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View Structure Prediction Details

Protein: APCS
Organism: Homo sapiens
Length: 223 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APCS.

Description E-value Query
Range
Subject
Range
gi|109017517 - gi|109017517|ref|XP_001117234.1| PREDICTED: similar to serum amyloid P component precursor [Macaca m...
2.0E-64 [1..223] [1..223]
CRP_RAT - C-reactive protein OS=Rattus norvegicus GN=Crp PE=1 SV=1
1.0E-62 [1..222] [1..222]
gi|114560576 - gi|114560576|ref|XP_513916.2| PREDICTED: hypothetical protein [Pan troglodytes]
4.0E-62 [1..223] [1..223]
gi|60653495, gi|... - gi|60653497|gb|AAX29442.1| amyloid P component serum [synthetic construct], gi|60653495|gb|AAX29441....
2.0E-61 [1..223] [1..223]
gi|6681025, gi|1... - ref|NP_031794.1| C-reactive protein, petaxin related [Mus musculus], gi|50564|emb|CAA35531.1| precu...
3.0E-61 [1..222] [1..224]
gi|337758 - gi|337758|gb|AAA60302.1| pre-serum amyloid P component [Homo sapiens]
4.0E-61 [1..223] [1..223]
gi|164902, gi|74... - pir||CJRB C-reactive protein precursor - rabbit, gi|164902|gb|AAA31206.1| C-reactive preprotein, gi...
3.0E-60 [1..222] [1..224]

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Predicted Domain #1
Region A:
Residues: [1-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS  60
   61 DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS 120
  121 SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD 180
  181 SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.522879
Match: 1gykA
Description: Serum amyloid P component (SAP)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
bacterial cell surface binding 2.42404943659494 bayes_pls_golite062009
monosaccharide binding 2.2299537316674 bayes_pls_golite062009
carbohydrate binding 1.90829797790335 bayes_pls_golite062009
binding 1.49960529341364 bayes_pls_golite062009
sugar binding 1.27754120053722 bayes_pls_golite062009
glycosaminoglycan binding 1.02180056687529 bayes_pls_golite062009
polysaccharide binding 0.85889680769129 bayes_pls_golite062009
pattern binding 0.83687933614214 bayes_pls_golite062009
heparin binding 0.831838523439571 bayes_pls_golite062009
transporter activity 0.768283508128459 bayes_pls_golite062009
receptor binding 0.60563836761885 bayes_pls_golite062009
extracellular matrix structural constituent 0.52360080681204 bayes_pls_golite062009
transmembrane transporter activity 0.508842034055442 bayes_pls_golite062009
protein binding 0.501917973797597 bayes_pls_golite062009
cell surface binding 0.445616177401277 bayes_pls_golite062009
unfolded protein binding 0.434943099544291 bayes_pls_golite062009
substrate-specific transporter activity 0.187717152616782 bayes_pls_golite062009
nucleic acid binding 0.171925518657448 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle