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View Structure Prediction Details

Protein: DPYSL2
Organism: Homo sapiens
Length: 572 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPYSL2.

Description E-value Query
Range
Subject
Range
gi|62898846 - gi|62898846|dbj|BAD97277.1| dihydropyrimidinase-like 2 variant [Homo sapiens]
0.0 [1..572] [1..572]
DPYL2_CHICK - Dihydropyrimidinase-related protein 2 OS=Gallus gallus GN=DPYSL2 PE=2 SV=1
0.0 [1..572] [1..572]
DPYL2_BOVIN - Dihydropyrimidinase-related protein 2 OS=Bos taurus GN=DPYSL2 PE=1 SV=1
0.0 [1..572] [1..572]
gi|73993705 - gi|73993705|ref|XP_858120.1| PREDICTED: similar to Dihydropyrimidinase related protein-2 (DRP-2) (Tu...
0.0 [1..572] [1..572]
DPYL2_MOUSE - Dihydropyrimidinase-related protein 2 OS=Mus musculus GN=Dpysl2 PE=1 SV=2
DPYL2_RAT - Dihydropyrimidinase-related protein 2 OS=Rattus norvegicus GN=Dpysl2 PE=1 SV=1
gi|599966 - gi|599966|emb|CAA86981.1| TOAD-64 [Rattus rattus]
0.0 [1..572] [1..572]
gi|114619343, gi... - gi|114619343|ref|XP_001161734.1| PREDICTED: dihydropyrimidinase-like 2 isoform 7 [Pan troglodytes], ...
0.0 [1..572] [1..572]
gi|30583791, gi|... - gi|60653359|gb|AAX29374.1| collapsin response mediator protein 1 [synthetic construct], gi|30583791|...
0.0 [1..572] [1..572]

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Predicted Domain #1
Region A:
Residues: [1-572]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI VPGGVKTIEA  60
   61 HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG TTMIIDHVVP EPGTSLLAAF 120
  121 DQWREWADSK SCCDYSLHVD ISEWHKGIQE EMEALVKDHG VNSFLVYMAF KDRFQLTDCQ 180
  181 IYEVLSVIRD IGAIAQVHAE NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRAI 240
  241 TIANQTNCPL YITKVMSKSS AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA 300
  301 FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL IPEGTNGTEE 360
  361 RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR IAVGSDADLV IWDPDSVKTI 420
  421 SAKTHNSSLE YNIFEGMECR GSPLVVISQG KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK 480
  481 RIKARSRLAE LRGVPRGLYD GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS 540
  541 LSGAQIDDNI PRRTTQRIVA PPGGRANITS LG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 102.0
Match: 1kcxA
Description: X-ray structure of NYSGRC target T-45
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
dihydropyrimidinase activity 5.22180471926674 bayes_pls_golite062009
uracil binding 2.6045173443981 bayes_pls_golite062009
pyrimidine binding 2.6045173443981 bayes_pls_golite062009
hydrolase activity 2.54288207838687 bayes_pls_golite062009
allantoinase activity 2.45571277189844 bayes_pls_golite062009
dihydroorotase activity 2.32070383330692 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2.20489529944693 bayes_pls_golite062009
deaminase activity 1.79186203771221 bayes_pls_golite062009
catalytic activity 1.70199291046899 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.60895003474033 bayes_pls_golite062009
adenine deaminase activity 1.4081199504179 bayes_pls_golite062009
thymine binding 1.34528530211689 bayes_pls_golite062009
binding 0.778600467259354 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.573107361273483 bayes_pls_golite062009
guanine deaminase activity 0.134430884998957 bayes_pls_golite062009
nucleic acid binding 0.0469543675220554 bayes_pls_golite062009
purine nucleoside binding 0.015278392159201 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle