YRC Public Data Repository - Protein Structure Prediction

Protein:	LMNB1
Organism:	Homo sapiens
Length:	586 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LMNB1.

Description	E-value	Query Range	Subject Range
gi\|114560153 - gi\|114560153\|ref\|XP_513875.2\| PREDICTED: lamin A/C [Pan troglodytes]	2.0E-63	[3..550]	[438..984]
gi\|68388302 - gi\|68388302\|ref\|XP_696268.1\| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]	3.0E-52	[17..505]	[2135..2617]
gi\|109078430 - gi\|109078430\|ref\|XP_001097340.1\| PREDICTED: lamin B1 isoform 2 [Macaca mulatta]	3.0E-50	[1..586]	[1..586]
gi\|15126742 - gi\|15126742\|gb\|AAH12295.1\| Lamin B1 [Homo sapiens] gi\|123981378, gi... - gi\|157928174\|gb\|ABW03383.1\| lamin B1 [synthetic construct], gi\|123981378\|gb\|ABM82518.1\| lamin B1 [sy...	4.0E-50	[1..586]	[1..586]
gi\|110630, gi\|293689 - gi\|293689\|gb\|AAC96023.1\| lamin B [Mus musculus], pir\|\|S07720 lamin B - mouse	3.0E-49	[7..586]	[8..587]
LMNB1_RAT - Lamin-B1 OS=Rattus norvegicus GN=Lmnb1 PE=1 SV=3	2.0E-48	[1..586]	[1..587]

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Predicted Domain #1

Region A:
Residues: [1-330]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATATPVPPR MGSRAGGPTT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL  60
   61 QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKC KAEHDQLLLN 120
  121 YAKKESDLNG AQIKLREYEA ALNSKDAALA TALGDKKSLE GDLEDLKDQI AQLEASLAAA 180
  181 KKQLADETLL KVDLENRCQS LTEDLEFRKS MYEEEINETR RKHETRLVEV DSGRQIEYEY 240
  241 KLAQALHEMR EQHDAQVRLY KEELEQTYHA KLENARLSSE MNTSTVNSAR EELMESRMRI 300
  301 ESLSSQLSNL QKESRACLER IQELEDLLAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.522879
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [331-394]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKDNSRRMLT DKEREMAEIR DQMQQQLNDY EQLLDVKLAL DMEISAYRKL LEGEEERLKL  60
   61 SPSP

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.2
Match:	1gk6A
Description:	Vimentin coil
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [395-586]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSRVTVSRAS SSRSVRTTRG KRKRVDVEES EASSSVSISH SASATGNVCI EEIDVDGKFI  60
   61 RLKNTSEQDQ PMGGWEMIRK IGDTSVSYKY TSRYVLKAGQ TVTIWAANAG VTASPPTDLI 120
  121 WKNQNSWGTG EDVKVILKNS QGEEVAQRST VFKTTIPEEE EEEEEAAGVV VEEELFHQQG 180
  181 TPRASNRSCA IM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.69897
Match:	1ivtA
Description:	Lamin A/C globular tail domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural molecule activity	2.40638781086824	bayes_pls_golite062009
binding	2.29024114419453	bayes_pls_golite062009
protein binding	1.13460840277514	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: