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View Structure Prediction Details

Protein: PAK1
Organism: Homo sapiens
Length: 545 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PAK1.

Description E-value Query
Range
Subject
Range
PAK1 - p21 protein (Cdc42/Rac)-activated kinase 1
gi|254071369 - gi|254071369|gb|ACT64444.1| p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) protein [synthe...
496.0 [0..1] [545..1]
gi|109108025, gi... - gi|109108025|ref|XP_001090310.1| PREDICTED: similar to p21-activated kinase 1 isoform 7 [Macaca mula...
494.0 [0..1] [545..1]
PAK1_BOVIN - Serine/threonine-protein kinase PAK 1 OS=Bos taurus GN=PAK1 PE=1 SV=1
492.0 [0..1] [545..1]
PAK1_RAT - Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3
489.0 [0..1] [545..1]
gi|189442765, gi... - gi|189442765|gb|AAI67167.1| P21 (CDKN1A)-activated kinase 1 [synthetic construct], gi|117616152|gb|A...
gi|112181194, gi... - gi|148684379|gb|EDL16326.1| p21 (CDKN1A)-activated kinase 1, isoform CRA_b [Mus musculus], gi|148684...
489.0 [0..1] [545..1]

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Predicted Domain #1
Region A:
Residues: [1-169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNGLDIQD KPPAPPMRNT STMIGVGSKD AGTLNHGSKP LPPNPEEKKK KDRFYRSILP  60
   61 GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN 120
  121 PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNALN VKAVSETPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1f3mA
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [170-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPPVSEDEDD DDDDATPPPV IAPRPEHTKS VYTRSVIEPL PVTPTRDVAT SPISPTENNT  60
   61 TPPDALTRNT EKQKKKPK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [248-545]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA MDVATGQEVA IKQMNLQQQP  60
   61 KKELIINEIL VMRENKNPNI VNYLDSYLVG DELWVVMEYL AGGSLTDVVT ETCMDEGQIA 120
  121 AVCRECLQAL EFLHSNQVIH RDIKSDNILL GMDGSVKLTD FGFCAQITPE QSKRSTMVGT 180
  181 PYWMAPEVVT RKAYGPKVDI WSLGIMAIEM IEGEPPYLNE NPLRALYLIA TNGTPELQNP 240
  241 EKLSAIFRDF LNRCLDMDVE KRGSAKELLQ HQFLKIAKPL SSLTPLIAAA KEATKNNH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.0
Match: 1f3mC
Description: pak1
Matching Structure (courtesy of the PDB):

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