YRC Public Data Repository - Protein Structure Prediction

Protein:	CCL13
Organism:	Homo sapiens
Length:	98 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCL13.

Description	E-value	Query Range	Subject Range
gi\|28894125 - gi\|28894125\|gb\|AAO52735.1\| monocyte chemoattractant protein-3 [Macaca nemestrina]	1.0E-28	[2..97]	[12..108]
gi\|109113971 - gi\|109113971\|ref\|XP_001113462.1\| PREDICTED: chemokine (C-C motif) ligand 13 [Macaca mulatta]	1.0E-28	[1..98]	[1..98]
gi\|164665382, gi... - gi\|57527998\|ref\|NP_001009579.1\| chemokine (C-C motif) ligand 3-like 1 [Sus scrofa], gi\|49354682\|gb\|A...	1.0E-28	[1..90]	[1..90]
gi\|114668172 - gi\|114668172\|ref\|XP_001174525.1\| PREDICTED: small inducible cytokine A13 [Pan troglodytes]	3.0E-28	[1..98]	[1..98]
gi\|47779271, gi\|... - gi\|47779271\|ref\|NP_001001437.1\| chemokine (C-C motif) ligand 3-like 3 precursor [Homo sapiens], gi\|3... gi\|60656295 - gi\|60656295\|gb\|AAX32711.1\| chemokine (C-C motif) ligand 3-like 1 [synthetic construct]	4.0E-28	[1..90]	[1..90]
CCL4_BOVIN - C-C motif chemokine 4 OS=Bos taurus GN=CCL4 PE=3 SV=1	5.0E-28	[1..90]	[1..90]
CCL4_RAT - C-C motif chemokine 4 OS=Rattus norvegicus GN=Ccl4 PE=3 SV=1	5.0E-28	[1..90]	[1..90]
gi\|30584489, gi\|... - gi\|60653245\|gb\|AAX29317.1\| chemokine (C-C motif) ligand 3-like 1 [synthetic construct], gi\|60653243\|...	5.0E-28	[1..90]	[1..90]

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Predicted Domain #1

Region A:
Residues: [1-98]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVSAVLLCL LLMTAAFNPQ GLAQPDALNV PSTCCFTFSS KKISLQRLKS YVITTSRCPQ  60
   61 KAVIFRTKLG KEICADPKEK WVQNYMKHLG RKAHTLKT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.69897
Match:	1bo0A
Description:	MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytokine activity	8.07273475133641	bayes_pls_golite062009
chemokine receptor binding	7.19574940007631	bayes_pls_golite062009
chemokine activity	7.19574940007631	bayes_pls_golite062009
G-protein-coupled receptor binding	7.12866319987718	bayes_pls_golite062009
receptor binding	5.70505228637425	bayes_pls_golite062009
protein binding	3.96178206863622	bayes_pls_golite062009
interleukin-8 receptor binding	3.86135397575984	bayes_pls_golite062009
binding	3.44333267537536	bayes_pls_golite062009
chemoattractant activity	3.05299139114464	bayes_pls_golite062009
heparin binding	2.48790323783525	bayes_pls_golite062009
glycosaminoglycan binding	1.80091312295242	bayes_pls_golite062009
CCR2 chemokine receptor binding	1.78317158345185	bayes_pls_golite062009
polysaccharide binding	1.28416986663426	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.2394639113112	bayes_pls_golite062009
kinase activity	1.20242374860894	bayes_pls_golite062009
protein kinase activity	1.20167556785693	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.05370662506053	bayes_pls_golite062009
pattern binding	1.02739535268516	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.0107537553708	bayes_pls_golite062009
CCR chemokine receptor binding	0.697359799598971	bayes_pls_golite062009
carbohydrate binding	0.14673741350408	bayes_pls_golite062009
catalytic activity	0.11400259673574	bayes_pls_golite062009
transporter activity	0.0541029584618528	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: