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View Structure Prediction Details

Protein: P4HA1
Organism: Homo sapiens
Length: 534 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for P4HA1.

Description E-value Query
Range
Subject
Range
gi|62897481, gi|... - pir||DAHUA1 procollagen-proline dioxygenase (EC 1.14.11.2) alpha chain precursor, splice form 1 - hu...
gi|114631173, gi... - gi|114631175|ref|XP_001140955.1| PREDICTED: prolyl 4-hydroxylase, alpha I subunit isoform 11 [Pan tr...
0.0 [1..534] [1..534]
gi|73952886 - gi|73952886|ref|XP_850682.1| PREDICTED: similar to prolyl 4-hydroxylase, alpha I subunit isoform 1 p...
0.0 [1..534] [1..534]
gi|74225936 - gi|74225936|dbj|BAE28745.1| unnamed protein product [Mus musculus]
0.0 [1..532] [1..532]
P4HA1_RAT - Prolyl 4-hydroxylase subunit alpha-1 OS=Rattus norvegicus GN=P4ha1 PE=2 SV=2
0.0 [1..534] [1..534]
P4HA1_BOVIN - Prolyl 4-hydroxylase subunit alpha-1 OS=Bos taurus GN=P4HA1 PE=1 SV=1
0.0 [1..534] [1..534]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIWYILIIGI LLPQSLAHPG FFTSIGQMTD LIHTEKDLVT SLKDYIKAEE DKLEQIKKWA  60
   61 EKLDRLTSTA TKDPEGFVGH PVNAFKLMKR LNTEWSELEN LVLKDMSDGF ISNLTIQRQY 120
  121 FPNDEDQVGA AKALLRLQDT YNLDTDTISK GNLPGVKHKS F

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 75.075721
Match: PF08336.2
Description: No description for PF08336.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [162-283]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTAEDCFELG KVAYTEADYY HTELWMEQAL RQLDEGEIST IDKVSVLDYL SYAVYQQGDL  60
   61 DKALLLTKKL LELDPEHQRA NGNLKYFEYI MAKEKDVNKS ASDDQSDQKT TPKKKGVAVD 120
  121 YL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1tjcA
Description: Crystal structure of peptide-substrate-binding domain of human type I collagen prolyl 4-hydroxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
procollagen-proline 4-dioxygenase activity 7.0422525853653 bayes_pls_golite062009
procollagen-proline dioxygenase activity 7.0422525853653 bayes_pls_golite062009
peptidyl-proline dioxygenase activity 7.0422525853653 bayes_pls_golite062009
peptidyl-proline 4-dioxygenase activity 7.0422525853653 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 5.01373106146099 bayes_pls_golite062009
binding 2.09193012129784 bayes_pls_golite062009
protein binding 1.52807685989528 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor 0.534990536504941 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [284-369]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PERQKYEMLC RGEGIKMTPR RQKKLFCRYH DGNRNPKFIL APAKQEDEWD KPRIIRFHDI  60
   61 ISDAEIEIVK DLAKPRLRRA TISNPI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1wao1
Description: PP5 structure
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [370-534]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGDLETVHYR ISKSAWLSGY ENPVVSRINM RIQDLTGLDV STAEELQVAN YGVGGQYEPH  60
   61 FDFARKDEPD AFKELGTGNR IATWLFYMSD VSAGGATVFP EVGASVWPKK GTAVFWYNLF 120
  121 ASGEGDYSTR HAACPVLVGN KWVSNKWLHE RGQEFRRPCT LSELE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.63
Match: 2hbtA
Description: No description for 2hbtA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle