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View Structure Prediction Details

Protein: gi|1399443, gi|2...
Organism: Homo sapiens
Length: 244 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|1399443, gi|2....

Description E-value Query
Range
Subject
Range
gi|28913543 - gi|28913543|gb|AAH48734.1| Fgf8 protein [Mus musculus]
1.0E-69 [1..244] [1..244]
gi|46575705 - gi|46575705|gb|AAH69106.1| Fibroblast growth factor 8 (androgen-induced) [Homo sapiens]
6.0E-69 [1..244] [1..244]
gi|21700108 - gi|21700108|dbj|BAC02894.1| fibroblast growth factor 8 [Suncus murinus]
1.0E-66 [1..244] [1..244]
gi|76654957 - gi|76654957|ref|XP_612205.2| PREDICTED: fibroblast growth factor 8 (androgen-induced) [Bos taurus]
9.0E-63 [23..244] [187..397]
FGF8_CHICK - Fibroblast growth factor 8 OS=Gallus gallus GN=FGF8 PE=2 SV=1
9.0E-63 [1..243] [1..214]
gi|213624952, gi... - gi|27462802|gb|AAO15593.1|AF461177_1 fibroblast growth factor-8b [Xenopus laevis], gi|213626476|gb|A...
1.0E-62 [1..235] [1..206]
gi|51949976, gi|... - gi|56118518|ref|NP_001008163.1| fibroblast growth factor 8 (androgen-induced) [Xenopus (Silurana) tr...
1.0E-62 [1..235] [1..206]

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Predicted Domain #1
Region A:
Residues: [1-244]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQVTVQSSPN  60
   61 FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD 120
  121 TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM 180
  181 AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA 240
  241 PEPR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.69897
Match: 2fdbM
Description: Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
growth factor activity 5.6790632853895 bayes_pls_golite062009
fibroblast growth factor receptor binding 5.32138222782692 bayes_pls_golite062009
receptor binding 4.8109037277027 bayes_pls_golite062009
cytokine activity 3.23273280319483 bayes_pls_golite062009
protein binding 2.99442649109752 bayes_pls_golite062009
binding 2.26121569090272 bayes_pls_golite062009
heparin binding 2.1616134585534 bayes_pls_golite062009
glycosaminoglycan binding 2.0664969520492 bayes_pls_golite062009
polysaccharide binding 1.81686028727894 bayes_pls_golite062009
molecular transducer activity 1.16870777190189 bayes_pls_golite062009
signal transducer activity 1.16870777190189 bayes_pls_golite062009
transporter activity 0.901374747438933 bayes_pls_golite062009
interleukin-1 receptor binding 0.8084616632765 bayes_pls_golite062009
transmembrane transporter activity 0.718170110067115 bayes_pls_golite062009
substrate-specific transporter activity 0.507427648555795 bayes_pls_golite062009
pattern binding 0.323275442862789 bayes_pls_golite062009
nerve growth factor receptor binding 0.308245352535379 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.280573521182099 bayes_pls_golite062009
receptor signaling protein activity 0.146644241088165 bayes_pls_golite062009
ion transmembrane transporter activity 0.0138670393997913 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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