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View Structure Prediction Details

Protein: PRKCD
Organism: Homo sapiens
Length: 676 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRKCD.

Description E-value Query
Range
Subject
Range
PRKCD - protein kinase C, delta
689.0 [0..1] [676..1]
gi|119914588, gi... - gi|76678703|ref|XP_869213.1| PREDICTED: similar to protein kinase C, delta isoform 2 [Bos taurus], g...
688.0 [0..1] [676..1]
gi|33304013 - gi|33304013|gb|AAQ02514.1| protein kinase C, delta [synthetic construct]
687.0 [0..1] [676..1]
gi|149034217, gi... - gi|7019312|emb|CAB75578.1| protein kinase C delta [Rattus norvegicus], gi|49904281|gb|AAH76505.1| Pr...
679.0 [0..1] [675..1]
gi|74188228 - gi|74188228|dbj|BAE25785.1| unnamed protein product [Mus musculus]
679.0 [0..1] [675..1]

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Predicted Domain #1
Region A:
Residues: [1-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPFLRIAFN SYELGSLQAE DEANQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD  60
   61 AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120
  121 FLEDVDC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.30103
Match: 1yrkA
Description: The C2 Domain of PKC is a new Phospho-Tyrosine Binding Domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [128-191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQSMRSEDEA KFPTMNRRGA IKQAKIHYIK NHEFIATFFG QPTFCSVCKD FVWGLNKQGY  60
   61 KCRQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [192-617]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CNAAIHKKCI DKIIGRCTGT AANSRDTIFQ KERFNIDMPH RFKVHNYMSP TFCDHCGSLL  60
   61 WGLVKQGLKC EDCGMNVHHK CREKVANLCG INQKLLAEAL NQVTQRASRR SDSASSEPVG 120
  121 IYQGFEKKTG VAGEDMQDNS GTYGKIWEGS SKCNINNFIF HKVLGKGSFG KVLLGELKGR 180
  181 GEYSAIKALK KDVVLIDDDV ECTMVEKRVL TLAAENPFLT HLICTFQTKD HLFFVMEFLN 240
  241 GGDLMYHIQD KGRFELYRAT FYAAEIMCGL QFLHSKGIIY RDLKLDNVLL DRDGHIKIAD 300
  301 FGMCKENIFG ESRASTFCGT PDYIAPEILQ GLKYTFSVDW WSFGVLLYEM LIGQSPFHGD 360
  361 DEDELFESIR VDTPHYPRWI TKESKDILEK LFEREPTKRL GMTGNIKIHP FFKTINWTLL 420
  421 EKRRLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.69897
Match: 1opkA
Description: Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [618-676]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPFRPKVKSP RDYSNFDQEF LNEKARLSYS DKNLIDSMDQ SAFAGFSFVN PKFEHLLED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 102.0
Match: 1xjdA
Description: Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle