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View Structure Prediction Details

Protein: JMJD5
Organism: Homo sapiens
Length: 416 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for JMJD5.

Description E-value Query
Range
Subject
Range
gi|10435927, gi|... - gi|13376123|ref|NP_079049.1| jumonji domain containing 5 [Homo sapiens], gi|10435927|dbj|BAB14706.1|...
0.0 [1..416] [1..416]
gi|114661702, gi... - gi|114661702|ref|XP_001135546.1| PREDICTED: jumonji domain containing 5 isoform 2 [Pan troglodytes],...
0.0 [1..416] [1..416]
gi|109127990 - gi|109127990|ref|XP_001100489.1| PREDICTED: similar to CG13902-PA [Macaca mulatta]
0.0 [1..416] [1..416]
KDM8_RAT - Lysine-specific demethylase 8 OS=Rattus norvegicus GN=Kdm8 PE=2 SV=1
0.0 [1..416] [1..414]
KDM8_MOUSE - Lysine-specific demethylase 8 OS=Mus musculus GN=Kdm8 PE=2 SV=1
0.0 [1..416] [1..414]
gi|73958640 - gi|73958640|ref|XP_850038.1| PREDICTED: similar to CG13902-PA [Canis familiaris]
0.0 [1..416] [1..414]
KDM8_BOVIN - Lysine-specific demethylase 8 OS=Bos taurus GN=KDM8 PE=2 SV=1
0.0 [12..416] [1..406]
gi|50755749 - gi|50755749|ref|XP_414883.1| PREDICTED: similar to Hypothetical protein FLJ13798 [Gallus gallus]
2.0E-90 [12..416] [1..401]
gi|18402759, gi|... - gi|9294408|dbj|BAB02489.1| unnamed protein product [Arabidopsis thaliana], gi|21536708|gb|AAM61040.1...
2.0E-89 [63..416] [51..410]

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Predicted Domain #1
Region A:
Residues: [1-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGDTHCPAE PLAREGTLWE ALRALLPHSK EDLKLDLGEK VERSVVTLLQ RATELFYEGR  60
   61 RDECLQSSEV ILDYSWEKLN TGTWQDVDKD WRRVYAIGCL LKALCLCQAP EDANTVAAAL 120
  121 RVCDMGLLMG AA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [133-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILGDILLKVA AILQTHLPGK RPARGSLPEQ PCTKKARADH GLIPDVKLEK TVPRLHRPSL  60
   61 QHFREQFLVP GRPVILKGVA DHWPCMQKWS LEYIQEIAGC RTVPVEVGSR YTDEEWSQTL 120
  121 MTVNEFISKY IVNEPRDVGY LAQHQLFDQI PELKQDISIP DYCSLGDGEE EEITINAWFG 180
  181 PQGTISPLHQ DPQQNFLVQV MGRKYIRLYS PQESGALYPH DTHLLHNTSQ VDVENPDLEK 240
  241 FPKFAKAPFL SCILSPGEIL FIPVKYWHYV RALDLSFSVS FWWS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.0
Match: 1iz3A
Description: Hypoxia-inducible factor HIF ihhibitor (FIH1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.154892236593256 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle