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View Structure Prediction Details

Protein: CRP
Organism: Homo sapiens
Length: 224 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CRP.

Description E-value Query
Range
Subject
Range
gi|114560580 - gi|114560580|ref|XP_513917.2| PREDICTED: C-reactive protein, pentraxin-related isoform 3 [Pan troglo...
3.0E-64 [1..224] [1..224]
gi|109017524 - gi|109017524|ref|XP_001117250.1| PREDICTED: C-reactive protein, pentraxin-related isoform 2 [Macaca ...
6.0E-61 [1..223] [1..223]
CRP_RAT - C-reactive protein OS=Rattus norvegicus GN=Crp PE=1 SV=1
3.0E-59 [1..224] [1..223]
gi|30224 - gi|30224|emb|CAA39671.1| C-reactive protein [Homo sapiens]
4.0E-59 [1..224] [1..224]
gi|164902, gi|74... - pir||CJRB C-reactive protein precursor - rabbit, gi|164902|gb|AAA31206.1| C-reactive preprotein, gi...
2.0E-58 [1..224] [1..225]
CRP_MESAU - C-reactive protein OS=Mesocricetus auratus GN=CRP PE=2 SV=1
6.0E-58 [1..224] [1..225]
gi|6681025, gi|1... - ref|NP_031794.1| C-reactive protein, petaxin related [Mus musculus], gi|50564|emb|CAA35531.1| precu...
8.0E-58 [1..223] [1..224]
CRP_PIG - C-reactive protein OS=Sus scrofa GN=CRP PE=2 SV=1
gi|55742770 - ref|NP_999009.1| C-reactive protein [Sus scrofa]
8.0E-58 [1..224] [1..222]

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Predicted Domain #1
Region A:
Residues: [1-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKLLCFLVL TSLSHAFGQT DMSRKAFVFP KESDTSYVSL KAPLTKPLKA FTVCLHFYTE  60
   61 LSSTRGYSIF SYATKRQDNE ILIFWSKDIG YSFTVGGSEI LFEVPEVTVA PVHICTSWES 120
  121 ASGIVEFWVD GKPRVRKSLK KGYTVGAEAS IILGQEQDSF GGNFEGSQSL VGDIGNVNMW 180
  181 DFVLSPDEIN TIYLGGPFSP NVLNWRALKY EVQGEVFTKP QLWP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.09691
Match: 1b09A
Description: C-reactive protein (CRP)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
bacterial cell surface binding 2.42404943659494 bayes_pls_golite062009
monosaccharide binding 2.2299537316674 bayes_pls_golite062009
carbohydrate binding 1.90829797790335 bayes_pls_golite062009
binding 1.49960529341364 bayes_pls_golite062009
sugar binding 1.27754120053722 bayes_pls_golite062009
glycosaminoglycan binding 1.02180056687529 bayes_pls_golite062009
polysaccharide binding 0.85889680769129 bayes_pls_golite062009
pattern binding 0.83687933614214 bayes_pls_golite062009
heparin binding 0.831838523439571 bayes_pls_golite062009
transporter activity 0.768283508128459 bayes_pls_golite062009
receptor binding 0.60563836761885 bayes_pls_golite062009
extracellular matrix structural constituent 0.52360080681204 bayes_pls_golite062009
transmembrane transporter activity 0.508842034055442 bayes_pls_golite062009
protein binding 0.501917973797597 bayes_pls_golite062009
cell surface binding 0.445616177401277 bayes_pls_golite062009
unfolded protein binding 0.434943099544291 bayes_pls_golite062009
substrate-specific transporter activity 0.187717152616782 bayes_pls_golite062009
nucleic acid binding 0.171925518657448 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle