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View Structure Prediction Details

Protein: BRIX1
Organism: Homo sapiens
Length: 353 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BRIX1.

Description E-value Query
Range		 Subject
Range
gi|74212210 - gi|74212210|dbj|BAE40264.1| unnamed protein product [Mus musculus]
 3.0E-99 [1..353] [1..353]
gi|109076914 - gi|109076914|ref|XP_001089767.1| PREDICTED: BRIX [Macaca mulatta]
 5.0E-99 [1..353] [1..353]
BXDC2_PONPY - Brix domain-containing protein 2 - Pongo pygmaeus (Orangutan)
BRX1_PONAB - Ribosome biogenesis protein BRX1 homolog OS=Pongo abelii GN=BRIX1 PE=2 SV=1
 1.0E-98 [1..353] [1..353]
BRX1_BOVIN - Ribosome biogenesis protein BRX1 homolog OS=Bos taurus GN=BRIX1 PE=2 SV=1
 5.0E-98 [1..353] [1..353]
BRX1_RAT - Ribosome biogenesis protein BRX1 homolog OS=Rattus norvegicus GN=Brix1 PE=2 SV=1
 1.0E-97 [1..353] [1..352]
gi|19070357 - gi|19070357|gb|AAL83818.1|AF347667_1 BRIX [Homo sapiens]
 8.0E-97 [1..353] [1..354]
gi|114600702 - gi|114600702|ref|XP_517812.2| PREDICTED: similar to Brix domain containing 2 [Pan troglodytes]
 3.0E-91 [31..353] [5..327]
BRX1_XENLA - Ribosome biogenesis protein BRX1 homolog OS=Xenopus laevis GN=brix1 PE=2 SV=1
 1.0E-84 [1..347] [1..339]

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Predicted Domain #1
Region A:
Residues: [1-160] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAATKRKRRG GFAVQAKKPK RNEIDAEPPA KRHATAEEVE EEERDRIPGP VCKGKWKNKE  60
   61 RILIFSSRGI NFRTRHLMQD LRMLMPHSKA DTKMDRKDKL FVINEVCEMK NCNKCIYFEA 120
  121 KKKQDLYMWL SNSPHGPSAK FLVQNIHTLA ELKMTGNCLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 2cxhA
Description: Crystal structure of probable ribosomal biogenesis protein from Aeropyrum pernix K1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
aminoacyl-tRNA ligase activity 3.87211694771248 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 3.87184649959884 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 3.87184649959884 bayes_pls_golite062009
ligase activity 2.64230127203047 bayes_pls_golite062009
proline-tRNA ligase activity 2.35871952544841 bayes_pls_golite062009
binding 1.78917266819015 bayes_pls_golite062009
catalytic activity 0.902495165806215 bayes_pls_golite062009
protein binding 0.665778090365515 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [161-258] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSRPLLSFDP AFDELPHYAL LKELLIQIFS TPRYHPKSQP FVDHVFTFTI LDNRIWFRNF  60
   61 QIIEEDAALV EIGPRFVLNL IKIFQGSFGG PTLYENPH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.52
Match: 2cxhA
Description: Crystal structure of probable ribosomal biogenesis protein from Aeropyrum pernix K1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [259-353] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQSPNMHRRV IRSITAAKYR EKQQVKDVQK LRKKEPKTLL PHDPTADVFV TPAEEKPIEI  60
   61 QWVKPEPKVD LKARKKRIYK RQRKMKQRMD SGKTK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle