GFNKNDAPLH EINGDHLKIC  60
   61 PQGSTCCSQE MEEKYSLQSK DDFKSVVSEQ CNHLQAVFAS RYKKFD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.600 N/A N/A a.29.2 Bromodomain
View Download 0.501 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.497 N/A N/A a.29.2 Bromodomain
View Download 0.484 N/A N/A a.29.2 Bromodomain

Predicted Domain #2
Region A:
Residues: [107-237]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFFKELLENA EKSLNDMFVK TYGHLYMQNS ELFKDLFVEL KRYYVVGNVN LEEMLNDFWA  60
   61 RLLERMFRLV NSQYHFTDEY LECVSKYTEQ LKPFGDVPRK LKLQVTRAFV AARTFAQGLA 120
  121 VAGDVVSKVS V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.977 N/A N/A a.118.22 Description not found.
View Download 0.976 N/A N/A a.118.1 ARM repeat
View Download 0.958 N/A N/A a.29.16 Description not found.
View Download 0.951 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.931 N/A N/A a.24.4 Hemerythrin
View Download 0.920 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.918 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.864 N/A N/A a.1.1 Globin-like
View Download 0.848 N/A N/A a.160.1 Poly(A) polymerase, middle domain

Predicted Domain #3
Region A:
Residues: [238-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNPTAQCTHA LLKMIYCSHC RGLVTVKPCY NYCSNIMRGC LANQGDLDFE WNNFIDAMLM  60
   61 VAERLEGPF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.841 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.833 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.785 N/A N/A a.8.11 Description not found.
View Download 0.776 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.759 N/A N/A a.7.17 Description not found.
View Download 0.715 N/A N/A a.60.8 HRDC-like
View Download 0.699 N/A N/A a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.586 N/A N/A a.60.2 RuvA domain 2-like

Predicted Domain #4
Region A:
Residues: [307-431]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIESVMDPID VKISDAIMNM QDNSVQVSQK VFQGCGPPKP LPAGRISRSI SESAFSARFR  60
   61 PHHPEERPTT AAGTSLDRLV TDVKEKLKQA KKFWSSLPSN VCNDERMAAG NGNEDDCWNG 120
  121 KGKSR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.454 N/A N/A a.29.12 Description not found.
View Download 0.358 N/A N/A d.33.1 Bacterial protein-export protein SecB
View Download 0.348 N/A N/A f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.333 N/A N/A d.33.1 Bacterial protein-export protein SecB
View Download 0.301 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.298 N/A N/A c.23.14 Nucleoside 2-deoxyribosyltransferase
View Download 0.287 N/A N/A a.185.1 Gametocyte protein Pfg27
View Download 0.284 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.239 N/A N/A a.7.1 Spectrin repeat
View Download 0.220 N/A N/A a.7.1 Spectrin repeat

Predicted Domain #5
Region A:
Residues: [432-466]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YLFAVTGNGL ANQGNNPEVQ VDTSKPDILI LRQIM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [467-556]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALRVMTSKMK NAYNGNDVDF FDISDESSGE GSGSGCEYQQ CPSEFDYNAT DHAGKSANEK  60
   61 ADSAGVRPGA QAYLLTVFCI LFLVMQREWR 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.495 N/A N/A a.3.1 Cytochrome c
View Download 0.466 N/A N/A a.7.1 Spectrin repeat
View Download 0.454 N/A N/A a.3.1 Cytochrome c
View Download 0.350 N/A N/A a.3.1 Cytochrome c
View Download 0.337 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.328 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.325 N/A N/A a.3.1 Cytochrome c
View Download 0.220 N/A N/A d.198.1 Type III secretory system chaperone
View Download 0.211 N/A N/A a.130.1 Chorismate mutase II


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle