YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|62897481, gi\|...
Organism:	Homo sapiens
Length:	534 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|62897481, gi|....

Description	E-value	Query Range	Subject Range
P4HA1_PONPY - Prolyl 4-hydroxylase subunit alpha-1 precursor - Pongo pygmaeus (Orangutan) gi\|123981532, gi... - gi\|123996359\|gb\|ABM85781.1\| procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase... gi\|114631179, gi... - gi\|114631187\|ref\|XP_001141043.1\| PREDICTED: prolyl 4-hydroxylase, alpha I subunit isoform 12 [Pan tr... P4HA1_PONAB - Prolyl 4-hydroxylase subunit alpha-1 OS=Pongo abelii GN=P4HA1 PE=2 SV=1 P4HA1 - prolyl 4-hydroxylase, alpha polypeptide I	0.0	[1..534]	[1..534]
gi\|50749316 - gi\|50749316\|ref\|XP_421583.1\| PREDICTED: similar to Prolyl 4-hydroxylase alpha-1 subunit (4-PH alpha-...	0.0	[2..534]	[6..536]
gi\|73952886 - gi\|73952886\|ref\|XP_850682.1\| PREDICTED: similar to prolyl 4-hydroxylase, alpha I subunit isoform 1 p...	0.0	[1..534]	[1..534]
gi\|109488103 - gi\|109488103\|ref\|XP_340799.3\| PREDICTED: similar to Prolyl 4-hydroxylase alpha-2 subunit precursor (...	0.0	[3..534]	[134..664]
P4HA1_BOVIN - Prolyl 4-hydroxylase subunit alpha-1 OS=Bos taurus GN=P4HA1 PE=1 SV=1	0.0	[1..534]	[1..534]
gi\|109089332 - gi\|109089332\|ref\|XP_001103971.1\| PREDICTED: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proli...	0.0	[1..534]	[1..532]

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Predicted Domain #1

Region A:
Residues: [1-161]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIWYILIIGI LLPQSLAHPG FFTSIGQMTD LIHTEKDLVT SLKDYIKAEE DKLEQIKKWA  60
   61 EKLDRLTSTA TKDPEGFVGH PVNAFKLMKR LNTEWSELEN LVLKDMSDGF ISNLTIQRQY 120
  121 FPNDEDQVGA AKALLRLQDT YNLDTDTISK GNLPGVKHKS F

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	75.075721
Match:	PF08336.2
Description:	No description for PF08336.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [162-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTAEDCFELG KVAYTEADYY HTELWMEQAL RQLDEGEIST IDKVSVLDYL SYAVYQQGDL  60
   61 DKALLLTKKL LELDPEHQRA NGNLKYFEYI MAKEKDVNKS ASDDQSD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.39794
Match:	1tjcA
Description:	Crystal structure of peptide-substrate-binding domain of human type I collagen prolyl 4-hydroxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
procollagen-proline 4-dioxygenase activity	7.0422525853653	bayes_pls_golite062009
procollagen-proline dioxygenase activity	7.0422525853653	bayes_pls_golite062009
peptidyl-proline dioxygenase activity	7.0422525853653	bayes_pls_golite062009
peptidyl-proline 4-dioxygenase activity	7.0422525853653	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	5.01373106146099	bayes_pls_golite062009
binding	2.09193012129784	bayes_pls_golite062009
protein binding	1.52807685989528	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor	0.534990536504941	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [269-423]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKTTPKKKGV AVDYLPERQK YEMLCRGEGI KMTPRRQKKL FCRYHDGNRN PKFILAPAKQ  60
   61 EDEWDKPRII RFHDIISDAE IEIVKDLAKP RLSRATVHDP ETGKLTTAQY RVSKSAWLSG 120
  121 YENPVVSRIN MRIQDLTGLD VSTAEELQVA NYGVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.0
Match:	1wao1
Description:	PP5 structure
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein serine/threonine phosphatase activity	3.14752204226302	bayes_pls_golite062009
phosphoprotein phosphatase activity	2.71668087029212	bayes_pls_golite062009
phosphatase activity	2.37908688123878	bayes_pls_golite062009
phosphoric ester hydrolase activity	2.35252321251549	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.79217430741633	bayes_pls_golite062009
hydrolase activity	1.62124038884947	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
binding	0.817571008545484	bayes_pls_golite062009
protein binding	0.184079020957384	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [424-534]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQYEPHFDFA RKDEPDAFKE LGTGNRIATW LFYMSDVSAG GATVFPEVGA SVWPKKGTAV  60
   61 FWYNLFASGE GDYSTRHAAC PVLVGNKWVS NKWLHERGQE FRRPCTLSEL E

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.62
Match:	2hbtA
Description:	No description for 2hbtA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: