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View Structure Prediction Details

Protein: AQP3
Organism: Homo sapiens
Length: 292 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AQP3.

Description E-value Query
Range
Subject
Range
AQP3_BOVIN - Aquaporin-3 OS=Bos taurus GN=AQP3 PE=2 SV=1
1.0E-79 [1..292] [1..292]
gi|109111220 - gi|109111220|ref|XP_001099318.1| PREDICTED: aquaporin 3 [Macaca mulatta]
1.0E-79 [1..292] [1..292]
gi|60826783 - gi|60826783|gb|AAX36771.1| aquaporin 3 [synthetic construct]
1.0E-79 [1..292] [1..292]
gi|55633109 - gi|55633109|ref|XP_520531.1| PREDICTED: similar to aquaporin 3 isoform 2 [Pan troglodytes]
2.0E-79 [1..292] [1..292]
AQP3_MOUSE - Aquaporin-3 OS=Mus musculus GN=Aqp3 PE=1 SV=1
3.0E-79 [1..292] [1..292]
gi|49457003 - gi|49457003|emb|CAG46822.1| AQP3 [Homo sapiens]
3.0E-79 [1..292] [1..292]
gi|73971745 - gi|73971745|ref|XP_854596.1| PREDICTED: similar to Aquaporin 3 [Canis familiaris]
3.0E-79 [1..292] [1..292]
AQP3_RAT - Aquaporin-3 OS=Rattus norvegicus GN=Aqp3 PE=2 SV=1
3.0E-78 [1..292] [1..292]

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Predicted Domain #1
Region A:
Residues: [1-292]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR GTHGGFLTIN  60
   61 LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK LPIYTLAQTL GAFLGAGIVF 120
  121 GLYYDAIWHF ADNQLFVSGP NGTAGIFATY PSGHLDMING FFDQFIGTAS LIVCVLAIVD 180
  181 PYNNPVPRGL EAFTVGLVVL VIGTSMGFNS GYAVNPARDF GPRLFTALAG WGSAVFTTGQ 240
  241 HWWWVPIVSP LLGSIAGVFV YQLMIGCHLE QPPPSNEEEN VKLAHVKHKE QI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.69897
Match: 1fx8A
Description: Glycerol uptake facilitator protein GlpF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
water transmembrane transporter activity 10.3414560257964 bayes_pls_golite062009
water channel activity 10.2169080705067 bayes_pls_golite062009
amide transmembrane transporter activity 8.22334514934522 bayes_pls_golite062009
urea channel activity 8.22334514934522 bayes_pls_golite062009
urea transmembrane transporter activity 8.22334514934522 bayes_pls_golite062009
glycerol transmembrane transporter activity 6.84984722645819 bayes_pls_golite062009
alcohol transmembrane transporter activity 6.65010837320829 bayes_pls_golite062009
polyol transmembrane transporter activity 6.65010837320829 bayes_pls_golite062009
substrate-specific channel activity 6.49777654791183 bayes_pls_golite062009
channel activity 6.47484344601535 bayes_pls_golite062009
passive transmembrane transporter activity 6.47484344601535 bayes_pls_golite062009
transporter activity 5.23077472964938 bayes_pls_golite062009
pyrimidine transmembrane transporter activity 5.22583580934587 bayes_pls_golite062009
substrate-specific transporter activity 5.06520190871345 bayes_pls_golite062009
transmembrane transporter activity 4.83314424546299 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.7450921192571 bayes_pls_golite062009
glycerol channel activity 4.65460547189577 bayes_pls_golite062009
ion transmembrane transporter activity 2.89377210429696 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity 2.87423888562609 bayes_pls_golite062009
cation transmembrane transporter activity 2.66719193997824 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.14052261196782 bayes_pls_golite062009
organic acid transmembrane transporter activity 1.57078059027065 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 1.57017437613762 bayes_pls_golite062009
cation channel activity 1.51074107596522 bayes_pls_golite062009
ion channel activity 1.40084800732756 bayes_pls_golite062009
nucleobase transmembrane transporter activity 1.34339324336864 bayes_pls_golite062009
purine transmembrane transporter activity 1.34339324336864 bayes_pls_golite062009
binding 1.29002883661034 bayes_pls_golite062009
amine transmembrane transporter activity 1.16825682067665 bayes_pls_golite062009
active transmembrane transporter activity 0.315342449421593 bayes_pls_golite062009
protein binding 0.279304481542405 bayes_pls_golite062009
structural molecule activity 0.180281371901848 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle