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View Structure Prediction Details

Protein: GPC6
Organism: Homo sapiens
Length: 555 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPC6.

Description E-value Query
Range
Subject
Range
gi|55726366 - gi|55726366|emb|CAH89953.1| hypothetical protein [Pongo abelii]
GPC6_PONAB - Glypican-6 OS=Pongo abelii GN=GPC6 PE=2 SV=1
879.0 [0..1] [555..1]
GPC6_MOUSE - Glypican-6 OS=Mus musculus GN=Gpc6 PE=1 SV=1
867.0 [0..1] [555..1]
gi|109502845 - gi|109502845|ref|XP_001074682.1| PREDICTED: similar to Glypican-6 precursor [Rattus norvegicus]
849.0 [0..1] [555..1]
gi|109132298 - gi|109132298|ref|XP_001097252.1| PREDICTED: similar to glypican 4 [Macaca mulatta]
802.0 [0..9] [555..9]
gi|123996633, gi... - gi|123996633|gb|ABM85918.1| glypican 4 [synthetic construct], gi|123981812|gb|ABM82735.1| glypican 4...
GPC4 - glypican 4
793.0 [0..9] [555..9]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSWIGAVIL PLLGLLLSLP AGADVKARSC GEVRQAYGAK GFSLADIPYQ EIAGEHLRIC  60
   61 PQEYTCCTTE MEDKLSQQSK LEFENLVEET SHFVRTTFVS RHKKFD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.705 N/A N/A a.46.1 Methionine synthase domain
View Download 0.434 N/A N/A a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.427 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.386 N/A N/A a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)

Predicted Domain #2
Region A:
Residues: [107-237]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFFRELLENA EKSLNDMFVR TYGMLYMQNS EVFQDLFTEL KRYYTGGNVN LEEMLNDFWA  60
   61 RLLERMFQLI NPQYHFSEDY LECVSKYTDQ LKPFGDVPRK LKIQVTRAFI AARTFVQGLT 120
  121 VGREVANRVS K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.962 N/A N/A a.24.4 Hemerythrin
View Download 0.928 N/A N/A a.118.1 ARM repeat
View Download 0.928 N/A N/A a.118.22 Description not found.
View Download 0.854 N/A N/A a.24.4 Hemerythrin
View Download 0.850 N/A N/A a.29.16 Description not found.
View Download 0.826 N/A N/A a.29.16 Description not found.
View Download 0.797 N/A N/A a.126.1 Serum albumin-like
View Download 0.743 N/A N/A a.118.8 TPR-like

Predicted Domain #3
Region A:
Residues: [238-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSPTPGCIRA LMKMLYCPYC RGLPTVRPCN NYCLNVMKGC LANQADLDTE WNLFIDAMLL  60
   61 VAERLEGPF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.920 N/A N/A a.2.3 Chaperone J-domain
View Download 0.920 N/A N/A a.2.3 Chaperone J-domain
View Download 0.784 N/A N/A a.272.1 Description not found.
View Download 0.754 N/A N/A a.7.14 Description not found.
View Download 0.733 N/A N/A a.24.20 Description not found.
View Download 0.704 N/A N/A a.17.1 p8-MTCP1
View Download 0.662 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.658 N/A N/A a.2.3 Chaperone J-domain
View Download 0.645 N/A N/A a.60.1 SAM/Pointed domain

Predicted Domain #4
Region A:
Residues: [307-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIESVMDPID VKISEAIMNM QENSMQVSAK VFQGCGQPKP APALRSARSA PENFNTRFRP  60
   61 YNPEERPTTA A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.483 N/A N/A a.28.2 Colicin E immunity proteins
View Download 0.447 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.381 N/A N/A a.64.1 Saposin
View Download 0.381 N/A N/A a.64.1 Saposin
View Download 0.377 N/A N/A a.4.1 Homeodomain-like
View Download 0.377 N/A N/A a.4.1 Homeodomain-like
View Download 0.360 N/A N/A a.4.1 Homeodomain-like
View Download 0.360 N/A N/A a.4.1 Homeodomain-like
View Download 0.352 N/A N/A a.64.2 Bacteriocin AS-48
View Download 0.342 N/A N/A a.64.1 Saposin

Predicted Domain #5
Region A:
Residues: [378-555]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTSLDRLVTD IKEKLKLSKK VWSALPYTIC KDESVTAGTS NEEECWNGHS KARYLPEIMN  60
   61 DGLTNQINNP EVDVDITRPD TFIRQQIMAL RVMTNKLKNA YNGNDVNFQD TSDESSGSGS 120
  121 GSGCMDDVCP TEFEFVTTEA PAVDPDRREV DSSAAQRGHS LLSWSLTCIV LALQRLCR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.471 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.471 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.272 N/A N/A a.213.1 Description not found.
View Download 0.254 N/A N/A a.25.1 Ferritin-like
View Download 0.250 N/A N/A a.24.3 Cytochromes
View Download 0.212 N/A N/A a.24.19 Description not found.


YRC Informatics Platform - Version 3.0
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