YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: NOG
Organism: Homo sapiens
Length: 232 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOG.

Description E-value Query
Range
Subject
Range
gi|60810121 - gi|60810121|gb|AAX36116.1| noggin [synthetic construct]
0.0 [1..232] [1..232]
gi|114669450 - gi|114669450|ref|XP_523802.2| PREDICTED: noggin [Pan troglodytes]
0.0 [1..232] [1..232]
NOGG_MOUSE - Noggin OS=Mus musculus GN=Nog PE=2 SV=1
gi|34873295, gi|... - ref|XP_343955.1| similar to noggin [Rattus norvegicus], gi|158187531|ref|NP_037122.1| noggin [Rattu...
0.0 [1..232] [1..232]
gi|109488785 - gi|109488785|ref|XP_343955.3| PREDICTED: similar to Noggin precursor [Rattus norvegicus]
0.0 [1..232] [355..586]
gi|76642650 - gi|76642650|ref|XP_582573.2| PREDICTED: similar to Noggin precursor [Bos taurus]
0.0 [1..232] [230..461]
gi|21105761 - gi|21105761|gb|AAM34779.1|AF510666_1 noggin [Equus caballus]
0.0 [1..227] [1..227]
NOGG_CHICK - Noggin OS=Gallus gallus GN=NOG PE=2 SV=1
0.0 [8..232] [7..223]
gi|60499110 - gi|60499110|gb|AAR03825.2| noggin [Trachemys scripta]
1.0E-99 [8..232] [7..223]

Back

Predicted Domain #1
Region A:
Residues: [1-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD  60
   61 LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI 120
  121 KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS 180
  181 KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.522879
Match: 1m4uA
Description: Noggin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor serine/threonine kinase binding 4.8369569327215 bayes_pls_golite062009
growth factor activity 4.74498867224238 bayes_pls_golite062009
receptor binding 4.70889547404918 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 4.69128752159226 bayes_pls_golite062009
transforming growth factor beta receptor binding 4.69128752159226 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 3.6158922900246 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
protein binding 3.16282476674164 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 3.06631842262117 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 2.88765567751765 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 2.76400237542695 bayes_pls_golite062009
glycosaminoglycan binding 2.49731836866959 bayes_pls_golite062009
growth factor binding 2.41942870726502 bayes_pls_golite062009
binding 2.37954321554411 bayes_pls_golite062009
heparin binding 2.11784489374422 bayes_pls_golite062009
platelet-derived growth factor binding 2.01091405432331 bayes_pls_golite062009
hormone activity 1.83166472515554 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.78479767888975 bayes_pls_golite062009
collagen binding 1.64555624988816 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 1.5411449057785 bayes_pls_golite062009
protein dimerization activity 1.44846386076063 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
protein homodimerization activity 1.13743310822539 bayes_pls_golite062009
identical protein binding 1.0030262164995 bayes_pls_golite062009
morphogen activity 0.91146826241391 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.583797120004309 bayes_pls_golite062009
protein heterodimerization activity 0.408562885230686 bayes_pls_golite062009
signal transducer activity 0.102347067903142 bayes_pls_golite062009
molecular transducer activity 0.102347067903142 bayes_pls_golite062009
fibronectin binding 0.0979012997097199 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle