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View Structure Prediction Details

Protein: gi|85397861, gi|...
Organism: Homo sapiens
Length: 253 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|85397861, gi|....

Description E-value Query
Range
Subject
Range
gi|644788 - gi|644788|gb|AAA86702.1| interleukin-12 beta p35 subunit
0.0 [1..253] [1..253]
gi|113461959, gi... - gi|644802|gb|AAA86707.1| interleukin-12 beta p35 subunit, gi|113461959|ref|NP_001038199.1| interleuk...
0.0 [1..253] [1..253]
gi|162951998, gi... - gi|29569757|gb|AAO85332.1| interleukin-12 beta p35 subunit precursor [Papio anubis], gi|162951998|re...
0.0 [1..253] [1..253]
gi|114590122 - gi|114590122|ref|XP_001156599.1| PREDICTED: interleukin 12A isoform 1 [Pan troglodytes]
0.0 [1..253] [1..250]
gi|927205, gi|47... - gi|927205|gb|AAA73897.1| interleukin 12 p35 subunit [Sus scrofa], gi|47522812|ref|NP_999158.1| inter...
0.0 [20..253] [17..256]
IL12A - interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1,...
0.0 [35..253] [1..219]
gi|18656517 - gi|18656517|gb|AAL77817.1|AF401989_1 single chain interleukin-12 [synthetic construct]
0.0 [57..253] [345..541]
IL12A_LAMGL - Interleukin-12 subunit alpha OS=Lama glama GN=IL12A PE=2 SV=1
0.0 [35..253] [1..222]

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Predicted Domain #1
Region A:
Residues: [1-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWPPGSASQP PPSPAAATGL HPAARPVSLQ CRLSMCPARS LLLVATLVLL DHLSLARNLP  60
   61 VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS EEIDHEDITK DKTSTVEACL 120
  121 PLELTKNESC LNSRETSFIT NGSCLASRKT SFMMALCLSS IYEDLKMYQV EFKTMNAKLL 180
  181 MDPKRQIFLD QNMLAVIDEL MQALNFNSET VPQKSSLEEP DFYKTKIKLC ILLHAFRIRA 240
  241 VTIDRVMSYL NAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 101.0
Match: 1f45B
Description: Heterodimeric interleukin-12 alpha chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
interleukin-12 binding 6.97623072079116 bayes_pls_golite062009
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
interleukin-27 binding 6.42738636095917 bayes_pls_golite062009
interleukin-12 beta subunit binding 5.72528664872472 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 5.22856893358132 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
interleukin-12 receptor binding 4.74969286958651 bayes_pls_golite062009
protein binding 3.26483713001551 bayes_pls_golite062009
binding 2.48265117231403 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
interleukin-6 receptor binding 2.37535614986843 bayes_pls_golite062009
hormone activity 2.25587306265428 bayes_pls_golite062009
growth hormone activity 1.87531277315347 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 1.79326213321183 bayes_pls_golite062009
interleukin-2 receptor binding 1.24568403220915 bayes_pls_golite062009
interleukin-10 receptor binding 1.21666375770079 bayes_pls_golite062009
macrophage colony stimulating factor receptor binding 1.01092937856314 bayes_pls_golite062009
interferon-alpha/beta receptor binding 0.93290045827216 bayes_pls_golite062009
erythropoietin receptor binding 0.77580300541347 bayes_pls_golite062009
transcription regulator activity 0.486790888007408 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle