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View Structure Prediction Details

Protein: DUSP9
Organism: Homo sapiens
Length: 384 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DUSP9.

Description E-value Query
Range
Subject
Range
gi|38174257 - gi|38174257|gb|AAH60837.1| DUSP9 protein [Homo sapiens]
2.0E-72 [1..384] [1..384]
gi|149029928, gi... - gi|83816929|ref|NP_001033062.1| dual specificity phosphatase 9 [Rattus norvegicus], gi|82414778|gb|A...
2.0E-71 [1..384] [1..414]
gi|109132712 - gi|109132712|ref|XP_001084096.1| PREDICTED: dual specificity phosphatase 9 [Macaca mulatta]
7.0E-71 [1..384] [1..384]
gi|73985361 - gi|73985361|ref|XP_541858.2| PREDICTED: similar to dual specificity phosphatase 7 isoform 1 [Canis f...
3.0E-69 [6..381] [42..400]
gi|38322768 - gi|38322768|gb|AAR16317.1| dual specificity phosphatase 6 [Tetraodon nigroviridis]
2.0E-68 [4..383] [17..380]
gi|38322721, gi|... - gi|38322721|gb|AAR16274.1| dual specificity phosphatase 6 [Takifugu rubripes], gi|17488591|gb|AAL403...
9.0E-68 [4..383] [17..379]
gi|76253883, gi|... - gi|76253883|ref|NP_956068.2| dual specificity phosphatase 7 [Danio rerio], gi|42744560|gb|AAH66600.1...
1.0E-67 [4..382] [2..359]
gi|76658903 - gi|76658903|ref|XP_870848.1| PREDICTED: similar to Dual specificity protein phosphatase 9 (Mitogen-a...
1.0E-67 [1..384] [180..559]

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Predicted Domain #1
Region A:
Residues: [1-164]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS  60
   61 VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA 120
  121 YYLQGGFSRF QAECPHLCET SLAGRAGSSM APVPGPVPVV GLGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.154902
Match: 1hzmA
Description: Erk2 binding domain of Mapk phosphatase mkp-3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoprotein phosphatase activity 4.79074052803751 bayes_pls_golite062009
phosphatase activity 4.46276380920308 bayes_pls_golite062009
phosphoric ester hydrolase activity 4.26891308022499 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 3.37977783690618 bayes_pls_golite062009
protein tyrosine phosphatase activity 2.84204105189999 bayes_pls_golite062009
hydrolase activity 2.12055507229256 bayes_pls_golite062009
binding 1.72957395505299 bayes_pls_golite062009
transferase activity 1.00600613068372 bayes_pls_golite062009
catalytic activity 0.687308230067573 bayes_pls_golite062009
protein binding 0.515609053278812 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [165-384]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LCLGSDCSDA ESEADRDSMS CGLDSEGATP PPVGLRASFP VQILPNLYLG SARDSANLES  60
   61 LAKLGIRYIL NVTPNLPNFF EKNGDFHYKQ IPISDHWSQN LSRFFPEAIE FIDEALSQNC 120
  121 GVLVHCLAGV SRSVTVTVAY LMQKLHLSLN DAYDLVKRKK SNISPNFNFM GQLLDFERSL 180
  181 RLEERHSQEQ GSGGQASAAS NPPSFFTTPT SDGAFELAPT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.39794
Match: 2hxpA
Description: No description for 2hxpA was found.

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