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View Structure Prediction Details

Protein: gi|12188746, gi|...
Organism: Homo sapiens
Length: 997 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|12188746, gi|....

Description E-value Query
Range
Subject
Range
RBGP1_PONAB - Rab GTPase-activating protein 1 OS=Pongo abelii GN=RABGAP1 PE=2 SV=1
RBGP1_PONPY - Rab GTPase-activating protein 1 - Pongo pygmaeus (Orangutan)
0.0 [1..997] [73..1069]
gi|114626582 - gi|114626582|ref|XP_520242.2| PREDICTED: hypothetical protein [Pan troglodytes]
0.0 [1..997] [5..1001]
gi|60360530 - gi|60360530|dbj|BAD90509.1| mKIAA4104 protein [Mus musculus]
0.0 [1..997] [74..1065]
gi|149047907, gi... - gi|62645029|ref|XP_231251.3| PREDICTED: similar to RAB GTPase activating protein 1 isoform a [Rattus...
0.0 [1..997] [73..1065]
gi|73968149 - gi|73968149|ref|XP_537854.2| PREDICTED: similar to RAB GTPase activating protein 1 isoform 1 [Canis ...
0.0 [1..997] [73..1069]

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Predicted Domain #1
Region A:
Residues: [1-228]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDQPGEKEL VKRSQLDGEG DGPLSNQLSA SSTINPVPLV GLQKPEMSLP VKPGQGDSEA  60
   61 SSPFTPVADE DSVVFSKLTY LGCASVNAPR SEVEALRMMS ILRSQCQISL DVTLSVPNVS 120
  121 EGIVRLLDPQ TNTEIANYPI YKILFCVRGH DGTPESDCFA FTESHYNAEL FRIHVFRCEI 180
  181 QEAVSRILYS FATAFRRSAK QTPLSATAAP QTPDSDIFTF SVSLEIKE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.31
Match: 2nmbA
Description: Numb
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.96397612302369 bayes_pls_golite062009
protein binding 1.85780451223644 bayes_pls_golite062009
cytoskeletal protein binding 1.3298316573981 bayes_pls_golite062009
actin binding 0.863119832306992 bayes_pls_golite062009
transporter activity 0.368466142481218 bayes_pls_golite062009
protein complex binding 0.317346496371944 bayes_pls_golite062009
transcription regulator activity 0.1902355170931 bayes_pls_golite062009
nucleic acid binding 0.0254091045498963 bayes_pls_golite062009
DNA binding 0.0185420422808378 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [229-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDGKGYFSAV PKDKDRQCFK LRQGIDKKIV IYVQQTTNKE LAIERCFGLL LSPGKDVRNS  60
   61 DMHLLDLESM GKSSDGKSYV ITGSWNPKSP HFQVVNEETP KDKVLFMTTA VDLVITEVQE 120
  121 PVRFLLETKV RVCSPNERLF WPFSKRSTTE NFFLKLKQIK QRERKNNTDT LYEVVCLESE 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [409-540]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SERERRKTTA SPSVRLPQSG SQSSVIPSPP EDDEEEDNDE PLLSGSGDVS KECAEKILET  60
   61 WGELLSKWHL NLNVRPKQLS SLVRNGVPEA LRGEVWQLLA GCHNNDHLVE KYRILITKES 120
  121 PQDSAITRDI NR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.30103
Match: 2qq8A
Description: No description for 2qq8A was found.

Predicted Domain #4
Region A:
Residues: [541-997]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFPAHDYFKD TGGDGQDSLY KICKAYSVYD EEIGYCQGQS FLAAVLLLHM PEEQAFSVLV  60
   61 KIMFDYGLRE LFKQNFEDLH CKFYQLERLM QEYIPDLYNH FLDISLEAHM YASQWFLTLF 120
  121 TAKFPLYMVF HIIDLLLCEG ISVIFNVALG LLKTSKDDLL LTDFEGALKF FRVQLPKRYR 180
  181 SEENAKKLME LACNMKISQK KLKKYEKEYH TMREQQAQQE DPIERFEREN RRLQEANMRL 240
  241 EQENDDLAHE LVTSKIALRK DLDNAEEKAD ALNKELLMTK QKLIDAEEEK RRLEEESAQL 300
  301 KEMCRRELDK AESEIKKNSS IIGDYKQICS QLSERLEKQQ TANKVEIEKI RQKVDDCERC 360
  361 REFFNKEGRV KGISSTKEVL DEDTDEEKET LKNQLREMEL ELAQTKLQLV EAECKIQDLE 420
  421 HHLGLALNEV QAAKKTWFNR TLSSIKTATG VQGKETC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.30103
Match: 2dfsA
Description: No description for 2dfsA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle